Mature silkworm powders ameliorated scopolamine-induced amnesia by enhancing mitochondrial functions in the brains of mice

Nguyen, Phuong; Kim, Kee‐Young; Kim, A‐Young; Choi, Bo-Hey; Osabutey, Angelina F.; Park, Young Han; Lee, Hyun–Tai; Ji, Sang Deok; Koh, Young Ho

doi:10.1016/j.jff.2020.103886

Cited by 14 publications

(11 citation statements)

References 38 publications

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“…Currently, this processing technique remains invalidated although valuable for nutritional security. Furthermore, steamed and freeze-dried mature silkworm powder exhibits different pharmacological effects [ 125 ] as calorie restriction mimetics [ 126 ], including enhanced mitochondrial functions in the brain [ 127 ].…”

Section: Nutrient Contentsmentioning

confidence: 99%

Chemical Composition, Nutrient Quality and Acceptability of Edible Insects Are Affected by Species, Developmental Stage, Gender, Diet, and Processing Method

Meyer-Rochow

Gahukar²,

Ghosh

et al. 2021

Foods

151

116

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Edible insects have been considered as either nutritious food itemsper se, or as wholesome ingredients to various dishes and components of traditional subsistence. Protein, fat, mineral and vitamin contents in insects generally satisfy the requirements of healthy food, although there is considerable variation associated with insect species, collection site, processing method, insect life stage, rearing technology and insect feed. A comparison of available data (based on dry weight) showed that processing can improve the nutrient content, taste, flavour, appearance and palatability of insects, but that there are additional factors, which can impact the content and composition of insect species that have been recommended for consumption by humans. This review focuses on factors that have received little attention in connection with the task to improve acceptability or choice of edible insects and suggests ways to guarantee food security in countries where deficiencies in protein and minerals are an acute and perpetual problem. This review is meant to assist the food industry to select the most suitable species as well as processing methods for insect-based food products.

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Section: Nutrient Contentsmentioning

confidence: 99%

Chemical Composition, Nutrient Quality and Acceptability of Edible Insects Are Affected by Species, Developmental Stage, Gender, Diet, and Processing Method

Meyer-Rochow

Gahukar²,

Ghosh

et al. 2021

Foods

151

116

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“…The activities of mitochondrial complexes (MitoCom) I∼IV in 5-, 10-, 15-, or 20-day-old Drosophila reared with Nf, GSf, or GSDf were measured as previously published ( 11 , 12 ). Ten Drosophila adults were ground in mitochondria lysis buffer (0.25 M sucrose, 5 mM Tris-HCl, 2 mM EGTA, and 1% BSA, pH 7.4), and then the debris was removed by three layers of medical gauze (Dae Han Medical Supply Co. LTD, Chuncheon-si, South Korea).…”

Section: Methodsmentioning

confidence: 99%

“…Mixed solutions were centrifuged to obtain their supernatants. Following filtration with a syringe filter (0.2 μm pore size, Sartorius AG, Gottingen, Germany) to remove small debris, the amounts of total phenolic compounds and flavonoids were measured as previously published ( 11 , 14 , 36 ). The amounts of phytochemicals in GSD, GSDsup, and GSDprec were normalized by using those of GS.…”

Section: Methodsmentioning

confidence: 99%

“…Therefore, mature silkworms must have various health improvement effects originating from their diverse functional nutrients ( 2 ). In fact, steamed and freeze-dried mature silkworms, also known as HongJam, have been reported to have memory enhancements in mild cognitive impairment rodent models ( 11 , 12 ), preventing the onset of rotenone-induced loss of motor control ( 13 – 15 ), gastrointestinal protection ( 16 , 17 ), liver function improvement ( 18 ), skin whitening ( 19 ), and promotion of the lifespan and healthspan ( 10 , 13 , 14 ).…”

Section: Introductionmentioning

confidence: 99%

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An Alkaline Protease-Digestion of Silkworm Powder Enhances Its Effects Over Healthspan, Autophagy, and Mitochondria Function in a Rotenone-Induced Drosophila Model

Xuan

Kang

et al. 2022

Front. Nutr.

