Maxillary sinus augmentation: Histomorphometric analysis of graft materials for maxillary sinus floor augmentation

Moy, Peter K.; Lundgren, Stefan; Holmes, Ralph E.

doi:10.1016/s0278-2391(10)80103-x

Cited by 239 publications

(170 citation statements)

References 11 publications

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“…Many researchers in the field have suggested investigating potential alternatives to bone graft as a treatment for the reconstruction of cleft palate (Lohberger et al, 2013). Moy, Lundgren, and Holmes (1993) found that bone graft substitute materials implanted alone instead of autologous bone graft resulted in a lower success rate compared with the combination of cells and bone graft substitute. This suggests that tissue engineering strategies using cells combined with a supportive biomaterial scaffold may be a more effective treatment for cleft palate repair than biomaterials alone (Behnia, Khojasteh, Soleimani, Tehranchi, & Atashi, 2012; Khojasteh, Eslaminejad, & Nazarian, 2008).…”

Section: Introductionmentioning

confidence: 99%

A simple rocker‐induced mechanical stimulus upregulates mineralization by human osteoprogenitor cells in fibrous scaffolds

Puwanun

Delaine-Smith

Colley

et al. 2017

J Tissue Eng Regen Med

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Biodegradable electrospun polycaprolactone scaffolds can be used to support bone‐forming cells and could fill a thin bony defect, such as in cleft palate. Oscillatory fluid flow has been shown to stimulate bone production in human progenitor cells in monolayer culture. The aim of this study was to examine whether bone matrix production by primary human mesenchymal stem cells from bone marrow or jaw periosteal tissue could be stimulated using oscillatory fluid flow supplied by a standard see‐saw rocker. This was investigated for cells in two‐dimensional culture and within electrospun polycaprolactone scaffolds. From day 4 of culture onwards, samples were rocked at 45 cycles/min for 1 h/day, 5 days/week (rocking group). Cell viability, calcium deposition, collagen production, alkaline phosphatase activity and vascular endothelial growth factor secretion were evaluated to assess the ability of the cells to undergo bone differentiation and induce vascularisation. Both cell types produced more mineralized tissue when subjected to rocking and supplemented with dexamethasone. Mesenchymal progenitors and primary human mesenchymal stem cells from bone marrow in three‐dimensional scaffolds upregulated mineral deposition after rocking culture as assessed by micro‐computed tomography and alizarin red staining. Interestingly, vascular endothelial growth factor secretion, which has previously been shown to be mechanically sensitive, was not altered by rocking in this system and was inhibited by dexamethasone. Rocker culture may be a cost effective, simple pretreatment for bone tissue engineering for small defects such as cleft palate.

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Section: Introductionmentioning

confidence: 99%

A simple rocker‐induced mechanical stimulus upregulates mineralization by human osteoprogenitor cells in fibrous scaffolds

Puwanun

Delaine-Smith

Colley

et al. 2017

J Tissue Eng Regen Med

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“…HA when used with DFDBA as opposed to their single use also showed good results as a synergistic effect of osteoinduction and osteoinduction was observed [24][25][26].…”

Section: Discussionmentioning

confidence: 96%

A Comparative Evaluation of Decalcified Freeze Dried Bone Allograft, Hydroxyapatite and Their Combination in Osseous Defects of the Jaws

Mishra

Singh

Mohammad

et al. 2010

J. Maxillofac. Oral Surg.

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Objectives To evaluate decalcified freeze dried allograft or hydroxyapatite and a combination of both as bone autograft substitutes in the healing of osseous jaw defects. Materials and Methods 24 patients participated in the study which involved the filling of osseous defects in the maxilla/mandible with decalcified freeze dried bone allograft (DFDBA) or hydroxyapatite (HA) or a combined graft composed of these two in equal proportions. Results Bone formation occurred as early as 4 weeks in the DFDBA and combination groups and 12 weeks in the HA group which was verified by radiographs, Dentascans (DentaScanÒ Software Program, General Electric, USA) and bone scintigraphy. Conclusion Both these materials can be used as bone graft substitutes in smaller defects although their suitability in large defects is yet to be studied.

