Matrix Stiffness Regulated Endoplasmic Reticulum Stress-mediated Apoptosis of Osteosarcoma Cell through Ras Signal Cascades

Deng, Huan; Shu, Xuedong; Wang, Yao; Zhang, Junwei; Yin, Yue; Wu, Fang; He, Jing

doi:10.1007/s12013-023-01184-7

Cited by 2 publications

(1 citation statement)

References 47 publications

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“…32,33 For example, extracellular matrix elasticity could regulate the apoptosis of osteosarcoma cells through RAS signal cascade and mediate the malignant phenotype of normal breast epithelial cells. 34,35 The observed additional involvement of MAPK and Wnt signaling pathways however suggest the somewhat different mechanism of mechanotransduction. The MAPK pathway was usually activated by upstream Rho family proteins and was involved in cytoskeletal organization and p53 protein regulation, and further affected DNA repair and apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Effects of matrix viscoelasticity on cell–matrix interaction, actin cytoskeleton organization, and apoptosis of osteosarcoma MG-63 cells

Deng,

Wang,

Yin

et al. 2024

J. Mater. Chem. B

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Section: Discussionmentioning

confidence: 99%

Effects of matrix viscoelasticity on cell–matrix interaction, actin cytoskeleton organization, and apoptosis of osteosarcoma MG-63 cells

Deng,

Wang,

Yin

et al. 2024

J. Mater. Chem. B

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Cancer cell response to extrinsic and intrinsic mechanical cue: opportunities for tumor apoptosis strategies

Shu,

Deng,

Zhang

et al. 2024

Regenerative Biomaterials

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Increasing studies have revealed the importance of mechanical cues in tumor progression, invasiveness, and drug resistance. During malignant transformation, changes manifest in either the mechanical properties of the tissue or the cellular ability to sense and respond to mechanical signals. The major focus of the review is the subtle correlation between mechanical cues and apoptosis in tumor cell from a mechanobiology perspective. To begin, we focus on the intracellular force, examining the mechanical properties of the cell interior, and outlining the role that the cytoskeleton and intracellular organelle-mediated intracellular forces play in tumor cell apoptosis. This paper also elucidates the mechanisms by which extracellular forces guide tumor cell mechanosensing, ultimately triggering the activation of the mechanotransduction pathway and impacting tumor cell apoptosis. Finally, a comprehensive examination of the present status of design and development of anti-cancer materials targeting mechanotransduction is presented, emphasizing the underlying design principles. Furthermore, the paper underscores the need to address several unresolved inquiries to enhance our comprehension of cancer therapeutics that target mechanotransduction.

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Matrix Stiffness Regulated Endoplasmic Reticulum Stress-mediated Apoptosis of Osteosarcoma Cell through Ras Signal Cascades

Cited by 2 publications

References 47 publications

Effects of matrix viscoelasticity on cell–matrix interaction, actin cytoskeleton organization, and apoptosis of osteosarcoma MG-63 cells

Effects of matrix viscoelasticity on cell–matrix interaction, actin cytoskeleton organization, and apoptosis of osteosarcoma MG-63 cells

Cancer cell response to extrinsic and intrinsic mechanical cue: opportunities for tumor apoptosis strategies

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