Maturational Aspects of Epilepsy Mechanisms and Consequences for the Immature Brain

Sánchez, Raúl Hernández; Jensen, Frances E.

doi:10.1046/j.1528-1157.2001.12000.x

Cited by 186 publications

(155 citation statements)

References 108 publications

(138 reference statements)

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“…We suggest that developmental changes in the NMDA receptors subunit composition can at least partly explain the increased probability to ILE induction in the immature hippocampus. Increased expression of AMPA receptor and underdeveloped inhibitory synaptic system in the immature brain could be among other contributing factors [15].…”

Section: Resultsmentioning

confidence: 99%

Effect of altered extracellular magnesium concentration on the neuronal activity in different hippocampal regions of immature rats

Власюк¹,

Romanov²,

Isaev³

et al. 2017

Fiziol Zh

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Section: Resultsmentioning

confidence: 99%

Effect of altered extracellular magnesium concentration on the neuronal activity in different hippocampal regions of immature rats

Власюк¹,

Romanov²,

Isaev³

et al. 2017

Fiziol Zh

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“…However, GABAA receptors activation causes membrane depolarization in the first postnatal weeks, rather than hyperpolarization typical for mature GABA-ergic synapses. This process is related to maturation changes in the transmembrane chloride ion gradient [11]. Thus we can discuss if GABA-ergic interneurons dysfunction due to SCN1A mutation resulting in increased susceptibility to seizures in post neonatal age, might diminish it during the neonate period.…”

Section: Discussionmentioning

confidence: 99%

Neonatal Seizures do not Exclude Dravet Syndrome Diagnosis

Szczepanik¹,

Terczyńska²

2016

J Neurol Neurophysiol

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“…This is dependent on a number of different neurotransmitter systems, including glutamate receptors (N-methyl-D-aspartate [NMDA], a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid [AMPA], and kainite receptors) and c-amino-butyric acid (GABA) receptors. Evidence [7][8][9][10][11][12] from the literature regarding these physiological changes is summarized in Table I. This state of increased excitation permits synaptic formation, plasticity, and neuronal remodelling.…”

Section: Pathophysiologymentioning

confidence: 99%

Neonatal seizures in hypoxic–ischaemic encephalopathy – risks and benefits of anticonvulsant therapy

Shetty

2015

Develop Med Child Neuro

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The risk of seizures is at its highest during the neonatal period, and the most common cause of neonatal seizures is hypoxic–ischaemic encephalopathy (HIE). This enhanced vulnerability is caused by an imbalance in the expression of receptors for excitatory and inhibitory neurotransmission, which is age dependent. There has been progress in detecting the electrophysiological abnormalities associated with seizures using amplitude‐integrated electroencephalography (aEEG). Data from animal studies indicate a variety of risk factors for seizures, but there are limited clinical data looking at the long‐term neurodevelopmental consequences of seizures alone. Neonatal seizures are also associated with increased risk of further epileptic seizures; however, it is less clear whether or not this results from an underlying pathology, and whether or not seizures confer additional risk. Phenobarbital and phenytoin are still the first‐line antiepileptic drugs (AEDs) used to treat neonatal seizures, although they are effective in only one‐third of affected infants. Furthermore, based on findings from animal studies, there are concerns regarding the risks associated with using these AEDs. Clinicians face a difficult challenge because, although seizures can be easily identified using aEEG, treatment options are limited, and there are uncertainties regarding treatment outcomes. There is a need to obtain long‐term follow‐up data, comparing groups of infants treated with or without current therapies. If these analyses indicate a definite benefit of treating neonatal seizures, then novel therapeutic approaches should be developed.

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Maturational Aspects of Epilepsy Mechanisms and Consequences for the Immature Brain

Cited by 186 publications

References 108 publications

Effect of altered extracellular magnesium concentration on the neuronal activity in different hippocampal regions of immature rats

Effect of altered extracellular magnesium concentration on the neuronal activity in different hippocampal regions of immature rats

Neonatal Seizures do not Exclude Dravet Syndrome Diagnosis

Neonatal seizures in hypoxic–ischaemic encephalopathy – risks and benefits of anticonvulsant therapy

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