Matrix metalloproteinase-9 (MMP-9) in human intractable epilepsy caused by focal cortical dysplasia

Konopka, Anna; Grajkowska, Wiesława; Ziemiańska, Klaudia; Roszkowski, Marcin; Daszkiewicz, Paweł; Rysz, Andrzej; Marchel, Andrzej; Koperski, Łukasz; Wilczyński, Grzegorz M.; Dzwonek, Joanna

doi:10.1016/j.eplepsyres.2012.09.018

Cited by 59 publications

(59 citation statements)

References 70 publications

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“…Accordingly, changes in the expression of gap junctions [167], glial glutamate transporters [168], water channels (aquaporin-4; [169]), and matrix metalloproteinases (MMP-9 [170]) have been reported in FCD. Recently, changes in extracellular matrix composition with associated altered extracellular space diffusion properties have been detected in both FCD I and II [171].…”

Section: Epileptogenesismentioning

confidence: 99%

Epilepsy Related to Developmental Tumors and Malformations of Cortical Development

Aronica

Crino

2014

Neurotherapeutics

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Section: Epileptogenesismentioning

confidence: 99%

Epilepsy Related to Developmental Tumors and Malformations of Cortical Development

Aronica

Crino

2014

Neurotherapeutics

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“…Prolonged seizures are also related to high serum MMP-9 levels in patients (Suenaga et al, 2008). MMP-9 is also upregulated in the cortex in patients with focal cortical dysplasia, a disorder associated with intractable cortical epilepsy (Konopka et al, 2013). Notably, the prominent upregulation of MMP-9 was observed mainly at postsynaptic sites (i.e., at dendritic spines).…”

Section: Mmp-9 In Aberrant Structural Plasticitymentioning

confidence: 99%

Matrix metalloproteinase-9 involvement in the structural plasticity of dendritic spines

2014

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Dendritic spines are the locus for excitatory synaptic transmission in the brain and thus play a major role in neuronal plasticity. The ability to alter synaptic connections includes volumetric changes in dendritic spines that are driven by scaffolds created by the extracellular matrix (ECM). Here, we review the effects of the proteolytic activity of ECM proteases in physiological and pathological structural plasticity. We use matrix metalloproteinase-9 (MMP-9) as an example of an ECM modifier that has recently emerged as a key molecule in regulating the morphology and dysmorphology of dendritic spines that underlie synaptic plasticity and neurological disorders, respectively. We summarize the influence of MMP-9 on the dynamic remodeling of the ECM via the cleavage of extracellular substrates. We discuss its role in the formation, modification, and maintenance of dendritic spines in learning and memory. Finally, we review research that implicates MMP-9 in aberrant synaptic plasticity and spine dysmorphology in neurological disorders, with a focus on morphological abnormalities of dendritic protrusions that are associated with epilepsy.

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“…Other studies show that MMP-9 is involved in structural remodeling, mossy fiber sprouting, diminished seizure-induced pruning of dendritic spines, and decreased aberrant synaptogenesis. 197,199,203 MMP-2 function in the epileptic brain is less understood than that of MMP-9. Jourquin et al 75 demonstrated that MMP-2 does not contribute to neuronal cell death in epilepsy.…”

Section: Epilepsymentioning

confidence: 99%

Matrix metalloproteinases in the brain and blood–brain barrier: Versatile breakers and makers

Rempe

Hartz

Bauer

2016

J Cereb Blood Flow Metab

520

422

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Matrix metalloproteinases are versatile endopeptidases with many different functions in the body in health and disease. In the brain, matrix metalloproteinases are critical for tissue formation, neuronal network remodeling, and blood-brain barrier integrity. Many reviews have been published on matrix metalloproteinases before, most of which focus on the two best studied matrix metalloproteinases, the gelatinases MMP-2 and MMP-9, and their role in one or two diseases. In this review, we provide a broad overview of the role various matrix metalloproteinases play in brain disorders. We summarize and review current knowledge and understanding of matrix metalloproteinases in the brain and at the bloodbrain barrier in neuroinflammation, multiple sclerosis, cerebral aneurysms, stroke, epilepsy, Alzheimer's disease, Parkinson's disease, and brain cancer. We discuss the detrimental effects matrix metalloproteinases can have in these conditions, contributing to blood-brain barrier leakage, neuroinflammation, neurotoxicity, demyelination, tumor angiogenesis, and cancer metastasis. We also discuss the beneficial role matrix metalloproteinases can play in neuroprotection and anti-inflammation. Finally, we address matrix metalloproteinases as potential therapeutic targets. Together, in this comprehensive review, we summarize current understanding and knowledge of matrix metalloproteinases in the brain and at the blood-brain barrier in brain disorders.

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Matrix metalloproteinase-9 (MMP-9) in human intractable epilepsy caused by focal cortical dysplasia

Cited by 59 publications

References 70 publications

Epilepsy Related to Developmental Tumors and Malformations of Cortical Development

Epilepsy Related to Developmental Tumors and Malformations of Cortical Development

Matrix metalloproteinase-9 involvement in the structural plasticity of dendritic spines

Matrix metalloproteinases in the brain and blood–brain barrier: Versatile breakers and makers

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