Matrix metalloproteinase-9 in the ventricular cerebrospinal &amp;#64258;uid correlated with the prognosis of traumatic brain injury

Liu, Chun Lin; Chen, Sean Chun-Chang; Lee, Han Chung; Cho, Der Yang

doi:10.5137/1019-5149.jtn.8551-13.0

Cited by 13 publications

(16 citation statements)

References 29 publications

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“…MMP-9 is expressed in normal adult brain and is also elevated in response to TBI (Hadass et al, 2013;Hayashi et al, 2009). In humans, TBI is also associated with rapid increase of increased MMP-9 in brain parenchyma (Guilfoyle et al, 2015), cerebrospinal fluid (Liu, Chen, Lee, & Cho, 2014), and plasma (Copin et al, 2012) and, which may be used for the prognosis of severity and outcome of injury (DeFazio et al, 2014;Vilalta et al, 2008).…”

Section: A Tr I X M E Ta Ll Op Rote I Na S E S ( Mm P S)mentioning

confidence: 99%

Extracellular matrix and traumatic brain injury

George

Geller

2018

J of Neuroscience Research

102

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The Brain Extracellular Matrix (ECM) plays a crucial role in both the developing and adult brain by providing structural support and mediating cell-cell interactions. In this review, we focus on the major constituents of the ECM and how they function in both normal and injured brain, and summarize the changes in the composition of the ECM as well as how these changes either promote or inhibit recovery of function following Traumatic Brain Injury (TBI). Modulation of ECM composition to facilitates neuronal survival, regeneration and axonal outgrowth is a potential therapeutic target for TBI treatment.

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Section: A Tr I X M E Ta Ll Op Rote I Na S E S ( Mm P S)mentioning

confidence: 99%

Extracellular matrix and traumatic brain injury

George

Geller

2018

J of Neuroscience Research

102

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“…Several studies have found that MMPs and VEGF were increased in the blood and cerebrospinal fluid (CSF) of patients with traumatic brain injury (TBI), but were significantly decreased over time. [25][26][27] Our patients were seen > 21 days after injury; therefore, the impact of elevations in MMPs/VEGF occurring in TBI patients on the research is limited. Several studies have reported that the concentration of VEGF was higher in hematoma fluid than in serum in CSDH patients.…”

Section: Mmp-2 Mmp-9 and Vegf In The Development Of Csdhmentioning

confidence: 99%

Role of Matrix Metalloproteinase-2, Matrix Metalloproteinase-9, and Vascular Endothelial Growth Factor in the Development of Chronic Subdural Hematoma

