Matrix metalloproteinases 2 and 9 as the factors of head and neck tumor metastases

Кондакова, И. В.; Klisho, E. V.; Савенкова, О. В.; Какурина, Г. В.; Чойнзонов, Е. Л.; Shishkin, D. A.; Mukhamedov, M. R.

doi:10.1134/s1990750808030116

Cited by 3 publications

(4 citation statements)

References 12 publications

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“…The correlation between these MMPs and degree and stage of tumor and lymph node metastasis and poor prognosis are well shown. MMP-9 has shown to be better predictor of poor prognosis compared to MMP-2 (Sun et al, 2007;Kondakova et al, 2008;Gou et al, 2010;Cao et al, 2011;Mallis et al, 2012;Colovic et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Serum Level of Matrix Metalloproteinase-2 and -9 in Patients with Laryngeal Squamous Cell Carcinoma and Clinical Significance

Lotfi¹,

Mohammadi²,

Saniee³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Laryngeal cancer is an important malignancy in head and neck area and squamous cell carcinoma (SCC) is the most common type accounting for 95% of cases. Increase in matrix metalloproteinases (MMPs) in different tumors and their correlation with tumor invasiveness has been documented. However, most studies have evaluated MMP-2 and MMP-9 expression and few have evaluated serum levels. The aim of current study was to evaluate serum levels in patients with laryngeal SCC compared to normal subjects and assess any relation with tumor clinicopathological findings. Materials and Methods: In this case control study, 20 patients with oral SCC and 20 healthy subjects were included. Serum levels of MMP-2 and MMP-9 were compared between groups and correlations with findings including grade (T) and node involvement (N) were evaluated. Results: Patients with laryngeal SCC had significantly higher serum levels of MMP-2 (p=0.01) and MMP-9 (p=0.03) compared to healthy subjects. Patients with higher T stage (T3,4) had significantly higher MMP-2 (p=0.04) and MMP-9 (p=0.01). There was significant positive correlation between serum levels of MMP-2 with T stage (r=0.45, p=0.04) and lymph node involvement (r=0.563, p=0.01) and between levels of MMP-9 with T stage (r=0.527, p=0.01). Conclusions: Our results showed that compared to healthy subjects, both MMP-2 and MMP-9 are significantly increased in serum of laryngeal SCC cases. MMP-2 was correlated with lymph node involvement while MMP-9 has stronger correlation with T stage compared to MMP-2.

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Section: Introductionmentioning

confidence: 99%

Serum Level of Matrix Metalloproteinase-2 and -9 in Patients with Laryngeal Squamous Cell Carcinoma and Clinical Significance

Lotfi¹,

Mohammadi²,

Saniee³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Alireza Lotfi 1 , Ghodrat Mohammadi 1 , Atena Tavassoli 2 *, Mehrnoosh mousaviagdas 1 , Hadi Chavoshi 2 , Lale Saniee 2 1999); however, MMP-9 compared to MMP-2 has shown to be more related to distant metastasis, lymph node involvement and higher stage of the disease (Katayama et al, 2004;de Vicente et al, 2005;Kondakova et al, 2008;Singh et al, 2010;Monteiro-Amado et al, 2013;Vilen et al, 2013;Bedal et al, 2014).…”

Section: Serum Levels Of Mmp9 and Mmp2 In Patients With Oral Squamous Cell Carcinomamentioning

confidence: 99%

“…However, the studies in this regard have usually measured histologic expression of MMPs and not their serum levels (Katayama et al, 2004;de Vicente et al, 2005;Kondakova et al, 2008;Singh et al, 2010;Monteiro-Amado et al, 2013;Vilen et al, 2013;Bedal et al, 2014). There are few studies evaluated different MMPs role in oral SCC in Iran (Elahi et al, 2012;Tadbir et al, 2012;Mohtasham et al, 2013).…”

Section: Serum Levels Of Mmp9 and Mmp2 In Patients With Oral Squamous Cell Carcinomamentioning

confidence: 99%

Serum Levels of MMP9 and MMP2 in Patients with Oral Squamous Cell Carcinoma

Lotfi¹,

Mohammadi²,

Tavassoli³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Squamous cell carcinoma (SCC) is the most common cancer in the oral area. Matrix metalloproteinases (MMPs) and especially MMP-2 and MMP-9 are increased in malignancy and lymph node involvement in oral SCCs. We aimed to evaluate the serum levels of MMP-2 and MMP-9 in patients with oral SCC compared to normal subjects and their relation with clinicopathological findings. Materials and Methods: In this case control study, 20 patients with oral SCC and 20 healthy subjects were included and serum levels of MMP-2 and MMP-9 were compared between groups. Also, the correlation between these markers with clinicopathological findings including grade (T) and node (N) were evaluated. Results: Patients with oral SCC had significantly higher serum levels of MMP-2 (p=0.01) and MMP-9 (p<0.001) compared to healthy subjects. With increase in grade T, MMP-2 was significantly increased (p=0.001), but in the MMP-9 case this was not significant (p=0.27). The levels of MMP-2 (p=0.002) and MMP-9 (p=0.01) in cases with lymph node involvement and that of MMP-2 in subjects with smoking history (p=0.001) were significantly high. There was significantly positive correlation between MMP-2 with grade T tumor (r=0.598, p=0.005), lymph node involvement (r=0.737, p<0.001) and smoking (r=0.674, p=0.001) and also between MMP-9 and lymph node involvement (r=0.474, p=0.03). Conclusions: Both markers are significantly increased in oral SCC compared to healthy subjects. However, MMP-2 was better for evaluating lymph node involvement and tumor grade.

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“…Οι Kondakova και συν. διαπίστωσαν σχέση μεταξύ επιπέδων MMP-9 και TIMP-1 και ανάπτυξης SCC κεφαλής και τραχήλου καθώς και μεταξύ επιπέδων της TIMP-1 του ορού και των ιστών με τη Ν1 τραχηλική μεταστατική νόσο (Kondakova et al 2008). Σε πρόσφατη μελέτη τους οι Huang και συν.…”

Section: α42 Mmps στον καρκινο κεφαλης και τραχηλουunclassified

Μοριακή Ανάλυση Και Διαπίστωση Μεταβολών Δομικών Και Λειτουργικών Μακρομοριακών Συστατικών Στον Καρκίνο Του Λάρυγγα

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Matrix metalloproteinases 2 and 9 as the factors of head and neck tumor metastases

Cited by 3 publications

References 12 publications

Serum Level of Matrix Metalloproteinase-2 and -9 in Patients with Laryngeal Squamous Cell Carcinoma and Clinical Significance

Serum Level of Matrix Metalloproteinase-2 and -9 in Patients with Laryngeal Squamous Cell Carcinoma and Clinical Significance

Serum Levels of MMP9 and MMP2 in Patients with Oral Squamous Cell Carcinoma

Μοριακή Ανάλυση Και Διαπίστωση Μεταβολών Δομικών Και Λειτουργικών Μακρομοριακών Συστατικών Στον Καρκίνο Του Λάρυγγα

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