Matrix metalloproteinase‐8 levels in periodontal disease patients: A systematic review

Morais, Everton Freitas de; Pinheiro, Juliana Campos; Leite, Rafaella Bastos; Santos, Pedro Paulo Albino dos; Barboza, Carlos Augusto Galvão; Freitas, Roseana A.

doi:10.1111/jre.12495

Cited by 70 publications

(72 citation statements)

References 47 publications

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“…Matrix metalloproteinase‐8 is known to be associated with severe periodontitis. MMP‐8 is secreted by inflammatory cells, such as neutrophils and macrophages, high levels of MMP‐8 concentrations are associated with tissue destruction . MMP‐8 has been stated to have a role in liver fibrosis .…”

Section: Discussionmentioning

confidence: 99%

“…MMP-8 is secreted by inflammatory cells, such as neutrophils and macrophages, high levels of MMP-8 concentrations are associated with tissue destruction. 36 MMP-8 has been stated to have a role in liver fibrosis. 37 Hepatic stellate cells deposit excessive amounts of matrix of collagen type I and II.…”

Section: F I G U R E 3 Clinical and Pathological Findings Of Periodonmentioning

confidence: 99%

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Periodontal disease may induce liver fibrosis in an experimental study on Wistar rats

Meşter

Ciobanu

Taulescu

et al. 2019

Journal of Periodontology

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Background The aim was to assess the effects of periodontal disease in promoting liver fibrosis in a rat model of ligature‐induced periodontitis. Methods Twenty‐four Wistar rats were divided into four groups: control (CTRL), experimental periodontitis group at day 7 (PER7), at day 14 (PER14), at day 21 (PER21). Experimental periodontitis was induced by the placement of a silk ligature around mandibular incisors. The following parameters were assessed: gingival index, tooth mobility; liver status, and portal vein caliber by ultrasound examination; bone retraction, bone mineral density (BMD), bone volume/tissue volume (BV/TV) by micro‐CT analysis; aspartate aminotransferase (ASAT) and alanine aminotransferase (ALAT); oxidative stress (malondialdehyde [MDA], reduced glutathione/oxidative glutathione ratio [GSH/GSSG]), and matrix metalloproteinase‐8 (MMP‐8) levels; and histopathological evaluation of periodontal and liver tissues. Results Periodontal parameters showed the development of periodontitis in experimental groups. Micro‐CT results indicates an increase of bone retraction and BMD values and a decrease of BV/TV value in PER groups. Liver fibrosis could not be diagnosed with ultrasound examination in any of the groups. Elevated levels of ASAT and ALAT in PER groups compared with CTRL group were found. MDA have indicated elevated levels and a decrease of GSH/GSSG ratio in PER group compared with the CTRL group. Levels of MMP‐8 have indicated high values in PER21 compared with the other groups. Histological analysis of the periodontal and liver tissues sustains the link between periodontal and hepatic injury. Conclusion This study demonstrates a positive correlation between periodontal lesions and liver disease. Periodontitis may be an independent risk factor for liver fibrosis.

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Section: Discussionmentioning

confidence: 99%

Section: F I G U R E 3 Clinical and Pathological Findings Of Periodonmentioning

confidence: 99%

Periodontal disease may induce liver fibrosis in an experimental study on Wistar rats

Meşter

Ciobanu

Taulescu

et al. 2019

Journal of Periodontology

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“…36 MMP-8 at higher concentrations was found in individuals with periodontitis compared to those in good health. 37 Abnormalities or overexpression of MMPs in ECM can induce bone resorption or osteolysis. 38 MMP-8 was the pro-active collagenase that can be found in the Western blot results of peri-implantitis patients.…”

Section: Discussionmentioning

confidence: 99%

<p>Exfoliated Human Deciduous Tooth Stem Cells Incorporating Carbonate Apatite Scaffold Enhance BMP-2, BMP-7 and Attenuate MMP-8 Expression During Initial Alveolar Bone Remodeling in Wistar Rats (<em>Rattus norvegicus</em>)</p>