Self Cite

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BackgroundRecent studies have reported that steamed and freeze-dried mature silkworms, also known as HongJam, have various health-promoting effects.ObjectiveThe goal of this study was to elucidate changes in the various health-promoting effects of HongJam, after its digestion with a food-grade protease.Materials and MethodsWe examined whether healthspan-promotion and rotenone-induced loss of motor-control prevention effects were enhanced in Drosophila fed with food-grade alkaline protease-digested HongJam compared to those fed with non-digested HongJam. The differences in mitochondrial functions, chemical susceptibilities, and activations of signal transduction pathways between Drosophila supplemented with various feed were examined to elucidate the molecular and biochemical basis of healthspan-promotion and locomotor-improvement effects of protease-digested HongJam.ResultsWe first found that the healthspan-promotion effect of HongJam digested with a food-grade protease was different depending on the silkworm variety used for its production. Digestion with food-grade protease into White-Jade HongJam (WJ) as prepared from the White-Jade silkworm variety that spins white cocoons did not enhance its functionality. However, compared to Golden-Silk HongJam (GS), a food-grade protease-digested Golden-Silk HongJam (GSD) produced from the Golden-Silk silkworm variety that spins yellow cocoons, it further promoted the healthspan in a Drosophila model. By conducting a series of studies to reveal the molecular and biochemical basis for healthspan-promoting effects, we found that GS and GSD similarly enhanced mitochondrial activity, but GSD activated autophagy signaling more than GS. In addition, GSD feed (GSDf)-, GSD supernatant feed (GSDsupf)-, and GSD precipitate feed (GSDprecf)-reared Drosophila were also found to have increased resistance to an autophagy inhibitor compared to that of normal feed- or GS feed-reared Drosophila. Furthermore, we found that the rotenone-induced loss of motor control prevention effect was superior for GSDsup compared to GS, GSD, or GSDprec. This result may have occurred because GSDsup has more phenolic compounds and antioxidant activities than other samples.ConclusionGSDsup contained more digested small peptides and free phytochemicals than other samples due to the digestion of proteins with a food-grade protease. Thus, GSDsup leads to further healthspan-promoting and locomotor-improvement effects than GS, GSD, or GSDprec.

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“…A recent study by Nguyen et al . (2020a) indicated that steamed and freeze‐dried mature silkworm ( Bombyx mori ) powder (SMSP) reduced oxidative stresses and increased mitochondrial respiratory complex activities and ATM amounts in the brain of mice which resulted in neuron proliferation and scopolamine‐induced amnesia suppression effects. Antioxidant properties of hongjam has been reported (Nguyen et al .…”

Section: Introductionmentioning

confidence: 99%

Future prospects of insects as a biological resource in India: Potential biological products utilizing insects with reference to the frontier countries

Ghosh

Gahukar

Meyer‐Rochow

et al. 2021

Entomological Research

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The semi-organized insect industry of India primarily includes apiculture, sericulture and lac culture. In the last two decades the production of raw silk, including mulberry and "vanya silk", has doubled. An increasing trend for the country has also been observed with regard to honey and beeswax production. India, moreover, stands in the frontline for lac production, but there is immense scope to expand insect-based ventures. For example, sericultural products other than silk come to mind and with regard to apiculture honey, and beeswax need not be the only bee-based commercial items. Insects other than honey bees can be used as food and feed or in the decomposition of waste; some species can be reared and even domesticated as pollinators. In this paper we discuss these unexplored sections, which could open up promising possibilities for the insect-based industry in India as well as other countries.

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Mature silkworm powders ameliorated scopolamine-induced amnesia by enhancing mitochondrial functions in the brains of mice

Cited by 14 publications

References 38 publications

Chemical Composition, Nutrient Quality and Acceptability of Edible Insects Are Affected by Species, Developmental Stage, Gender, Diet, and Processing Method

Chemical Composition, Nutrient Quality and Acceptability of Edible Insects Are Affected by Species, Developmental Stage, Gender, Diet, and Processing Method

An Alkaline Protease-Digestion of Silkworm Powder Enhances Its Effects Over Healthspan, Autophagy, and Mitochondria Function in a Rotenone-Induced Drosophila Model

Future prospects of insects as a biological resource in India: Potential biological products utilizing insects with reference to the frontier countries

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