2022
DOI: 10.3390/pathogens11101184
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Matrix Metalloproteinase 9 (MMP-9) and Interleukin-8 (IL-8) in Gingival Crevicular Fluid after Regenerative Therapy in Periodontal Intrabony Defects with and without Systemic Antibiotics—Randomized Clinical Trial

Abstract: The aim of our study was to assess changes in the levels of IL-8 and MMP-9 in gingival crevicular fluid (GCF) collected from the periodontal pocket before and after regenerative surgery with deproteinized bovine bone mineral (DBBM) and collagen membrane (GTR) either independently (DBBM/GTR) or with the postoperative administration of antibiotic (DBBM/GTR+AB). The study involved 41 patients, each with one intrabony defect. IL-8 and MMP-9 were determined before therapy and after 2 weeks, 4 weeks and 6 months fol… Show more

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Cited by 5 publications
(2 citation statements)
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“…Comparison of these present data with the existing literature is challenging. Indeed, most of the authors have analyzed the effect of periodontal therapy on the initial variation of interleukins and MMPs, confirming a significant decrease for IL-1β, IL-6, and MMP-8/9 [ 23 , 45 ]. To the best of our knowledge, this is the first study in which the GCF markers were hypothesized as independent variables at the baseline, influencing the long-term clinical results of periodontal regeneration therapy.…”
Section: Discussionmentioning
confidence: 99%
“…Comparison of these present data with the existing literature is challenging. Indeed, most of the authors have analyzed the effect of periodontal therapy on the initial variation of interleukins and MMPs, confirming a significant decrease for IL-1β, IL-6, and MMP-8/9 [ 23 , 45 ]. To the best of our knowledge, this is the first study in which the GCF markers were hypothesized as independent variables at the baseline, influencing the long-term clinical results of periodontal regeneration therapy.…”
Section: Discussionmentioning
confidence: 99%
“…MMP-9 is secreted as an inactive 92-kDa proenzyme and is activated to 83-kDa mature enzyme [ [178] , [194] , [260] , [261] , [262] ]. The pro-MMP-9 is comprised of four domains such as a signal peptide, the amino-terminal propeptide, the zinc-binding catalytic domain with three fibronectin type II repeats, and the carboxy-terminal hemopexin domain [ [255] , [258] , [263] , 264 , 188 ]. The activation of MMP-9 is mediated through the action of serine proteases, plasmin, or other MMPs such as MMP-3, plasminogen/MMP-3 complex, a complex of pro-MMP-9 and TIMP-1 by the removal of the prodomain and after activation it becomes involved in different physiological processes including the degradation of ECM proteins [ 178 , 179 ].…”
Section: The Role Of Mmps In Osteoarthritismentioning
confidence: 99%