Recently, time-lapse seismic (4D seismic) has been steadily used to demonstrate the relation between field depletion and 4D seismic response, subsequently to have more efficient field management. A key component of the reservoir monitoring is the knowledge of fluid movement and pressure variations. This information is vital to assist infill drillings and a trustworthy source to update reservoir models, consequently improving model-based reservoir management and decision-making process. However, in practice the 4D seismic interpretation of reservoirs with multipart production regime possesses ambiguities through different levels of uncertainty. Complex nature of some 4D seismic signals emphasizes the roles of competing effects, geology, rock and fluid interactions. Hence, a reliable 4D interpretation requires an interdisciplinary approach entailing data analysis and insights from geophysics, engineering and geology. In this research, a step-wise workflow was introduced to reduce uncertainties in the 4D seismic interpretation and provide diagnoses to perform better reservoir surveillance. In parallel, the workflow expresses the use of engineering data analysis to conduct a consistent interpretation and encompasses the 3D and 4D seismic attributes with engineering data analysis. This study is implemented in a Brazilian heavy-oil offshore field where production started in 2013. The field experienced intense production activity up to 2016, making the deep-water field an ideal candidate to explore the challenges in interpreting complex 4D signals. Beyond these challenges, significant understanding of reservoir behavior is obtained and suggestions are made to improve the reservoir simulation model, which could support reservoir engineers with data assimilation applications.