Prahasanti¹,

Nugraha²,

Saskianti³

et al. 2020

CCIDE

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Background: Post-tooth extraction socket preservation is necessary due to alveolar bone resorptive patterns through regenerative dentistry approaches that involve the use of stem cells, scaffold and growth factor. Stem cells derived from human exfoliated deciduous teeth (SHED) are known to potentially possess the osteogenic ability. Meanwhile, carbonate apatite scaffold (CAS) can act as a biocompatible scaffold capable of supporting mesenchymal stem cells (MSCs) to proliferate and differentiate optimally. The aim of this study is to investigate the expression of bone morphogenic protein-2 and 7 (BMP2, BMP7) and Matrix Metalloproteinase-8 (MMP-8) after the transplantation of SHED-incorporated CAS during in vivo bone remodeling. Material and Methods: A total of 14 healthy, male, Wistar rats, whose mandible anterior teeth were extracted by means of sterile needle holder clamps, constituted the subjects of this study of alveolar bone defects. Two research groups were created: a control group (CAS) as group I and an experimental group (CAS + SHED) as group II. SHED with a density of 10 6 cells were incorporated into CAS before being transplanted into the experimental group. After 7 days, all the animals were sacrificed and their mandible anterior region extracted. The BMP2, BMP7 and MMP-8 expression were subsequently analyzed by means of immunostaining. An unpaired t-test was conducted to analyze the treatment and control group (p<0.01) data. Results: The expression of BMP-2 and BMP-7 was higher in group II compared to group I. Meanwhile, the level of MMP-8 was lower in group II than group I. There was greater significant increased expression of BMP-2 and BMP-7 expression in Group II compared to Group I. There was significant decreased expression of MMP-8 between group II than group I (p<0.01). Conclusion: SHED-incorporated CAS can enhance BMP-2 and BMP-7 expression while attenuating MMP-8 expression during in vivo alveolar bone remodeling.

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“…(42) and de Morais et al . (43) for reviews). They work in a protease web to activate each other from their pro‐forms and can work synergistically to breakdown the extracellular matrix.…”

Section: Discussionmentioning

confidence: 99%

Predicted salivary human protease activity in experimental gingivitis revealed by endoProteo‐FASP approach

Mulkern

Hewitt

Parker

et al. 2020

European J Oral Sciences

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Gingivitis is a highly prevalent oral condition that can be studied in humans via the 21‐d experimental gingivitis model, which allows for investigations into the induction and resolution of gingivitis. In this study, we used the autolysis of saliva as a source of peptides to predict the activity of human proteases in saliva during induction and resolution of inflammation. Healthy volunteers, with no remarkable oral or systemic conditions, were recruited into the study and stimulated saliva samples were collected at days 0, 21, and 35 of experimental gingivitis. Plaque and gingival indices were recorded to ensure clinical induction and resolution. Saliva was auto‐digested at 37°C for 18 h before identification of peptides by mass spectrometry. Protease prediction was carried out using Proteasix in silico with the identified peptides. A comparison of day 0 to days 21 and 35 showed changes in predicted protease activity. Correlation network analysis revealed that at day 21 the proteases became less connected and showed a potential for a dysregulated system; by day 35 the connectivity was returning towards similar conditions at day 0. This study demonstrates that changes in predicted proteases are apparent even in saliva collected from donors experiencing inflammation around three teeth.

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Matrix metalloproteinase‐8 levels in periodontal disease patients: A systematic review

Cited by 70 publications

References 47 publications

Periodontal disease may induce liver fibrosis in an experimental study on Wistar rats

Periodontal disease may induce liver fibrosis in an experimental study on Wistar rats

<p>Exfoliated Human Deciduous Tooth Stem Cells Incorporating Carbonate Apatite Scaffold Enhance BMP-2, BMP-7 and Attenuate MMP-8 Expression During Initial Alveolar Bone Remodeling in Wistar Rats (<em>Rattus norvegicus</em>)</p>

Predicted salivary human protease activity in experimental gingivitis revealed by endoProteo‐FASP approach

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