Matrix metalloproteinase‐7 triggers the matricrine action of insulin‐like growth factor‐II via proteinase activity on insulin‐like growth factor binding protein 2 in the extracellular matrix

Miyamoto, Shinpei; Nakamura, Michio; Yano, Keiichi; Ishii, Genichiro; Hasebe, Takahiro; Endoh, Yasushi; Sangai, Takafumi; Maeda, Hitoshi; Shi-chuang, Zhang; Chiba, Tsutomu; Ochiai, Atsushi

doi:10.1111/j.1349-7006.2007.00448.x

Cited by 51 publications

(37 citation statements)

References 52 publications

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“…To our knowledge, increased MMP-7 level has not ever been described at post-chemotherapy disease progression, although increased proteolytic degradation of IGFBP-3 has been described in breast cancer patients (Helle et al 2001). Furthermore, recent in vitro data have shown that MMP-7 degrades IGFBP-2 in colorectal cell lines via proteinase activity (Miyamoto et al 2007).…”

Section: Discussionmentioning

confidence: 94%

Serum IGF-I, IGFBP-3, and matrix metalloproteinase-7 levels and acquired chemo-resistance in advanced colorectal cancer

Gallego¹,

Codony-Servat²,

García-Albéniz³

et al. 2009

Endocrine-Related Cancer

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Insulin-like growth factor-I (IGF-I) is thought to have antiapoptotic and mitogenic properties in colorectal cancer, whereas IGF-binding protein-3 (IGFBP-3) seems to exert a pro-apoptotic effect. Additionally, matrix metalloproteinase-7 (MMP-7), an enzyme with in vitro ability to degrade IGFBP-3, has been shown to be a prognostic factor in advanced colorectal cancer (ACRC). We studied whether chemotherapy treatment for ACRC modulates IGF-I, IGFBP-3, and MMP-7 serum levels. In 41 patients undergoing first-line therapy for ACRC, serum levels of IGF-I, IGFBP-3, and MMP-7 were measured with immunoassays at baseline and every 3 months until progressive disease, or a maximum of five determinations, during a chemotherapy regimen of either FOLFOX or FOLFIRI therapies. Associations were assessed for paired samples, using t-test or Wilcoxon ranks test depending on normality of the variable, verified with Shapiro-Wilk test. An average of four extractions (range 3-5) were done, for a total of 157 determinations. Mean pretreatment values of IGF-I, IGFBP-3, and MMP-7 were 83 (95% CI, 73-92) ng/ml, 2372 (95% CI, 2121-2623) ng/ml, and 10.6 (95% CI, 7.21-13.98) ng/ml respectively. No significant changes in IGF-I were found, but a significant increase in IGFBP-3 serum concentrations was observed during or after chemotherapy treatment without progressive disease, compared with basal levels (P!0.001). A significant decrease in IGFBP-3 to 1983 ng/ml (95% CI, 1675-2292) and a significant increase in MMP-7 levels to 14.6 (7.6-21.7) ng/ml were observed at progression of disease compared with baseline and treatment levels (P!0.001). This study shows that IGFBP-3 and MMP-7 serum levels change during chemotherapy treatment. The increased MMP-7 levels at disease progression support the hypothesis that this protease could play a role in acquired resistance by degrading IGFBP-3.

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Section: Discussionmentioning

confidence: 94%

Serum IGF-I, IGFBP-3, and matrix metalloproteinase-7 levels and acquired chemo-resistance in advanced colorectal cancer

Gallego¹,

Codony-Servat²,

García-Albéniz³

et al. 2009

Endocrine-Related Cancer

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“…Generally, cells can receive ECM as a signal that causes changes such as migration, proliferation, and differentiation -a process referred to as 'matricrine' action (Miyamoto et al 2007). In our recent attempt to investigate matricrine action in anterior pituitary cells, FS cells markedly extended their cytoplasmic processes and promoted gap junction formation between them under the influence of laminin that is an ECM component of the basement membrane (Horiguchi et al 2010(Horiguchi et al , 2011.…”

Section: Introductionmentioning

confidence: 99%

Caveolin 3-mediated integrin β1 signaling is required for the proliferation of folliculostellate cells in rat anterior pituitary gland under the influence of extracellular matrix