Cong

Zhang

Feng

et al. 2016

Journal of Neurotrauma

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Chronic subdural hematoma (CSDH) is an inflammatory and angiogenic disease. Vascular endothelial growth factor (VEGF) has an important effect on the pathological progression of CSDH. The matrix metalloproteinases (MMPs) and VEGF also play a significant role in pathological angiogenesis. Our research was to investigate the level of MMPs and VEGF in serum and hematoma fluid. Magnetic Resonance Imaging (MRI) shows the characteristics of different stages of CSDH. We also analyzed the relationship between the level of VEGF in subdural hematoma fluid and the appearances of the patients' MRI. We performed a study comparing serum and hematoma fluid in 37 consecutive patients with primary CSDHs using enzyme-linked immunosorbent assay (ELISA). MMP-2 and MMP-9 activity was assayed by the gelatin zymography method. The patients were divided into five groups according to the appearance of the hematomas on MRI: group 1 (T1-weighted low, T2-weighted low, n=4), group 2 (T1-weighted high, T2-weighted low, n=11), group 3 (T1-weighted mixed, T2-weighted mixed, n=9), group 4 (T1-weighted high, T2-weighted high, n=5), and group 5 (T1-weighted low, T2-weighted high, n=8). Neurological status was assessed by Markwalder score on admission and at follow-up. The mean age, sex, and Markwalder score were not significantly different among groups. The mean concentration of VEGF, MMP-2, and MMP-9 were significantly higher in hematoma fluid than in serum (p<0.01). The level of pro-MMP-2 was higher in hematoma fluid (p<0.01). Measurement of MMP-9 showed both pro and active forms in both groups, but levels were higher in hematoma fluid (p<0.01 and p<0.01, respectively). Mean VEGF concentration was highest in group 1 (21,979.3±1387.3 pg/mL), followed by group 2 (20,060.1±1677.2 pg/mL), group 3 (13,746.5±3529.7 pg/mL), group 4 (7523.2±764.9 pg/mL), and lowest in group 5 (6801.9±618.7 pg/mL). There was a significant correlation between VEGF concentrations and MRI type (r=0.854). The present investigation is the first report showing that the concentrations of MMP-2 and MMP-9 are significantly elevated in hematoma fluid, suggesting that the MMPs/VEGF system may be involved in the angiogenesis of CSDH. We also demonstrate a significant correlation between the concentrations of VEGF and MRI appearance. This finding supports the hypothesis that high VEGF concentration in the hematoma fluid is of major pathophysiological importance in the generation and steady increase of the hematoma volume, as well as the determination of MRI appearance.

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“…MMP9 is released from astrocytes, neurons and microglia as well as leukocytes and macrophages as an inactive proprotein, which is then activated by extracellular proteinases. MMP9 has been shown to be a potential biomarker for outcome prediction after neuron damage [ 14 ], and is particularly induced in neuronal lesions and cerebral ischemia [ 16 ]. Moreover, MMP9 might be important in remyelination processes as it facilitates oligodendrocyte regrowth [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

GDF15/MIC1 and MMP9 Cerebrospinal Fluid Levels in Parkinson’s Disease and Lewy Body Dementia

et al. 2016

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Based on animal and ex-vivo experiments, Growth/Differentiation Factor-15 (GDF15, also called Macrophage Inhibitory Cytokine-1, MIC1), a member of the transforming growth factor-beta family, and Matrix Metalloproteinase-9 (MMP9), a member of the matrix metalloprotease family may be potential markers for Lewy body disorders, i.e. Parkinson’s disease with (PDD) and without dementia (PDND) and Lewy body dementia (DLB). GDF15 has a prominent role in development, cell proliferation, differentiation, and repair, whereas MMP9 degrades, as a proteolytic enzyme, components of the extracellular matrix. In this study, cerebrospinal fluid GDF15 and MMP9 levels of 59 PDND, 17 PDD and 23 DLB patients, as well as of 95 controls were determined, and associated with demographic, clinical and biochemical parameters. Our analysis confirmed the already described association of GDF15 levels with age and gender. Corrected GDF15 levels were significantly higher in PDD than in PDND patients, and intermediate in DLB patients. Within Lewy body disorders, GDF15 levels correlated positively with age at onset of Parkinsonism and dementia, Hoehn & Yahr stage and cerebrospinal fluid t-Tau and p-Tau levels, and negatively with the Mini Mental State Examination. Remarkably, it does not relevantly correlate with disease duration. MMP9 was not relevantly associated with any of these parameters. Cerebrospinal GDF15, but not MMP9, may be a potential marker of and in Lewy body disorders.

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Matrix metalloproteinase-9 in the ventricular cerebrospinal ﬂuid correlated with the prognosis of traumatic brain injury

Cited by 13 publications

References 29 publications

Extracellular matrix and traumatic brain injury

Extracellular matrix and traumatic brain injury

Role of Matrix Metalloproteinase-2, Matrix Metalloproteinase-9, and Vascular Endothelial Growth Factor in the Development of Chronic Subdural Hematoma

GDF15/MIC1 and MMP9 Cerebrospinal Fluid Levels in Parkinson’s Disease and Lewy Body Dementia

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