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“…Utilization of autogenous bone is justified by the fact that this material has a high osteogenic potential in comparison with other types of materials. In addition, it has cells with bone induction capacity and does not produce immunological reaction 17 .…”

Section: Discussionmentioning

confidence: 99%

Viability of autogenous bone grafts obtained by using bone collectors: histological and microbiological study

Blay

Tunchel

Sendyk

2003

Pesqui. Odontol. Bras.

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ABSTRACT:The use of autogenous bone grafts is considered to be the best choice for reconstructive surgery. In the periodontal literature, the utilization of osseous coagulum was suggested by the end of the sixties. The purpose of this study is to consider the use of bone collectors (bone traps) as an alternative method for obtaining material to fill small bone imperfections, such as fenestrations and dehiscences. Thirty samples were obtained from bone drilling during fixture installation in patients (13 men and 17 women, with an average age of 54 years) requiring treatment at the Department of Periodontology and Implant Dentistry, University of Santo Amaro. These samples were fixed in 10% neutral formaldehyde for 24 hours and subjected to histological preparation, in order to evaluate the presence of viable osteoblasts. In addition, the material was placed in a fluid thioglycolate medium and incubated for 24 hours at 36 ± 1°C in aerobiosis and anaerobiosis. Bacterial growth evaluation was made by using six different culture media (MacConkey agar, blood agar base, mannitol salt agar, Anaerokit LTD medium, Anaerokit LTD -bile medium, Anaerinsol). The results show that, if proper care is taken to prevent saliva contamination during the surgical procedure, this method of collecting autogenous bone may be useful in situations where small amounts of bone are required. DESCRIPTORS: Dental implantation; Bone transplantation; Bone regeneration. RESUMO:A utilização de enxertos autógenos é considerada a melhor opção nos tratamentos cirúrgicos de reconstrução óssea. Na literatura periodontal, a utilização de coágulo ósseo foi sugerida no final da década de 60. O objetivo deste estudo é considerar a utilização de coletores para osso como um método alternativo de se obter osso autógeno para preenchimento de defeitos ósseos como fenestrações e deiscências. Trinta amostras foram obtidas no processo de perfuração do tecido ósseo, durante a instalação de implantes em pacientes (13 homens e 17 mulheres, com média etária de 54 anos) que foram submetidos a tratamento na Disciplina de Periodontia e Implantodontia da Universidade de Santo Amaro. Essas amostras foram fixadas em solução de formol neutro a 10% por 24 horas para serem analisadas histologicamente com o intuito de avaliar a presença de osteoblastos viáveis. Além das amostras fixadas, também foram obtidos espécimens que foram incubados em aerobiose e em anaerobiose, em meio de tioglicolato por 24 h a 36 ± 1°C. A avaliação do crescimento bacteriano foi feita através de seis meios seletivos de cultura (ágar MacConkey, ágar-sangue, ágar manitol, meio Anaerokit LTD, meio Anaerokit LTD -bile e Anaerinsol). Os resultados mostraram que, se forem tomados certos cuidados para prevenir a contaminação com saliva durante o procedimento cirúrgico, este método de coletar osso autógeno pode ser útil em situações em que pequenas quantidades de osso são necessá-rias.

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Maxillary sinus augmentation: Histomorphometric analysis of graft materials for maxillary sinus floor augmentation

Cited by 239 publications

References 11 publications

A simple rocker‐induced mechanical stimulus upregulates mineralization by human osteoprogenitor cells in fibrous scaffolds

A simple rocker‐induced mechanical stimulus upregulates mineralization by human osteoprogenitor cells in fibrous scaffolds

A Comparative Evaluation of Decalcified Freeze Dried Bone Allograft, Hydroxyapatite and Their Combination in Osseous Defects of the Jaws

Viability of autogenous bone grafts obtained by using bone collectors: histological and microbiological study

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