Matrix metalloproteinase 9 (MMP9) level and MMP9 -1562C&gt;T in patients with obstructive sleep apnea: a systematic review and meta-analysis of case-control studies

Fang, Xiaolian; Chen, Jun; Wang, Wei; Feng, Guoshuang; Li, Xiaodan; Zhang, Xin; Zhang, Yamei; Zhang, Jie; Xu, Zhifang; Tai, Jun; Ni, Xin

doi:10.1016/j.sleep.2019.11.1247

Cited by 13 publications

(18 citation statements)

References 35 publications

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“…One was performed in the paediatric population [ 33 ] and two others in adults [ 34 , 35 ]. The roles of MMPs in the inflammatory process associated with OSA were reviewed recently by two papers [ 36 , 37 ]. They have been associated with both oxidative stress and cardiovascular diseases by contributing to ischemia/reperfusion injury [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Elevation of CD40/CD40L Inflammatory Pathway Molecules in Carotid Plaques from Moderate-and-Severe Obstructive Sleep Apnea Patients

et al. 2021

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A chronic inflammatory process characteristic of obstructive sleep apnea promotes vascular endothelial dysfunction and atherogenesis. This process can lead to destabilization and rupture of cardiovascular plaques, which clinically manifests as an acute coronary syndrome or stroke. The aim of this study was to investigate the inflammatory pathway leading to plaque destabilization in non-to-mild and moderate-to-severe groups of OSA patients. This prospective study involved enrollment of patients scheduled for endarterectomy. A sleep study was performed prior to surgery. Immunohistochemistry was performed on atherosclerotic plaques from carotid arteries obtained during standard open endarterectomy to determine levels of CD40, CD40L receptors, MCP-1, and MMP-9. The 46 patients included 14 controls, 13 with mild, 11 with moderate, and 8 with severe OSA. Increased expression of CD40, CD40L receptors, MCP-1, and MMP-9 were found to be proportionate with OSA severity. However, significant differences among groups were observed only for MCP-1 (p = 0.014). Increased expression of inflammatory markers (CD40, CD40L, MCP-1, MMP-9) is associated with increasing OSA severity. This suggests the CD40-CD4-L inflammatory pathway may contribute to plaque instability and rupture in OSA patients.

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Section: Discussionmentioning

confidence: 99%

Elevation of CD40/CD40L Inflammatory Pathway Molecules in Carotid Plaques from Moderate-and-Severe Obstructive Sleep Apnea Patients

et al. 2021

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“…shown that the peripheral level of MMP-9 was increased in OSA participants, and the increase was relevant to OSA severity [2,5]. However, any of the previous studies on MMP-9 in OSA did not control for WBC count.…”

Section: Discussionmentioning

confidence: 93%

Serum matrix metalloproteinase-9 activity in obstructive sleep apnea

Franczak¹,

Skomro²,

Bil‐Lula³

et al. 2021

Polish Archives of Internal Medicine

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This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (CC BY-NC-SA 4.0), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited, distributed under the same license, and used for noncommercial purposes only.

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“…Patients with KC have higher MMP-9 in their tear component and serum [ 112 , 113 ]. Similarly, serum concentration of MMP-9 is elevated in patients with OSA and is related to OSA severity, inflammation, and/or severity of hypoxemia [ 26 , 114 ].…”

Section: Osa-associated Complications In Anterior Segment Of Eyementioning

confidence: 99%

“…One theory points to a direct mechanical trauma, prone posture during sleep, with palpebral and conjunctiva rubbing to the pillow resulting in super-expression of elastolytic enzymes and elastin degradation [90]. The other theory proposes activation of cytokines (TNF-α, MMP enzymes) from systemic inflammation and intermittent hypoxia related to OSA, leading to elastin breakdown [18,26,91].…”

Section: Osa and Floppy Eyelid Syndrome (Fes)mentioning

confidence: 99%

“…Previous studies have shown that OSA is associated with increased risks of several vision-threatening and nonthreatening ocular disorders, including senile cataract, normal tension glaucoma, retinal ischemia, conjunctival hyperemia, and dry eye [ 23 ]. Several contributory mechanisms to the ocular complications of OSA have been reported, including intermittent hypoxia, oxidative stress, systemic inflammatory responses (such as interleukin-6 (IL-6), IL-8,tumor necrosis factor-alpha (TNF-α), C-Reactive protein (CRP), matrix metalloproteinase 9 (MMP-9), vascular cell adhesion molecule (VCAM), intercellular adhesion molecule (ICAM), selectins), sympathetic system overaction, damage effects of endothelin-1, and disruption of the blood–retinal barrier (BRB) ( Table 1 ) [ 11 , 12 , 13 , 14 , 15 , 16 , 18 , 19 , 24 , 25 , 26 ]. In addition, OSA-mediated chronic upregulation of systemic inflammation may provoke both ocular and non-ocular complications, such as psoriasis and rheumatoid arthritis, which may cause further ocular abnormalities [ 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

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Ocular Complications of Obstructive Sleep Apnea

Liu

Chiu

Wang

et al. 2021

JCM

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Obstructive sleep apnea (OSA), the most common form of sleep-disordered breathing, is characterized by repetitive episodes of paused breathing during sleep, which in turn induces transient nocturnal hypoxia and hypercapnia. The high prevalence of OSA and its associated health consequences place a heavy burden on the healthcare system. In particular, the consequent episodic oxygenic desaturation/reoxygenation series and arousals from sleep in patients with OSA have the potential to trigger oxidative stress, elevated systemic inflammatory responses, and autonomic dysfunction with sympathetic activation. Given these adverse side-effects, OSA is highly correlated to many eye diseases that are common in everyday ophthalmic practices. Some of these ocular consequences are reversible, but they may permanently threaten a patient’s vision if not treated appropriately. Here, this article seeks to review the ocular consequences and potential pathophysiologic associations in patients with OSA. Understanding these OSA-related eye diseases may help clinicians provide comprehensive care to their patients.

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Matrix metalloproteinase 9 (MMP9) level and MMP9 -1562C>T in patients with obstructive sleep apnea: a systematic review and meta-analysis of case-control studies

Cited by 13 publications

References 35 publications

Elevation of CD40/CD40L Inflammatory Pathway Molecules in Carotid Plaques from Moderate-and-Severe Obstructive Sleep Apnea Patients

Elevation of CD40/CD40L Inflammatory Pathway Molecules in Carotid Plaques from Moderate-and-Severe Obstructive Sleep Apnea Patients

Serum matrix metalloproteinase-9 activity in obstructive sleep apnea

Ocular Complications of Obstructive Sleep Apnea

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