Matrix Metalloproteinases (MMP‐2) and Tissue Inhibitors of Metalloproteinases (TIMP‐2) in Male Inguinal Hernia Patients at Different Ages

Wang, Dianchen; Zhang, Hongyue; Li, Jianhua; Qiu, Xinguang; Chen, Yake

doi:10.1007/s00268-021-06198-x

Cited by 4 publications

(4 citation statements)

References 25 publications

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“…The details of the included studies are presented in Table 1. Eleven studies [12][13][14][15][16][17][18][19][20][21] focused only on IHs and compared them to a control group. Four studies included patients with IHs and other diseases.…”

Section: Resultsmentioning

confidence: 99%

“…However, there was a lower expression of both TIMP-1 and TIMP-2 in the tissue of patients with IHs when compared to controls. Wang et al [13] measured MMP-2 mRNA and TIMP-2 mRNA expression on the anterior rectus sheath and reported an increase in MMP-2 mRNA levels in both direct and indirect IH patients when compared to the controls. They also observed a reduction of TIMP-2 mRNA levels in patients with direct IHs, resulting in a higher ratio between the two values in both groups of patients with IHs.…”

Section: Timpsmentioning

confidence: 99%

“…They also observed a reduction of TIMP-2 mRNA levels in patients with direct IHs, resulting in a higher ratio between the two values in both groups of patients with IHs. One year later, Wang et al [13] investigated the correlation between MMP-2 and TIMP-2 expression and patient age. They included all patients with a primary inguinal hernia and divided them into study groups based on age.…”

Section: Timpsmentioning

confidence: 99%

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A Systematic Review on the Role of Matrix Metalloproteinases in the Pathogenesis of Inguinal Hernias

Bracale,

Peltrini,

Iacone

et al. 2023

Biomolecules

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The recurrence rate in patients who undergo surgery for abdominal wall hernias (AWHs) is high. AWHs have been hypothesized to be a disease of the extracellular matrix, which is supported by evidence showing a high incidence of AWHs in patients with connective tissue disorders. This study aimed to investigate the most recent literature studies describing the levels of several matrix metalloproteinases (MMPs) in the blood and fascia, with the objective of better clarifying the pathogenetic role of matrix metalloproteinases (MMPs) and their inhibitors in inguinal hernias (IHs). A systematic literature search was conducted using the PubMed, Scopus, and Web of Science electronic databases to identify eligible studies. The identified studies were included in the analysis, and a qualitative synthesis of the results is provided to describe the most recent findings. Seventeen studies were included. An association between MMP-2 and direct IHs has also been demonstrated. MMP-1, MMP-2, MMP-9, MMP-12, and MMP-13 levels were increased in both the serum and fascia of patients with IHs. The analysis of inhibitors showed an increase in tissue inhibitors of metalloproteinases (TIMPs), specifically TIMP-1 in IHs, particularly in direct hernias, and a reduction in TIMP-2 in the biopsy samples of the transversalis fascia. In contrast, a reduction in TIMP-1 and an increase in TIMP-2 levels have been reported only in the serum of patients with IHs. Metalloproteinases play a crucial role in the pathogenesis of IHs. The analysis of other molecules, such as TIMPs or their correlation with specific genes, is enhancing our understanding of the pathophysiology of IHs. However, more prospective studies, including comprehensive clinical and laboratory data collection, are required to confirm the relationship between the studied biomarkers and the risk of IHs.

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Section: Resultsmentioning

confidence: 99%

Section: Timpsmentioning

confidence: 99%

Section: Timpsmentioning

confidence: 99%

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A Systematic Review on the Role of Matrix Metalloproteinases in the Pathogenesis of Inguinal Hernias

Bracale,

Peltrini,

Iacone

et al. 2023

Biomolecules

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show abstract

“…Previous research has primarily concentrated on investigating non-genetic risk factors associated with the development of this condition, including male sex, old age, occupational mechanical exposures, and lifestyle factors 22 , or genetic evidence, including several gene expressions in patients with familial inguinal hernia, such as MMP-2 23 , TIMP-2 24 , Actc1 25 , and TBX3 26 . Some of these have also been identi ed in individuals with sporadic inguinal hernia, suggesting a possible genetic predisposition to inguinal hernia.…”

Section: Discussionmentioning

confidence: 99%

Exploring Obesity Management as a Novel Approach for Preventing Inguinal Hernias: Evidence from a Mendelian Randomization Study and Systematic Review

Deng,

Zhou,

Zhang

et al. 2024

Preprint

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Background: The relationship between obesity and the risk of developing inguinal hernias (IH) is still unclear. This study aimed to examine the role of different types of obesity in IH risk, with the potential for obesity management as a new approach to preventing IH. Methods: A two-sample Mendelian randomization (MR) analysis and replicated MR analysis were conducted to assess the causal effect of obesity on IH risk. Summary data on genetically determined obesity-related traits, including body mass index (BMI), waist circumference (WC), hip circumference (HC), and waist-to-hip ratio (WHR), were collected from large-scale consortia. Multivariable MR was performed to estimate the independent effects on IH risk. Additionally, a systematic review of observational studies identified from PubMed, Embase, and Web of Science databases was conducted to evaluate the associations between different obesity types and IH, covering the period from inception to November 22, 2023. Results: The findings revealed that increased BMI, WC, and HC (P < 0.05) were associated with a lower risk of IH. The replicated and multivariable MR analyses consistently indicated that BMI exhibited a similar direction and magnitude of effect as observed in the univariable MR analysis [odds ratio (OR) = 0.940-0.989], while WC was associated with a higher risk of IH (OR = 1.018-1.099). The systematic review results supported BMI as a protective factor against inguinal hernia. However, there was limited evidence supporting the causal role of HC and WHR in IH risk. Conclusion: Genetically determined BMI and WC demonstrate a causal relationship with IH risk, providing new insights into potential underlying mechanisms. These results suggest that increasing overall or reducing abdominal obesity may be beneficial for preventing IH.

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Risk factors of recurrence after incisional hernia preperitoneal repair: a long-term retrospective single-center cohort study

Lin,

Shi,

Yang

et al. 2024

Langenbecks Arch Surg

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Matrix Metalloproteinases (MMP‐2) and Tissue Inhibitors of Metalloproteinases (TIMP‐2) in Male Inguinal Hernia Patients at Different Ages

Cited by 4 publications

References 25 publications

A Systematic Review on the Role of Matrix Metalloproteinases in the Pathogenesis of Inguinal Hernias

A Systematic Review on the Role of Matrix Metalloproteinases in the Pathogenesis of Inguinal Hernias

Exploring Obesity Management as a Novel Approach for Preventing Inguinal Hernias: Evidence from a Mendelian Randomization Study and Systematic Review

Risk factors of recurrence after incisional hernia preperitoneal repair: a long-term retrospective single-center cohort study

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