Mature T-cell and NK-cell lymphoma involvement of the central nervous system: a single center experience

The CNS relapse in T-cell lymphoma index predicts CNS relapse in patients with T- and NK-cell lymphomas

“…Previous retrospective studies report secondary CNS involvement in ∼2% to 11% of patients. 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 In these small series of <30 patients, CNS relapse/progression typically occurred within 6 months of MTNKN diagnosis and was associated with a median OS under 3 months from the time of CNS involvement. 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 Certain histologic subtypes, such as extranodal NK/T-cell lymphomas (ENKTL) and adult T-cell leukemia/lymphoma (ATLL), have a well-described risk of CNS involvement, but the incidence of these diseases varies geographically, and they are excluded from many of these retrospective studies.…”

“…Several other retrospective studies corroborated the increased CNS relapse risk with the involvement of ≥2 extranodal sites. 14 , 15 , 16 , 19 , 22 , 23 Other factors associated with tumor bulk (LDH, 12 IPI score, 14 , 19 and B symptoms 16 ) and anatomic sites of extranodal involvement (paranasal sinus 12 and testicles 16 ) have also been reported as risk factors for CNS involvement in single retrospective studies. The CITI model expands upon these data by creating a comprehensive and dynamic score to personalize CNS relapse risk assessment for patients with MTNKN.…”