Mature and activated osteoclasts exist in the synovium of rapidly destructive coxarthrosis

Ogawa, Kenji; Mawatari, Masaaki; Komine, Mitsunori; Shigematsu, Masamori; Kitajima, Masaru; Kukita, Akiko; Hotokebuchi, Takao

doi:10.1007/s00774-007-0761-0

Cited by 39 publications

(36 citation statements)

References 27 publications

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“…105 moreover, mature, activated osteoclasts have been found in rapidly destructive oa that are not found in common oa. 106 these data show that the synovium has a major role in the osteoclastogenesis of subchondral bone in oa. 106 …”

Section: Histopathological Features Of Oa Synovitismentioning

confidence: 88%

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The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

2010

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Osteoarthritis (OA), one of the most common rheumatic disorders, is characterized by cartilage breakdown and by synovial inflammation that is directly linked to clinical symptoms such as joint swelling, synovitis and inflammatory pain. The gold-standard method for detecting synovitis is histological analysis of samples obtained by biopsy, but the noninvasive imaging techniques MRI and ultrasonography might also perform well. The inflammation of the synovial membrane that occurs in both the early and late phases of OA is associated with alterations in the adjacent cartilage that are similar to those seen in rheumatoid arthritis. Catabolic and proinflammatory mediators such as cytokines, nitric oxide, prostaglandin E(2) and neuropeptides are produced by the inflamed synovium and alter the balance of cartilage matrix degradation and repair, leading to excess production of the proteolytic enzymes responsible for cartilage breakdown. Cartilage alteration in turn amplifies synovial inflammation, creating a vicious circle. As synovitis is associated with clinical symptoms and also reflects joint degradation in OA, synovium-targeted therapy could help alleviate the symptoms of the disease and perhaps also prevent structural progression.

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Section: Histopathological Features Of Oa Synovitismentioning

confidence: 88%

“…106 these data show that the synovium has a major role in the osteoclastogenesis of subchondral bone in oa. 106 …”

Section: Histopathological Features Of Oa Synovitismentioning

confidence: 88%

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

2010

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“…The existing histological studies in the literature demonstrate osteoclasts at the sites of granulomatous lesions in bone marrow in the focal destructive portion of the femoral heads . Moreover, Ogawa et al showed that in RDHD, mature osteoclasts were also present not only in direct vicinity of the destructive lesions but also in the synovium. Komiya detected elevated interleukin (Il‐1beta) and metalloproteinase levels in the joint fluid…”

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confidence: 90%

Massive accumulation of osteoclastic giant cells in rapid destructive hip disease

Seitz

Zustin

Amling

et al. 2014

Journal Orthopaedic Research

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ABSTRACT:The term rapid destructive hip disease (RDHD) designates a rare coxarthropathy characterized by a rapid destruction of the femoral head within a few weeks to several months. The etiology and pathogenesis of RDHD are not understood. The goal of this study was to define the histological and histomorphometric hallmarks of RDHD to provide a basis for a deeper understanding of the underlying mechanisms. Fifteen consecutive RDHD patients (mean age 78.9 AE 6.4 years, 14 females) demonstrated the characteristic radiographic appearance of vanishing femoral head bone stock without signs of reactive anabolic changes. Histologic and histomorphometric analyses revealed severe bone resorption with significantly increased numbers of morphologically altered giant osteoclasts, the formation of giant cell granulomas both in bone marrow and the synovium and significantly increased osteoblast numbers and osteoid as compared to controls with primary osteoarthritis (OA). These results suggest that in RDHD, an unknown stimulus leads to a massive activation of osteoclasts and this in turn provokes a reactive increase in osteoblast activity that is too weak to counteract the rapid destruction of the hip, thus providing a rationale for a prospective systematic search for the stimuli upstream of the massively increased osteoclast activation in RDHD. ß

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“…After excluding those known pathomechanisms, it is believed that there is unknown other etiologies in RDC. Ogawa et al revealed that mature and activated osteoclasts exist only in the synovium of RDC and not in OA synovium [2]. They suggest that underlying mechanism of RDC might associate with osteoclastogenesis in the synovium.…”

Section: Discussionmentioning

confidence: 99%

“…It has been characterized as rapid joint destruction within 6 to 12 months, leading to striking joint deformity. Recent studies suggest multiple pathogenesis in rapid hip osteoarthritis development including abnormal cell population in the joint fluid [2, 3] and subchondral insufficiency fracture (SIF) [4]. But the exact mechanism of RDC is still not clear.…”

Section: Introductionmentioning

confidence: 99%

Rapid Hip Osteoarthritis Development in a Patient with Anterior Acetabular Cyst with Sagittal Alignment Change

Homma

Baba

Sumiyoshi

et al. 2014

Case Reports in Orthopedics

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Rapidly destructive coxarthrosis (RDC) is rare and develops unusual clinical course. Recent studies suggest multiple possible mechanisms of the development of RDC. However the exact mechanism of RDC is still not clear. The difficulty of the study on RDC is attributed to its rareness and the fact that the data before the onset of RDC is normally unavailable. In this report, we presented the patient having the radiographic data before the onset who had rapid osteoarthritis (OA) development after contralateral THA, which meets the current criteria of RDC. We thought that the increased posterior tilt of the pelvis after THA reinforced the stress concentration at pre-existed anterior acetabular cyst, thereby the destruction of the cyst was occurred. As a result the rapid OA was developed. We think that there is the case of rapid osteoarthritis developing due to alternating load concentration by posterior pelvic tilt on preexisting anterior acetabular cyst such as our patient among the cases diagnosed as RDC without any identifiable etiology. The recognition of sagittal alignment changes and anterior acetabular cyst may play important role in prediction and prevention of the rapid hip osteoarthritis development similar to RDC.

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Mature and activated osteoclasts exist in the synovium of rapidly destructive coxarthrosis

Cited by 39 publications

References 27 publications

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

Massive accumulation of osteoclastic giant cells in rapid destructive hip disease

Rapid Hip Osteoarthritis Development in a Patient with Anterior Acetabular Cyst with Sagittal Alignment Change

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