In this paper, a four-port compact active duplexer based on a complimentary split ring resonator (CSRR) and interdigital loaded microstrip coupled lines (CSRR-IL MCL) is presented. Interdigital capacitor is used on the top layer of the proposed structure and CSRR transmission lines are used on the bottom layer of the coupled lines in order to increase the coupling of the proposed circuit and create triple band resonances, respectively. The proposed active duplexer has one input port and three output ports operating in three distinct operation frequencies which are 1.4 GHz, 1.8 GHz, and 3.2 GHz. The active duplexer is designed to target LTE applications which are prevalent among the new technologies and devices. The input signal is split in terms of frequency into the three designed frequencies and is amplified by 13 dB gain of the amplifiers placed at the output ports. The fractional bandwidths of the proposed structure at 1.4 GHz, 1.8 GHz, and 3.2 GHz are 5.2%, 2.8%, and 9.4%, respectively. It is worth mentioning that the size of the proposed active duplexer is 0.29λ 0 × 0.38λ 0 . The design guide of the proposed structure is presented, and it will be shown that the simulation as well as the measurement results of the proposed active duplexer have an acceptable agreement with each other. It should be noted that the VSWR of the proposed structure is less than 1.5 which means that the active duplexer has low return loss, and it is the plus point of it.