Matrix metalloproteinase inhibition impairs murine adipose tissue development independently of leptin

Hul, Matthias Van; Lijnen, H.R.

doi:10.1507/endocrj.k10e-267

Cited by 29 publications

(22 citation statements)

References 20 publications

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“…Similarly, treatment of obese mice with galardin, a synthetic MMP inhibitor, leads to significant reductions in fat mass (Lijnen et al, 2002). Moreover, both synthetic and endogenous MMP inhibitors inhibit angiogenic responses (Stetler-Stevenson, 1999;Van Hul and Lijnen, 2011). MMPs are essential regulators of various phases of the angiogenic process, indicating the synergistic actions of angiogenesis and MMPs on the regulation of adipose tissue growth.…”

Section: Discussionmentioning

confidence: 99%

Effects of Korean red ginseng (Panax ginseng) on obesity and adipose inflammation in ovariectomized mice

Lee

Choi

Shin

et al. 2016

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

Effects of Korean red ginseng (Panax ginseng) on obesity and adipose inflammation in ovariectomized mice

Lee

Choi

Shin

et al. 2016

Journal of Ethnopharmacology

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“…In [19, 20] Quantitative MMP zymography was performed using previously described procedure. Ten % polyacrylamide gel was prepared containing mg/mL gelatin (Fisher Scientific, Pittsburg, PA).…”

Section: Methodsmentioning

confidence: 99%

Time-Dependent Alterations in Rat Macrovessels with Type 1 Diabetes

Searls

Smirnova

VanHoose

et al. 2012

Experimental Diabetes Research

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Vascular complications are associated with the progressive severity of diabetes, resulting in significant morbidity and mortality. This study quantifies functional vascular parameters and macrovascular structure in a rat model of type 1 diabetes. While there was no difference in the systemic arterial elastance (Ea) with 50 days of diabetes, changes were noted in the aorta and femoral artery including increased tunica media extracellular matrix content, decreased width of both the media and individual smooth muscle cell layers, and increased incidence of damaged mitochondria. Extracellular matrix proteins and elastin levels were significantly greater in the aorta of diabetic animals. These differences correlated with diminished matrix metalloprotease activity in the aorta of the diabetic animals. In conclusion, diabetes significantly altered the structure and ultrastructure of the aorta and femoral artery before systemic changes in arterial elastance could be detected.

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“…As MMP9 is highly expressed by adipose tissue macrophages [49], a further study should be needed to fully define the impact of genetic deletion of MMP9 on adipose inflammation and metabolism. Interestingly, a pharmacological inhibition of MMPs with a relative specificity to MMP2 and MMP9 reduces weight gain and fat pad weights in ob / ob mice [50]. …”

Section: Ecm Modifiers In the Adipose Tissuementioning

confidence: 99%

Adipose extracellular matrix remodelling in obesity and insulin resistance

Lin

Chun

2016

Biochemical Pharmacology

178

130

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The extracellular matrix (ECM) of adipose tissues undergoes constant remodelling to allow adipocytes and their precursor cells to change cell shape and function in adaptation to nutritional cues. Abnormal accumulation of ECM components and their modifiers in adipose tissues has been recently demonstrated to cause obesity-associated insulin resistance, a hallmark of type 2 diabetes. Integrins and other ECM receptors (e.g. CD44) that are expressed in adipose tissues have been shown to regulate insulin sensitivity. It is well understood that a hypoxic response is observed in adipose tissue expansion during obesity progression and that hypoxic response accelerates fibrosis and inflammation in white adipose tissues. The expansion of adipose tissues should require angiogenesis; however, the excess deposition of ECM limits the angiogenic response of white adipose tissues in obesity. While recent studies have focused on the metabolic consequences and the mechanisms of adipose tissue expansion and remodelling, little attention has been paid to the role played by the interaction between peri-adipocyte ECM and their cognate cell surface receptors. This review will address what is currently known about the roles played by adipose ECM, their modifiers, and ECM receptors in obesity and insulin resistance. Understanding how excess ECM deposition in the adipose tissue deteriorates insulin sensitivity would provide us hints to develop a new therapeutic strategy for the treatment of insulin resistance and type 2 diabetes.

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Matrix metalloproteinase inhibition impairs murine adipose tissue development independently of leptin

Cited by 29 publications

References 20 publications

Effects of Korean red ginseng (Panax ginseng) on obesity and adipose inflammation in ovariectomized mice

Effects of Korean red ginseng (Panax ginseng) on obesity and adipose inflammation in ovariectomized mice

Time-Dependent Alterations in Rat Macrovessels with Type 1 Diabetes

Adipose extracellular matrix remodelling in obesity and insulin resistance

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