Matrix Metalloproteinases: Inflammatory Regulators of Cell Behaviors in Vascular Formation and Remodeling

Chen, Qishan; Jin, Min; Yang, Feng; Zhu, Jiang; Xiao, Qingzhong; Zhang, Li

doi:10.1155/2013/928315

Cited by 392 publications

(347 citation statements)

References 139 publications

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“…Therefore, EPC behavior is greatly regulated by chemical and physical properties of their surrounding ECM. 55 Hanjaya-Putra et al have demonstrated that soft matrix reduces the MMP production by EPCs while increasing cell elongation and extending intracellular vacuoles to open lumen compartments through a signaling pathway involving the activation of the Rho GTPase Cdc42. 56 Not surprisingly, when normal tissue homeostasis becomes imbalanced, as can occur during tissue injury, tissue function can become impaired.…”

Section: Cellular Response To Ecm Stiffness During Tissue Homeostasismentioning

confidence: 99%

Tissue Stiffness Dictates Development, Homeostasis, and Disease Progression

et al. 2015

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ABSTRACT. Tissue development is orchestrated by the coordinated activities of both chemical and physical regulators. While much attention has been given to the role that chemical regulators play in driving development, researchers have recently begun to elucidate the important role that the mechanical properties of the extracellular environment play. For instance, the stiffness of the extracellular environment has a role in orienting cell division, maintaining tissue boundaries, directing cell migration, and driving differentiation. In addition, extracellular matrix stiffness is important for maintaining normal tissue homeostasis, and when matrix mechanics become imbalanced, disease progression may ensue. In this article, we will review the important role that matrix stiffness plays in dictating cell behavior during development, tissue homeostasis, and disease progression.

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Section: Cellular Response To Ecm Stiffness During Tissue Homeostasismentioning

confidence: 99%

Tissue Stiffness Dictates Development, Homeostasis, and Disease Progression

et al. 2015

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“…sponsible for tadpole tail resorption [10][11][12]. Since then, the MMP family has grown to include at least 23 members in humans and 24 in mice.…”

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confidence: 99%

“…Since then, the MMP family has grown to include at least 23 members in humans and 24 in mice. Some of them are not yet fully understood [10,13]. Matrix metalloproteinases are considered members of the multigene metzincin family, which also includes transmembrane and secreted proteins called a disintegrin and metalloproteinases (ADAMs), a disintegrin and metalloproteinase with thrombospondin mofits (ADAMTSs), bone morphogenic protein 1/tolloid-like metalloproteinase (BMPI/ /TLLs) and meprins [14,15].…”

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confidence: 99%

The Significance of Matrix Metalloproteinases in Oral Diseases

et al. 2015

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MMPs are significant in the physiological processes of embryo development, wound healing and differentiation related to tissue remodeling. However, the overexpression of several MMPs is involved in tumor invasion, metastasis, disregulated angiogenesis, inflammation and even cell destruction [1,[5][6][7][8][9]. MMP SubfamiliesThe first metalloproteinase was discovered in 1962 during a study of the ECM degradation re- The Role of MMPsMatrix metalloproteinases (MMPs) belong to a family of structurally related zinc-dependent proteolytic enzymes that are known known to play a key role in the catabolic turnover of extracellular matrix (ECM) components. Research studies to date have indicated that MMPs regulate the activity of several non-ECM bioactive substrates, including growth factors, cytokines, chemokines and cell receptors, which determine the tissue microenvironment. These activities are implicated in a number of essential physiopathological processes AbstractMatrix metalloproteinases (MMPs) belong to a family of structurally related zinc-dependent proteolytic enzymes that are known to play a key role in the catabolic turnover of extracellular matrix (ECM) components. Research studies to date have indicated that MMPs regulate the activity of several non-ECM bioactive substrates, including growth factors, cytokines, chemokines and cell receptors, which determine the tissue microenvironment. Disruption of the balance between the concentration of active matalloproteinases and their inhibitors (TIMPs) may lead to pathological changes associated with uncontrolled ECM turnover, tissue remodeling, inflammatory response, cell growth and migration. This brief review presents some information on MMPs' role in inflammatory, metabolic and cancer abnormalities related to the salivary glands, as well as MMP-related aspects that lead to the formation of human dentinal caries lesions. In oral diseases, the most relevant biological fluid commonly used for diagnosing periodontal diseases is saliva. In diseased patients with significantly higher levels of MMPs in their saliva than healthy people, most extracellular matrix components undergo digestion to lower molecular weight forms. Conventional treatment successfully reduces the levels of MMPs inhibits the progressive breakdown of gingival and periodontal ligament collagens. Beside inflammatory abnormalities like Sjögren's syndrome (SS), a large group of disorders is comprised of cancers, most of them involving the parotid gland (Adv Clin Exp Med 2016, 25, 2, 383-390).

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“…ECM, upon its degradation by MMPs, releases FGFs that are stored or trapped within by MMPs. Otherwise, FGFs may associate with a carrier protein that delivers these FGFs to their respective receptors and in turn activate them [86].…”

Section: Fgf and Fgfrs: Roles In Cancermentioning

confidence: 99%