Maxillary rhinosinusitis due to Fusarium species leading to cavernous sinus thrombosis

Rajmane, Vijaya; Rajmane, Shivkumar T.; Patil, Virendra C.; Patil, Aishwarya; Mohite, Shivajirao T

doi:10.1016/j.mycmed.2012.12.001

Cited by 5 publications

(4 citation statements)

References 9 publications

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“…346 Invasive disease or dissemination is exceptionally rare in immunocompetent hosts. 343,347 However, in patients with severe immune deficits, disseminated fusariosis can affect virtually any organ (e.g., lung, 331,335 sinuses, 348,349 bone, 350,351 joints, 352 endophthalmitis, 353 brain, 320 aorta, 354 and heart 339,[354][355][356] ). In disseminated fusariosis, lung involvement occurs in approximately 50%.…”

Section: Clinical Features Of Fusariosismentioning

confidence: 99%

Fungal Infections Complicating Lung Transplantation

Clark

Weigt

Fishbein³

et al. 2018

Semin Respir Crit Care Med

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Lung transplantation is an increasingly utilized modality for treating advanced lung disease. However, lung transplant recipients (LTRs) experience high rates of infection-related mortality and, compared with other solid organ transplant recipients, are at increased risk of infectious complications given the intensity of immunosuppression employed, the presence of airway abnormalities after surgery and exposure of the allograft to the environment. Fungal infections, particularly mold infections, are problematic after transplantation as they are often associated with limited treatment options and poor outcomes. We describe the non- fungal infections occurring in LTRs, including their epidemiology, clinical features, and treatment.

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Section: Clinical Features Of Fusariosismentioning

confidence: 99%

Fungal Infections Complicating Lung Transplantation

Clark

Weigt

Fishbein³

et al. 2018

Semin Respir Crit Care Med

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“…12,13 Indeed, Fusarium is the leading etiologic agent of fungal keratitis. In addition, various infections caused by Fusarium species in immunocompetent patients have been reported, including combat-related injuries, 14 peritonitis in patients receiving peritoneal dialysis, 15,16 thrombophlebitis, 17 arthritis, 18,19 osteomyelitis, [20][21][22][23] endophtalmitis, 24 fungemia, [25][26][27] sinusitis, [28][29][30][31] and pneumonia. [32][33][34] Fusariosis in immunocompromised patients is almost always an invasive and frequently disseminated disease.…”

Section: Clinical Spectrum Of Fusariosismentioning

confidence: 99%

“…The clinical spectrum of lung disease associated with Fusarium species is similar to that caused by Aspergillus species and includes allergic disease (allergic bronchopulmonary fusariosis), 59 hypersensitivity pneumonitis, 29 colonization of a pre-existing cavity, 60 localized pneumonia in immunocompetent individuals, 61 and pneumonia in severely immunocompromised patients. 3,8 We did a literature review of 294 cases of fusariosis, 3 and updated with 63 additional cases in immunocompetent 19,25,27,[61][62][63][64][65][66][67] and immunocompromised patients 31,34,39,43,44,47,48,50, published between 2005 and 2014. Pneumonia caused by Fusarium species was reported in 152 cases (42%), occurring in 145 of 317 (46%) immunocompromised patients and in seven of 40 (17.5%) immunocompetent patients (p < 0.001).…”

Section: Fusariosis In the Lungsmentioning

confidence: 99%

Fusariosis

Nucci

Nouér

Capone

et al. 2015

Semin Respir Crit Care Med

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Fusarium species are frequent agents of onychomycosis and fungal keratitis, and occasional agents of invasive disease. The clinical spectrum of fusariosis in the lungs includes allergic disease (allergic bronchopulmonary fusariosis), hypersensitivity pneumonitis, colonization of a preexisting cavity, and pneumonia. Fusarial pneumonia occurs almost exclusively in severely immunocompromised patients, especially acute leukemia patients and recipients of allogeneic cell transplantation. In such patients, invasive fusariosis is usually disseminated, and pneumonia occurs in almost 50% of cases. The radiologic picture is similar to invasive aspergillosis, with alveolar infiltrates, nodules with or without halo sign, ground-glass infiltrates, and pleural effusions. Different from aspergillosis is the frequent occurrence of disseminated nodular and papular skin lesions and positive blood cultures. The drug of choice for the treatment of invasive fusariosis is either voriconazole or liposomal amphotericin B. The outcome is usually poor, and largely dependent on the recovery of the immune status of the host, particularly neutropenia.

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“…13 Reports of Fusarium infections are usually resulting from tissue breakdown or trauma. Infections are mostly localized to involve the cornea, [14][15][16] skin and nail, 17,18 cellulitis after injury, 19,20 sinusitis, [21][22][23][24] and pneumonia. 25,26 Fusarium osteomyelitis was also reported in multiple case reports, mostly in immunocompromised and type 2 diabetic patients.…”

Section: Discussionmentioning

confidence: 99%

Fusarium-Induced Cellulitis in an Immunocompetent Patient With Sickle Cell Disease: A Case Report

Samrah

Sweidan

Aleshawi

et al. 2020

Journal of Investigative Medicine High Impact Case Reports

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Fungal infections due to Fusarium species are mostly present in immunocompromised and patients with poorly controlled diabetes mellitus. We report a case of lower extremity skin infection caused by Fusarium species in a 61-year-old woman diagnosed with sickle cell disease. Single skin ulceration caused by Fusarium species can result from fungal inoculation into damaged tissue, so any condition that damages the skin can be considered as a risk factor for inoculation. Long-standing sickle cell disease may develop vaso-occlusion in the skin that can produce lower extremity ulcers and myofascial syndromes. The mechanism is not completely characterized, but compromised blood flow, endothelial dysfunction, thrombosis, inflammation, and delayed healing are thought to contribute to locally compromised tissue that may eventually lead to opportunistic infection such as in our case. Other factors contribute to the pathophysiology of lower extremity ulcers such as diabetes mellitus, with the resulting peripheral vascular ischemia causing poor circulation to the lower extremity, and peripheral neuropathy, which can make patients with diabetes unaware of minor trauma leading to the development of skin infections.

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Maxillary rhinosinusitis due to Fusarium species leading to cavernous sinus thrombosis

Cited by 5 publications

References 9 publications

Fungal Infections Complicating Lung Transplantation

Fungal Infections Complicating Lung Transplantation

Fusariosis

Fusarium-Induced Cellulitis in an Immunocompetent Patient With Sickle Cell Disease: A Case Report

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