The label "critical neuroscience" captures an important-and, we believe, productive-tension. This tension represents the need to respond to the impressive and at times troublesome surge of the neurosciences, without either celebrating it uncritically or condemning it wholesale. "Critical" alludes, on the one hand, to the notion of "crisis," understood-in the classical Greek, predominantly medical sense of the term-as an important juncture and point of intervention, and, relatedly, to a task similar to that proposed by Kant (1992) in The Conflict of the Faculties (rather than in his more famous "Critiques"), where he defends a space of unconstrained inquiry into the continual pressures put on scientific knowing by the vagaries of the political sphere. This opens up a space for inquiry that is itself inherently and self-consciously political. On the other hand, the concept of "critique" raises important associations with Frankfurt School critical theory. While critical neuroscience does not directly follow a Frankfurt School program, nor the reduction of science to positivism espoused by early critical theory, it does share with it a spirit of historico-political mission; that is, the persuasion that scientific inquiry into human reality tends to mobilize specific values and often works in the service of interests that can easily shape construals of nature or naturalness. These notions of nature or of what counts as natural, whether referring to constructs of gender, mental disorder, or normal brain development, require unpacking. Without critical reflection, they appear as inevitable givens, universal and below history, and are often seen as a form of "normative facticity," making specific claims upon us in everyday life (see Hartmann, this volume). In this chapter, we will spell out how our proposal for a critical neuroscience is not motivated by the aim to undermine the epistemological validity of neuroscience or debunk its motives, nor is it simply an opportunity to establish yet another neuroprefixed discipline. Situated between neuroscience and the human sciences, our notion of critical neuroscience uses a historical sensibility to analyze the claim that we