Matrix metalloproteinase, tissue inhibitor of metalloproteinase and transforming growth factor-beta 1 in frozen shoulder, and their changes as response to intensive stretching and supervised neglect exercise

Lubis, Andri Maruli Tua; Lubis, Vita Kurniati

doi:10.1007/s00776-013-0387-0

Cited by 69 publications

(58 citation statements)

References 25 publications

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“…Kirwan et al (30) reported that cyclical stretch induced MMP-2 expression in human lamina cribrosa cells. Mechanically stretched trabecular meshwork cells have reported increases in MMP-2 protein and gene expression (29,41), increased MMP-14 protein levels (29), and either no change or a decrease in TIMP-2 (29,42). In these cultured cells, mechanical stretch shifted the MMP-TIMP balance and these results suggest mechanical stretch may be involved in the pathogenesis of these diseases (29,30).…”

Section: Discussionmentioning

confidence: 67%

Induction of MMP-1 and −3 by cyclical mechanical stretch is mediated by IL-6 in cultured fibroblasts of keratoconus

Du¹,

Chen²,

Li³

et al. 2017

Molecular Medicine Reports

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Abstract. In order to understand the effect of mechanical stretch on corneal extracellular matrix remodeling, human keratoconus fibroblasts (HKCFBs) were subjected to cyclic stretch in vitro and the expression of matrix metalloproteinases (MMPs), tissue inhibitor of metalloproteinases (TIMPs), and inflammatory cytokines were evaluated. HKCFBs were seeded into a flexible membrane base and subjected to a cyclic stretch regimen of 10% equibiaxial stretch at a stretching frequency of 1 Hz for 6 h using a Flexcell tension unit. An antibody directed against interleukin-6 (IL-6 Ab) was used to investigate the roles of IL-6 on mechanical stretch mediated regulation of MMP in HKCFBs. Culture supernatants were assayed using an enzyme-linked immunosorbent assay for MMP-1 and -3, TIMP-1 and -2, and IL-6. Total RNA from the cells was extracted, and quantitative polymerase chain reaction was used to determine mRNA for MMP-1 and -3, TIMP-1 and -2, and IL-6. In stretched cells, levels of MMP-1 and -3 demonstrated an increase compared with unstretched cells, but levels of TIMP-1, and -2 revealed a decrease. Mechanical stretch significantly increased the mRNA expression and protein synthesis of IL-6 compared with unstretched cells. IL-6 induced MMP-1 and -3 expression, whereas no significant effects were observed in levels of TIMP-1 and -2 compared with the untreated control groups. Additionally, the IL-6 Ab markedly inhibited the stretch-induced increase in MMP-1 and -3 in culture supernatants in a dose-dependent manner. No significant differences in TIMP-1 and -2 protein levels were detected between stretched cells treated with IL-6 Ab and stretched cells without IL-6 Ab treatment. These results indicate that cyclical mechanical stretch augments IL-6 production and MMP expression, and reduces levels of TIMP in HKCFBs. Thus, it is suggested that IL-6 mediates the stretch-induced MMP expression.

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Section: Discussionmentioning

confidence: 67%

Induction of MMP-1 and −3 by cyclical mechanical stretch is mediated by IL-6 in cultured fibroblasts of keratoconus

Du¹,

Chen²,

Li³

et al. 2017

Molecular Medicine Reports

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“…Two studies saw no association with this category of potential biomarkers (49,51). Three studies found increased TIMP (most consistently, TIMP-1) in serum from subjects with adhesive capsulitis, and in serum or palmar fascia from subjects with Dupuytren's contracture (49,50,56). Two of these showed a decreased MMP/TIMP ratio in serum of subjects with fibroproliferative MSD (49,56).…”

Section: Continuedmentioning

confidence: 99%

“…A study of adhesive capsulitis found reduced MMP in patients (56). Two studies saw no association with this category of potential biomarkers (49,51).…”

Section: Continuedmentioning

confidence: 99%

“…Three reported extremely wideranging MSD durations (49, 50, 66) (66: 7-120 months; 49: 7-360 months; 50: 9-288 months). Five studied patients with an average symptom duration of <1 year (33,40,41,54,56).…”

Section: Secondary Screen-quality Assessment Overviewmentioning

confidence: 99%

“…Many studies were conducted in older populations with at least one analysis group >50 years of age (33)(34)(35)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59)(60). The range of symptom duration varied substantially within and across studies.…”

Section: Secondary Screen-quality Assessment Overviewmentioning

confidence: 99%

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Systematic review of biochemical biomarkers for neck and upper-extremity musculoskeletal disorders

Gold¹,

Hallman²,

Hellström³

et al. 2015

Scand J Work Environ Health

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A statistically significant association between the musculoskeletal disorders (MSD) and biomarkers studied was demonstrated in 82% of sufficient quality articles. Evidence suggested that: collagen repair marker (TIMP-1) is decreased in fibroproliferative disorders; serotonin (5-HT) is increased in trapezius myalgia; triglycerides are increased in various MSD. Limitations in the articles include possible selection bias, confounding, spectrum effect, and insufficient attention to comorbid conditions.

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Rat models of frozen shoulder: Classification and evaluation

Gu,

Xie,

et al. 2024

Anim Models and Exp Med

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Frozen shoulder (FS), also known as adhesive capsulitis, is a condition that causes contraction and stiffness of the shoulder joint capsule. The main symptoms are persistent shoulder pain and a limited range of motion in all directions. These symptoms and poor prognosis affect people's physical health and quality of life. Currently, the specific mechanisms of FS remain unclear, and there is variability in treatment methods and their efficacy. Additionally, the early symptoms of FS are difficult to distinguish from those of other shoulder diseases, complicating early diagnosis and treatment. Therefore, it is necessary to develop and utilize animal models to understand the pathogenesis of FS and to explore treatment strategies, providing insights into the prevention and treatment of human FS. This paper reviews the rat models available for FS research, including external immobilization models, surgical internal immobilization models, injection modeling models, and endocrine modeling models. It introduces the basic procedures for these models and compares and analyzes the advantages, disadvantages, and applicability of each modeling method. Finally, our paper summarizes the common methods for evaluating FS rat models.

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Matrix metalloproteinase, tissue inhibitor of metalloproteinase and transforming growth factor-beta 1 in frozen shoulder, and their changes as response to intensive stretching and supervised neglect exercise

Cited by 69 publications

References 25 publications

Induction of MMP-1 and −3 by cyclical mechanical stretch is mediated by IL-6 in cultured fibroblasts of keratoconus

Induction of MMP-1 and −3 by cyclical mechanical stretch is mediated by IL-6 in cultured fibroblasts of keratoconus

Systematic review of biochemical biomarkers for neck and upper-extremity musculoskeletal disorders

Rat models of frozen shoulder: Classification and evaluation

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