Matrix Metalloproteinases and Hypertension

Prado, Alejandro Ferraz do; Castro, Michele M.; Gerlach, Raquel Fernanda

doi:10.1007/978-1-4614-9099-9_15

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Mmp and Cardiovascular Diseases1

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2014

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“…Matrix metalloproteinases play an essential role in hypertension . Our group has reported elevated MMP‐2 levels in the thoracic aortas and heart of two‐kidney, one‐clip (2K1C) hypertensive rats.…”

Section: Mmp and Cardiovascular Diseasesmentioning

confidence: 99%

Matrix Metalloproteinases are Involved in Cardiovascular Diseases

Azevedo

Prado

Antonio

et al. 2014

Basic Clin Pharma Tox

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This MiniReview describes the essential biochemical and molecular aspects of matrix metalloproteinases (MMPs) and briefly discusses how they engage in different diseases, with particular emphasis on cardiovascular diseases. There is compelling scientific evidence that many MMPs, especially MMP-2, play important roles in the development of cardiovascular diseases; inhibition of these enzymes is beneficial to many cardiovascular conditions, sometimes precluding or postponing end-organ damage and fatal outcomes. Conducting comprehensive discussions and further studies on how MMPs participate in cardiovascular diseases is important, because inhibition of these enzymes may be an alternative or an adjuvant for current cardiovascular disease therapy.

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Section: Mmp and Cardiovascular Diseasesmentioning

confidence: 99%