Maturation of the gut microbiome and risk of asthma in childhood

Stokholm, Jakob; Blaser, Martin J.; Thorsen, Jonathan; Rasmussen, Morten Arendt; Waage, Johannes; Vinding, Rebecca K.; Schoos, Ann‐Marie Malby; Kunøe, Asja; Fink, Nadia R.; Chawes, Bo; Bønnelykke, Klaus; Brejnrod, Asker; Mortensen, Martin Steen; Al‐Soud, Waleed Abu; Sørensen, Søren J.; Bisgaard, Hans

doi:10.1038/s41467-017-02573-2

Cited by 452 publications

(496 citation statements)

References 70 publications

(100 reference statements)

Supporting

Mentioning

452

Contrasting

Unclassified

Order By: Relevance

“…We found that tracheal colonization in the neonatal period was associated with a decreased risk of asthma. The relationship between lung and gut microbiota and childhood asthma appears to be complex . Nevertheless, our results can be viewed as lending support to the hypothesis that reduced exposure to bacteria in early life may increase the risk of asthma and other atopic diseases …”

Section: Discussionsupporting

confidence: 77%

Risk factors for chronic lung disease and asthma differ among children born extremely preterm

Jackson

Allred

Laughon

et al. 2018

Pediatric Pulmonology

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 77%

Risk factors for chronic lung disease and asthma differ among children born extremely preterm

Jackson

Allred

Laughon

et al. 2018

Pediatric Pulmonology

View full text Add to dashboard Cite

show abstract

“…The gradual increase of the butyrate levels and the emergence of the butyrogenic community in the gut could be important for gut maturation, as aberrant microbial composition and/or SCFA production is associated with colicky symptoms and atopy diseases in infants (Arrieta et al 2015, de Weerth et al 2013, Stokholm et al 2018, Wopereis et al 2017. …”

Section: Microbial Network Leading To Butyrate Productionmentioning

confidence: 99%

“…An aberrant SCFA profile and/or microbial composition are/is shown to be associated with colicky symptoms and allergy in infants (Arrieta et al 2015, de Weerth et al 2013, Stokholm et al 2018, Wopereis et al 2017. A significant decrease of Lachnospira, Veillonella, Faecalibacterium, and Rothia genera, as well as reduced levels of faecal acetate at 3 months old have been observed in children at risk of asthma (Arrieta et al 2015).…”

Section: Chaptermentioning

confidence: 99%

Cross-feeding interactions of gut symbionts driven by human milk oligosaccharidesand mucins

Chia¹

View full text Add to dashboard Cite

Chapter 4Microbial metabolic networks at the mucus layer lead to dietindependent butyrate and vitamin B12 production by intestinal symbionts 71 Chapter 5Deciphering trophic interaction between Akkermansia muciniphila and the butyrogenic gut commensal Anaerostipes caccae using a metatranscriptomic approach 97 Chapter 6General discussion 123 Chapter 7 Thesis summary & Nederlandse samenvatting 143 Appendices References 153Co-author affiliations 179Acknowledgements 183About the author 184List of publications 185 VLAG training activities 186Chapter 1 General introduction and thesis outlineChapter 1 2 General introductionHumans can be considered holobionts, consisting of cells from the host and an even larger number of microorganisms (Postler and Ghosh 2017). The majority of microbes are residing in the gut (Sender et al 2016). The human gut microbiota is a complex ecosystem consisting of bacteria, archaea, microeukaryotes and viruses (Clemente et al 2012). Over 2000 species-level phylotypes (prokaryotes including bacteria and archaea) have been detected for the gut microbiota, with each individual estimated to host at least 160 species (Qin et al 2010, Zoetendal et al 2008. The gut microbiota may impact the well-being of human and susceptibility for diseases by interacting with our metabolic, immune and neurological system (Honda and Littman 2016, Koh et al 2016, Rogers et al 2016. Furthermore, the gut microbiota contributes to a variety of metabolic functions and can be seen as an essential part of our digestive system (El Kaoutari et al 2013). Bacterial symbionts allow the human hosts to utilise inaccessible nutrients by converting complex substrates to short chain fatty acid (SCFA) and vitamins (Fisher et al 2017). Bacterial-derived SCFAs are estimated to contribute about 10% of our daily caloric requirement (Bergman 1990). While all SCFAs are vital for maintaining gut homeostasis, butyrate is of particular interest because it has been attributed to a range of health-promoting functions. Butyrate is the primary energy source for colonic epithelial cells and is associated with the enhancement of colonic barrier function, increase of satiety, pain relief, anti-inflammatory responses, and protection against colorectal cancer (Banasiewicz et al 2013, Bolognini et al 2016, Donohoe et al 2011, Furusawa et al 2013, Goncalves and Martel 2013.Considering the physiological benefits of butyrate to human health, this thesis investigates the microbial interaction of gut symbionts that support butyrate production driven primarily by the host produced glycans in human milk and mucus. Glycans are compounds consisting of an array of glycosidically linked monosaccharides (monosaccharides and disaccharides are collectively termed sugars) such as human milk oligosaccharides (HMOS) and mucins (Varki and Kornfeld 2017). HMOS present in mother milk are the major compositional and functional driver of the infant gut microbiota (Backhed et al 2015). Mucin glycans covering the intestinal lining create a stable niche for bacterial coloni...

