Maturin acetate from Psacalium peltatum (Kunth) Cass. (Asteraceae) induces immunostimulatory effects in vitro and in vivo

Juárez-Vázquez, María del Carmen; Alonso-Castro, Ángel Josabad; Rojano-Vilchis, Nadia; Manuel, José; García‐Carrancá, Alejandro

doi:10.1016/j.tiv.2013.01.021

Cited by 6 publications

(3 citation statements)

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“…In the same way, maturin acetate, a naturally occurring compound of “matarique” ( P. peltatum ), also stable under our experimental conditions, displayed an activity similar to that of cacalol acetate. This low activity was probably due to the fact that the acetyl group in both compounds conferred more stability to these molecules, which prevents them from accepting unpaired electrons from ROS [14,22]. Finally, although cacalone has been described as a more potent anti-oxidant and anti-inflammatory compound than even cacalol in the in vivo model of skin inflammation induced by TPA [12], this compound displayed poor anti-inflammatory activity in mast cells.…”

Section: Discussionmentioning

confidence: 99%

“…Few studies have shown the potential effects of maturine acetate in the inflammatory process; maturine acetate reduces the production of pro-inflammatory cytokines (TNF-α and IL-1β) by lypopolysaccharide (LPS)-activated peritoneal macrophages. Maturine acetate also stimulates the proliferation of murine macrophages and splenocytes, induces lysosomal enzyme activity, pinocytosis and NK cell activity, as well as increases the release of IL-2, IL-15 and IFN-γ in immunosuppressed mice, showing relevant immunostimulatory activities [13,14].…”

Section: Introductionmentioning

confidence: 99%

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Chemoinformatic Analysis of Selected Cacalolides from Psacalium decompositum (A. Gray) H. Rob. & Brettell and Psacalium peltatum (Kunth) Cass. and Their Effects on FcεRI-Dependent Degranulation in Mast Cells

et al. 2018

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Cacalolides are a kind of sesquiterpenoids natural compounds synthesized by Psacalium decompositum (A. Gray) H. Rob. & Brettell or Psacalium peltatum (Kunth) Cass. Antioxidant and hypoglycemic effects have been found for cacalolides such as cacalol, cacalone or maturine, however, their effects on inflammatory processes are still largely unclear. The main aim of this study was to investigate the biological activities of secondary metabolites from P. decompositum and P. peltatum through two approaches: (1) chemoinformatic and toxicoinformatic analysis based on ethnopharmacologic background; and (2) the evaluation of their potential anti-inflammatory/anti-allergic effects in bone marrow-derived mast cells by IgE/antigen complexes. The bioinformatics properties of the compounds: cacalol; cacalone; cacalol acetate and maturin acetate were evaluated through Osiris DataWarrior software and Molinspiration and PROTOX server. In vitro studies were performed to test the ability of these four compounds to inhibit antigen-dependent degranulation and intracellular calcium mobilization, as well as the production of reactive oxygen species in bone marrow-derived mast cells. Our findings showed that cacalol displayed better bioinformatics properties, also exhibited a potent inhibitory activity on IgE/antigen-dependent degranulation and significantly reduced the intracellular calcium mobilization on mast cells. These data suggested that cacalol could reduce the negative effects of the mast cell-dependent inflammatory process.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chemoinformatic Analysis of Selected Cacalolides from Psacalium decompositum (A. Gray) H. Rob. & Brettell and Psacalium peltatum (Kunth) Cass. and Their Effects on FcεRI-Dependent Degranulation in Mast Cells

et al. 2018

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“…Maturin asetat menghambat pelepasan sitokin IL-2, IL-15 dan IFN-c jika dibandingkan dengan tikus yang diberikan siklofosfamid, sehingga dapat dijadikan sebagai pemulihan sistem imun pada penyakit yang disebabkan imunosupresi. 27 4.12. Tanacetum parthenium (L.) Sch.Bip.…”

Section: Echinacea Purpurea (L) Moenchunclassified

Artikel Review: Aktivitas Imunomodulator Tanaman dari Suku Asteraceae

Mei

Iskandar²

2022

ijbp

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Imunitas merupakan suatu reaksi pertahanan tubuh terhadap bahan asing, terdapat suatu kondisi dimana sistem imun dapat terganggu sehingga menyebabkan penyakit seperti autoimun, alergi, dan imunodefisiensi. Saat ini terdapat obat sintetik yang dapat mengobati kelainan imun, tetapi obat sintesik memiliki efek samping. Sehingga diperlukan pengobatan alternatif yang penggunaannya dinilai lebih aman. Asteraceae merupakan suku tumbuhan terbesar kedua dalam kingdom Plantae yang tersebar luas di seluruh dunia. Penulisan artikel ini bertujuan untuk memberikan informasi ilmiah beberapa tanaman dari suku Asteraceae yang memiliki aktivitas imunomodulator. Metode yang digunakan dengan cara pencarian pada aplikasi Google Chrome secara daring yang berasal dari Google Scholar, PubMed, ResearchGate, situs jurnal lain. Terdapat beberapa tanaman suku Asteraceae yang memiliki aktivitas imunomodulator diantaranya Ageratum Conyzoides (L.); Artemisia annua L.; Artemisia argyi H. Lev. & Vaniot; Baccharis dracunculifolia DC.; Chromolaena odorata (Lf.) King & Robinson; Cichorium intybus L.; Cynara scolymus L.; Echinacea laevigata (C. L. Boynt. & Beadle) S.F. Blake; Echinacea purpurea (L.) Moench; Echinacea purpurea (L.) Moench; Erigeron floribundus (Kunth) Sch.Bip.; Psacalium peltatum (Kunth) Cass.; Tanacetum parthenium (L.) Sch.Bip.; Tridax procumbens L.Kata kunci: Asteraceae, Imunomodulator, Sistem imun

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Hypoglycemic and anti-inflammatory effects of Psacalium paucicapitatum corms infusions

Rodríguez

García-Hernández

Rocha‐Guzmán

et al. 2017

Industrial Crops and Products

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Maturin acetate from Psacalium peltatum (Kunth) Cass. (Asteraceae) induces immunostimulatory effects in vitro and in vivo

Cited by 6 publications

References 24 publications

Chemoinformatic Analysis of Selected Cacalolides from Psacalium decompositum (A. Gray) H. Rob. & Brettell and Psacalium peltatum (Kunth) Cass. and Their Effects on FcεRI-Dependent Degranulation in Mast Cells

Chemoinformatic Analysis of Selected Cacalolides from Psacalium decompositum (A. Gray) H. Rob. & Brettell and Psacalium peltatum (Kunth) Cass. and Their Effects on FcεRI-Dependent Degranulation in Mast Cells

Artikel Review: Aktivitas Imunomodulator Tanaman dari Suku Asteraceae

Hypoglycemic and anti-inflammatory effects of Psacalium paucicapitatum corms infusions

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