Maturation of human neonatal CD4+ and CD8+ T lymphocytes into Th1/Th2 effectors

Delespesse, Guy; Yang, Liang; Ohshima, Yusei; Demeure, Christian E.; Shu, Uno; Byun, Dae Gyoo; Sarfati, Marika

doi:10.1016/s0264-410x(98)00101-7

Cited by 122 publications

(87 citation statements)

References 36 publications

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“…The results obtained in this trial agree with studies accomplished on human immunehematology, which have reported lower quantities of pan-T cells, T-auxiliary and Tcytotoxic cells in the UCB, compared to those found in the peripheral blood of newly born babies and adults (Motley et al, 1996;Dimitriou et al, 1998;Schultz et al, 2000). However, other researchers found higher quantities of T, NK, and B cells when compared to the peripheral blood of adults (Szabolcs et al, 2003).…”

Section: Althoughsupporting

confidence: 89%

“…On human immune-hematology, the study of T cells in the UCB has a considerable importance (Lin and Chao, 2001), in a way that many researches have been conducted to establish the immunophenotypic characteristics of lymphocyte populations and subpopulations in the umbilical cord blood (Dimitriou et al, 1998;Motley et al, 1996;Schultz et al, 2000).…”

Section: Resultsmentioning

confidence: 99%

“…The umbilical cord blood (UCB) is a rich source of stem cells with high capacity of selfrenovation and proliferation (Dimitriou et al, 1998). The umbilical cord blood transplants lead to few or none occurrences of the graft-versushost disease (GVHD), when compared to bone marrow transplants; a fact that is probably related to the functional immaturity of the UCB T cells (Lu et al, 1996;Lin and Chao, 2001).…”

Section: Introductionmentioning

confidence: 99%

“…In human immune-hematology, many authors have quantified lymphocytes and its different subpopulations in the UCB, using the immunophenotyping and cytofluorimetric reading (Dimitriou et al, 1998;Motley et al, 1996;Szabolcs et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

“…Researches have revealed that there is a lower quantity of T CD3, CD4 and CD8 lymphocytes in the human UCB, when compared to the adult peripheral blood, as well as a higher proportion of CD4:CD8 (Dimitriou et al, 1998;Motley et al, 1996). It has also been reported a high quantity of immature cells, not only among the T lymphocyte subpopulations, but among B lymphocytes (Szabolcs et al, 2003), in addition to some populations not found in adults peripheral blood, or found in few numbers, like CD19 + 10 + and CD8 + 3 -cells (Motley et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

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T lymphocyte subsets of the umbilical cord blood of dogs

Cápua

Santana

Nakage

et al. 2009

Arq. Bras. Med. Vet. Zootec.

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The hematological parameters red blood cells (RBC) and total white blood cells (WBC) counts, hematocrit, hemoglobin concentration, and RBC indexes (median corpuscular volume and median corpuscular hemoglobin concentration) were determined and T CD5 + lymphocytes and CD4 + and CD8 + subpopulations of the umbilical cord blood (UCB) of dogs were quantified by the cytofluorimetric technique. Nine adult Beagles, from two do five-year old, were used as control. The umbilical cord blood (UCB) was collected from 20 neonate dogs. The method for the UCB collection was adequate to obtain sufficient quantity of blood for the accomplishment of the hematological analyses and lymphocyte quantification. Cytoscopic preparations of the UCB suggested high erythropoietic activity. There was no difference for the global leukocyte and lymphocyte counts between the groups. UCB T lymphocyte counts were lower than those obtained for adult dogs. The proportion of CD4:CD8 showed a great dominance of T CD4 + cells over T CD8 + lymphocytes in UCB.

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Section: Althoughsupporting

confidence: 89%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

T lymphocyte subsets of the umbilical cord blood of dogs

Cápua

Santana

Nakage

et al. 2009

Arq. Bras. Med. Vet. Zootec.

View full text Add to dashboard Cite

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Type 1-like immune response is found in children with respiratory syncytial virus infection regardless of clinical severity

et al. 2000

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The immunological response of infants younger than six months to infection with respiratory syncytial virus (RSV) was studied in relation to clinical severity. IL-6 and IL-8 were found more frequently and at higher levels in the plasma samples of more severely ill patients and no significant differences were found in the levels of cytokines differentiating between Type 1 and Type 2 responses. Cellular infiltrates in nasopharyngeal washings consisted mainly of polymorphonuclear granulocytes and monocytes. Eosinophils, IgE positive cells and tryptase positive cells were found sporadically. Analyses of RSV stimulated T cell cultures established from peripheral blood mononuclear cells, for intracellular and secreted cytokines showed that, irrespective of clinical severity, the responses were dominated by the production of IFN-gamma, and that only low levels of IL-4 and IL-10 were detectable. Collectively these data do not indicate an association between clinical severity and a Type 2-like T cell response.

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