Matrix Metalloproteinase 26 Proteolysis of the NH2-Terminal Domain of the Estrogen Receptor β Correlates with the Survival of Breast Cancer Patients

Savinov, Alexei Y.; Remacle, Albert G.; Golubkov, Vladislav S.; Krajewska, Maryla; Kennedy, Susan; Duffy, Michael J.; Rozanov, Dmitri V.; Krajewski, Stan; Strongin, Alex Y.

doi:10.1158/0008-5472.can-05-3592

Cited by 54 publications

(54 citation statements)

References 42 publications

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“…A second mechanism, by which MMPs might function as inhibitors of tumour progression, is via their ability to cleave cellsurface receptors. The proteolytic cleavage of the oestrogen receptor b by MMP-26 was recently demonstrated by Savinov et al (2006) and this correlated with longer survival in patients with breast cancer. Finally, increased MMP activity has been shown to disrupt or denature adhesion molecules such as E-cadherin, thereby instigating tumour regression (Simian et al, 2006).…”

Section: Discussionmentioning

confidence: 89%

The collagenase-1 (MMP-1) gene promoter polymorphism - 1607/2G is associated with favourable prognosis in patients with colorectal cancer

et al. 2007

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Matrix metalloproteinase (MMP) overexpression has been implicated in the pathogenesis of colorectal carcinoma (CRC). Accumulating evidence suggests that MMP promoter single nucleotide polymorphisms (SNPs) effecting gene transcription are associated with enhanced susceptibility for the development of malignant disease, increased tumour invasiveness and poor patient survival. The aim of the current investigation was to determine whether such associations exist in a large CRC patient/control study population. Using an allelic discrimination real-time polymerase chain reaction, polymorphisms in the MMP-1, MMP-2 and MMP-3 gene promoters (À1607, À1306, and À1612 bp, respectively) were assessed in normal blood mononuclear cells from patients with CRC (n ¼ 503) and control subjects (n ¼ 471). Genotypes corresponding to each MMP SNP were correlated with tumour characteristics and clinical outcome. The frequency of each genotype was not statistically different between patients and control subjects and no significant differences were noted between the genotypes and tumour characteristics for the three MMP SNPs. CRC patients with the 2G/2G genotype for the MMP-1 SNP had significantly better 5-year survival compared to patients with a 1G allele (Po0.05). Our results demonstrate that CRC patients with a 2G/2G genotype in the MMP-1 gene promoter SNP have a favourable prognosis. Although our results were unexpected, given that this genotype is associated with enhanced MMP-1 transcriptional activity, they are consistent with recent data highlighting the anti-tumorigenic properties of MMPs.

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Section: Discussionmentioning

confidence: 89%

The collagenase-1 (MMP-1) gene promoter polymorphism - 1607/2G is associated with favourable prognosis in patients with colorectal cancer

et al. 2007

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“…23 MMP-26 expression is upregulated in dysplastic changes in prostatic tissue but downregulated in invasive cancer, 24 and in a similar manner it becomes downregulated during histological dedifferentiation of cutaneous SCCs 21 and spreading of ductal breast cancers. 25,26 MMP-26 expression has also been reported in invasive esophageal, ovarian, and endometrial cancers. 18,27,28 MMPs also have natural inhibitors called TIMPs.…”

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confidence: 98%

Increased expression of matrix metalloproteinases-21 and -26 and TIMP-4 in pancreatic adenocarcinoma

et al. 2007

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Pancreatic adenocarcinoma is known for early aggressive local invasion, high metastatic potential, and a low 5-year survival rate. Matrix metalloproteinases (MMPs) play important roles in tumor growth and invasion. Earlier studies on pancreatic cancer have found increased expression of certain MMPs to correlate with poorer prognosis, short survival time or presence of metastases. We studied the expression of MMP-21, -26, and tissue inhibitor of matrix metalloproteinases ( Keywords: matrix metalloproteinase; adenocarcinoma; tissue inhibitor of metalloproteinase Pancreatic cancer is one of the most lethal types of cancer: the 5-year survival rate of pancreatic adenocarcinoma is under 5%.1,2 Other types of pancreatic tumors (15% of all tumors) include insulinoma, gastrinoma, and carcinoid tumor. Pancreatic cancer is notorious for its late clinical presentation, early and aggressive local invasion, and metastatic potential.3 The diagnosis is confirmed using ultrasound combined with biopsy as well as computed tomography, and tumor markers such as CA 19-9. If metastases are not found, the Whipple operation (pancreaticoduodenectomy) is performed to remove the tumor. If metastases are detected, palliative treatments are chosen, such as biliary bypass procedure or chemo/radiotherapy. A known risk factor for pancreatic cancer is smoking, which increases the risk two-to three-fold. 4 Also, patients with chronic pancreatitis have increased risk for developing pancreatic carcinoma. 5,6

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“…The elevated expression of MMP-26 is correlated with myometrial invasion of endometrial carcinoma (17,19). MMP-26 also contributes to the local depth of invasion in breast carcinoma, prostate carci-noma and esophageal squamous cell carcinoma (14,(20)(21)(22)(23)(24)(25)(26). The expression of MMP-26 seems to be located in the invading cells.…”

Section: Introductionmentioning

confidence: 97%

Expression of matrix metalloproteinase-26 promotes human glioma U251 cell invasion in vitro and in vivo

Li¹

2009

Oncol Rep

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Abstract. MMP-26 is a novel member of the MMP family and is widely expressed in cancer cells of epithelial origin. Published research shows that MMP-26 contributes to tumor development and to the restoration of tissue injury. In this study, in order to identify the functions of MMP-26 that contribute to the biological phenotype and behavior of non-epithelial human glioma U251cells, we established an MMP-26 overexpressing tumor cell model using gene transfection. We then used these cells to investigate the role of MMP-26 in tumor progression. Adherence and spreading assay, wound healing assay, Boyden chamber invasion assay, and in vivo tumorigenicity assay were performed to analyze the invasion ability of MMP-26 transfected U251 cells. Microvessel density analysis and tumor cell induced angiogenesis assay were employed to detect the function of MMP-26 in angiogenesis. Results showed that the spreading cell ratio of MMP-26 transfected cells was significantly higher than parental U251 cells. The relative migration distance of MMP-26 transfected cells on Matrigel was significantly higher than that of parental U251 cells. The Boyden chamber assay showed that MMP-26 could significantly enhance the ability of U251 cells to invade through Matrigel. MMP-26 could also enhance the local invasion ability of U251 cells in vivo. There was a significant increase of the microvessel density of tumor tissue derived from MMP-26 transfected U251 cells. The vessel numbe induced by MMP-26 transfected U251 cells in nude mice was also significantly higher than that induced by parental U251 cells. In conclusion, we successfully established an MMP-26 overexpressing cell model and confirmed that MMP-26 contributed to U251 cell invasion and migration in vitro. We also demonstrated that MMP-26 plays an important role in local invasion, and angiogenesis.

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Matrix Metalloproteinase 26 Proteolysis of the NH2-Terminal Domain of the Estrogen Receptor β Correlates with the Survival of Breast Cancer Patients

Cited by 54 publications

References 42 publications

The collagenase-1 (MMP-1) gene promoter polymorphism - 1607/2G is associated with favourable prognosis in patients with colorectal cancer

The collagenase-1 (MMP-1) gene promoter polymorphism - 1607/2G is associated with favourable prognosis in patients with colorectal cancer

Increased expression of matrix metalloproteinases-21 and -26 and TIMP-4 in pancreatic adenocarcinoma

Expression of matrix metalloproteinase-26 promotes human glioma U251 cell invasion in vitro and in vivo

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