Matrix Metalloproteinases: Mediators of Tumour-Host Cell Interactions

Diaz, Robert J.; Eichten, Alexandra; Visser, Karin E. de; Coussens, Lisa M.

doi:10.1007/1-4020-3414-8_6

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Vegf: Vascular Endothelial Growth Factor1

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2006

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“…MMPs: matrix metalloproteinases producing extracellular proteases (49,63,71,(77)(78)(79). Matrix metalloproteinases (MMPs) are a large family of proteolytic enzymes that play key roles in cancer progression (80).…”

Section: Vegf: Vascular Endothelial Growth Factormentioning

confidence: 99%

Tumor Stroma and Regulation of Cancer Development

Tlsty

Coussens

2006

Annu. Rev. Pathol. Mech. Dis.

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886

764

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In the past 25 years, a majority of cancer studies have focused on examining functional consequences of activating and/or inactivating mutations in critical genes implicated in cell cycle control. These studies have taught us a great deal about the functions of oncogenes and tumor suppressor genes and the signaling pathways regulating cell proliferation and/or cell death. However, such studies have largely ignored the fact that cancers are heterogeneous cellular entities whose growth is dependent upon reciprocal interactions between genetically altered "initiated" cells and the dynamic microenvironment in which they live. This review highlights the aspects of cancer development that, like organogenesis during embryonic development and tissue repair in adult mammals, are regulated by interactions between epithelial cells, activated stromal cells, and soluble and insoluble components of the extracellular matrix.

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