Matrix metalloproteinases, tissue inhibitors of metalloproteinases, and growth factors regulate the aggressiveness and proliferative activity of keratocystic odontogenic tumors

Common Matrix Metalloproteinases ( M MP - 8, -9, -25, and -26) Cannot Explain Dentigerous Cyst Expansion

“…It has been demonstrated that enhanced expression of MMPs is associated with aggressively behaving odontontogenic cysts type, earlier called keratocyst, currently keratocystic odontogenic tumour [14,15]. MMPs are also connected to several other bone destructive conditions [3,6,13,14].…”

“…These enzymes seem to take part in the bone destruction in more aggressively behaving lesions such as keratocysctic odontogenic tumours and ameloblastomas since their MMP levels are clearly higher when compared to DC [3,14,15]. This suggests the cyst wall being the active counterpart in bone destruction and remodeling.…”

Matrix metalloproteinase expression in keratocystic odontogenic tumors and primary cells

“…In sharp contrast, MMP-7 and MMP-26 were unable to be detected in our KCOT populations (data not shown). MMP-2 and 9 proteins were detected by immunostaining in KCOT and calcifying cystic odontogenic tumors, and MMP-9 was detected in radicular cysts, dentigerous cysts, KCOTs, and ameloblastomas (7,8). In one study, MMP-9 was more frequently expressed in the tumor-associated stroma of KCOTs (60%) then the tumor epithelium (10%).…”

“…Roles attributed to MMPs in tumor development include regulation of tumor growth by mediating the release of stimulating growth factors into the tumor microenviroment (e.g. insulin-like growth factors, epidermal growth factor receptor ligands; MMP-1, 2, 3,7,9,11,19), promoting angiogenesis by degrading the extracellular matrix and increasing availability to vascular endothelial growth factor (MMP-1, 2, 7, 9, and 14) and supporting cell migration and invasion by promoting epithelial-to-mesenchymal transition allowing cells to decrease cell-cell adhesion (MMP-2, 3, 9, 13, 14). Of these MMPs Earlier studies have identified the expression of MMP-1, 2, 9, 13, and 26 in some KCOTs.…”

Perfil de expressão das metaloproteinases de matriz (MMPs) e seus inibidores (TIMPs e RECK) em tumores odontogênicos benignos

“…Muitos estudos mostram a participação das MMPs e TIMPs na progressão dos tumores odontogênicos pelo remodelamento da MEC (Takata et al, 2000a;Vaananen et al, 2001;Kubota et al, 2002;Bast et al, 2003;Kumamoto et al, 2003;Pinheiro et al, 2004a;Cavalcante et al, 2008;Miyagi et al, 2008;Gong et al, 2009;Nonaka et al, 2009;Ribeiro et al, 2009a;Zhang et al, 2009a;Leonardi et al, 2010;Qian et al, 2010;Shen et al, 2010;Siqueira et al, 2010;Henriques et al, 2011;Pinheiro et al, 2011;Ribeiro et al, 2011;Ribeiro et al, 2012).…”