Horiguchi¹,

Fujiwara²,

Ilmiawati³

et al. 2011

Journal of Endocrinology

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Folliculostellate (FS) cells in the anterior pituitary gland are believed to have multifunctional properties. Using transgenic rats that express green fluorescent protein (GFP) specifically in FS cells in the anterior pituitary gland (S100b-GFP rats), we recently revealed that FS cells in primary culture exhibited marked proliferation in the presence of laminin, an extracellular matrix (ECM) component of the basement membrane. In a process referred to as matricrine action, FS cells receive ECM as a signal through their receptors, which results in morphological and functional changes. In this study, we investigated matricrine signaling in FS cells and observed that the proliferation of FS cells is mediated by integrin b1, which is involved in various signaling pathways for cell migration and proliferation in response to ECM. Then, we analyzed downstream events of the integrin b1 signaling pathway in the proliferation of FS cells and identified caveolin 3 as a potential candidate molecule. Caveolin 3 is a membrane protein that binds cholesterol and a number of signaling molecules that interact with integrin b1. Using specific small interfering RNA of caveolin 3, the proliferation of FS cells was inhibited. Furthermore, caveolin 3 drove activation of the mitogen-activated protein kinase (MAPK) signaling cascades, which resulted in upregulation of cyclin D1 in FS cells. These findings suggest that matricrine signaling in the proliferation of FS cells was transduced by a caveolin 3-mediated integrin b1 signaling pathway and subsequent activation of the MAPK pathway.

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“…FS cells are located in the core of these lobular structures, and, interestingly, the cytoplasmic processes of FS cells attach to the basement membrane (Inoue et al 1999, Shirasawa et al 2004. Generally, FS cells can receive extracellular matrices (ECM) as signals that can exert functional changes, a process called matricrine signaling (Koide & Ito 2000, Miyamoto et al 2007. Based on the histological features of FS cells, we hypothesized that FS cells require matricrine signaling for their functional roles.…”

Section: Introductionmentioning

confidence: 99%

The extracellular matrix component laminin promotes gap junction formation in the rat anterior pituitary gland

Horiguchi¹,

Kouki²,

Fujiwara³

et al. 2010

Journal of Endocrinology

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Folliculo-stellate (FS) cells in the anterior pituitary gland are believed to have multifunctional properties. FS cells connect to each other not only by mechanical means, but also by gap junctional cell-to-cell communication. Using transgenic rats that express green fluorescent protein (GFP) specifically in FS cells in the anterior pituitary gland (S100b-GFP rats), we recently revealed that FS cells in primary culture markedly change their shape, and form numerous interconnections with neighboring FS cells in the presence of laminin, an extracellular matrix (ECM) component of the basement membrane. Morphological and functional changes in cells are believed to be partly modified by matricrine signaling, by which ECM components function as cellular signals. In the present study, we examined whether gap junction formation between FS cells is affected by matricrine cues. A cell sorter was used to isolate FS cells from male S100b-GFP rat anterior pituitary for primary culture. We observed that mRNA and protein levels of connexin 43 in gap junction channels were clearly higher in the presence of laminin. In addition, we confirmed the formation of gap junctions between FS cells in primary culture by electron microscopy. Interestingly, we also observed that FS cells in the presence of laminin displayed well-developed rough endoplasmic reticulum and Golgi apparatus. Our findings suggest that, in anterior pituitary gland, FS cells may facilitate functional roles such as gap junctional cell-to-cell communication by matricrine signaling.

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Matrix metalloproteinase‐7 triggers the matricrine action of insulin‐like growth factor‐II via proteinase activity on insulin‐like growth factor binding protein 2 in the extracellular matrix

Cited by 51 publications

References 52 publications

Serum IGF-I, IGFBP-3, and matrix metalloproteinase-7 levels and acquired chemo-resistance in advanced colorectal cancer

Serum IGF-I, IGFBP-3, and matrix metalloproteinase-7 levels and acquired chemo-resistance in advanced colorectal cancer

Caveolin 3-mediated integrin β1 signaling is required for the proliferation of folliculostellate cells in rat anterior pituitary gland under the influence of extracellular matrix

The extracellular matrix component laminin promotes gap junction formation in the rat anterior pituitary gland

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