show abstract

“…Furthermore, there was a significant difference in the structure of microbial populations at one year in non‐asthmatic children compared with children who had asthma at age five, which was positively associated with higher abundance of Veillonella and lower abundance of Roseburia, Alistipes, Faecalibacterium, Bifidobacterium, Ruminococcus, Lachnospiraceae incertae sedis and Dialister. Interestingly, this association between developing asthma before age 5 and the structure of microbial population was only confined to the children who were born to asthmatic mothers . The association between asthmatic mothers and development of asthma in children has been explained through dysbiosis in a few studies which are discussed in the following section.…”

Section: Dysbiosis In Infancy and Asthma Later In Lifementioning

confidence: 99%

The role of gut microbiota in atopic asthma and allergy, implications in the understanding of disease pathogenesis

et al. 2020

View full text Add to dashboard Cite

Asthma is a clinical syndrome characterized by chronic airway inflammation. There is mounting evidence on the role of microbiota in the development of asthma. This review focuses on the role of microbiota in maintaining the integrity of the epithelia and their role in regulating the immune response. The review compiles data from multiple studies on the role of microbiota in the innate immune response and the development and differentiation of CD4+ T cells, a major component of the adaptive arm of the immune response. As a result of dysbiosis, invariant natural killer T cells may induce T helper 2 cell differentiation and immunoglobulin E isotype switching through the release of interleukin‐4 and interleukin‐13. Furthermore, degradation of immunoglobulin A antibodies, increased circulating mast cells and basophils, and inflammation are among other mechanisms by which dysbiosis can induce or exacerbate asthma. After explaining the underlying mechanisms, the review derives conclusions from studies that investigate dysbiosis in infancy and the development of asthma later in life. The review also includes studies that investigate asthmatic mothers and the development of asthma in children and the role of dysbiosis in that regard. Finally, the review explains the statistical relationship between eczema and asthma through multiple studies that investigate the role of dysbiosis in both atopic states. This review provides insight into the role of dysbiosis in asthma, and an understanding that is required to establish clinical trials which aim to modulate the gut microbiota as a means of preventing and treating asthma.

show abstract

Maturation of the gut microbiome and risk of asthma in childhood

Cited by 452 publications

References 70 publications

Risk factors for chronic lung disease and asthma differ among children born extremely preterm

Risk factors for chronic lung disease and asthma differ among children born extremely preterm

Cross-feeding interactions of gut symbionts driven by human milk oligosaccharidesand mucins

The role of gut microbiota in atopic asthma and allergy, implications in the understanding of disease pathogenesis

Contact Info

Product

Resources

About