Maxillary calcifying epithelial odontogenic tumor

Case report and review of calcifying epithelial odontogenic tumor

“…CEOT named "Pindborg tumor" is a rare benign neoplasm making up <1% of all odontogenic tumors. 5 This tumor was also known by different names, such as ameloblastoma of unusual type with calcification, calcifying ameloblastoma, malignant odontoma, adenoid adamantoblastoma, cystic complex odontoma and as a variant of the simple ameloblastoma. 6 CEOT were all associated with an unerupted tooth, Pindborg was initially of the opinion, that the CEOT was indeed of odontogenic origin, and second that the tumour develops from the reduced enamel organ of the unerupted tooth.…”

“…Amyloid-like matrix is a unique component that may be associated with tumor maturation and differentiation, and possibly lower risk of malignant transformation. [3][4][5][6][7][8][9] Our first case represented a classical CEOT picture with sheets of epithelial cells, amyloid matrix and round calcified material.…”

“…2 Variants of CEOT include clear cell, myoepithelial cell, pigmented, Langerhans cell containing, bone and cementum forming, and cystic and noncalcifying. 5 1994 Hicks et al suggested that the presence of clear cells in CEOT may be associated with more aggressive behavior. 11 Anderson et al interpreted the clear cells as representing a degenerative process, Yamaguchi et al were of the opinion that the clear tumour cells represent a feature of cytodifferentiation rather than that of a simple degenerative phenomenon.…”

“…Overall prognosis seems to be good, though there is a report of malignant transformation and metastasis. 5…”