Maxillary sinus marrow hyperplasia in sickle cell anemia

Fernández, M. Soledad Sánchez; Slovis, T. L.; Whitten-Shurney, Wanda

doi:10.1007/bf03545633

Cited by 18 publications

(4 citation statements)

References 2 publications

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“…After reviewing the literature, common themes were identified in the detection and diagnosis of EMH (Table 1). 2,[5][6][7][8][9][10][11][12][13][14][15][16][17] On CT imaging, the hematopoietic tissue typically appears as a soft tissue mass that may demonstrate calcifications. Several cases involving the paranasal sinuses showed bone remodeling, bulging, and protrusion into other sinuses.…”

Section: Resultsmentioning

confidence: 99%

Extramedullary Hematopoiesis in the Sinonasal Cavity: A Case Report and Review of the Literature

Worden

Thorp

et al. 2020

Allergy�Rhinol (Providence)

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Background Extramedullary hematopoiesis (EMH) occurs in patients with hematologic disorders, but rarely within the paranasal sinuses. We report a case of EMH in a 17-year-old male with sickle cell disease (SCD) who presented with occipital pain and sinusitis. A computed tomography (CT) scan demonstrated heterogeneous opacification of the right maxillary sinus concerning for allergic fungal sinusitis or a fungal ball with bony erosion. He was taken to the operating room for endoscopic biopsy and a limited endoscopic sinus surgery. Grossly, his maxillary sinus was filled with spiculated osseous tissue. Final pathology demonstrated active hematopoietic bone marrow filling the sinus. Methods We present a case report and literature review of sinonasal EMH. Results We identified 14 articles with 15 patients. EMH was typically associated with SCD or beta thalassemia. The average age of presentation was 30. There was a male sex predilection with a ratio of 11:15. The most common presenting symptom was a headache and nasal obstruction (33% for both). The most common finding on CT was a soft tissue expansile mass (73%). The most commonly affected location was the maxillary sinus (60%). Conclusions This case report serves as a reminder to consider EMH as an uncommon cause of sinus opacification, particularly in patients with SCD or beta thalassemia. The expansion of hematopoietic tissue may be identified as a sinus mass on CT. By recognizing the potential manifestations of chronic anemia, an accurate and timely diagnosis can be made.

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Section: Resultsmentioning

confidence: 99%

Extramedullary Hematopoiesis in the Sinonasal Cavity: A Case Report and Review of the Literature

Worden

Thorp

et al. 2020

Allergy�Rhinol (Providence)

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show abstract

“…CT imaging revealed characteristic expansile masses involving the bilateral maxillary and ethmoid sinuses. The maxillary sinuses were also involved in 2 other cases, 1 a 28‐month‐old child with sickle cell disease 4 , and another a 24‐year‐old man with beta‐thalassemia 1 ,. The sphenoid sinus has also been identified as a location of extramedullary hematopoiesis in a patient with beta‐thalassemia >1 , and SCD 5 ,.…”

Section: Discussionmentioning

confidence: 99%

Extramedullary hematopoiesis of the paranasal sinuses in sickle cell disease

Collins¹,

Younis²,

Garcia

2005

Otolaryngol.--head neck surg.

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“…A neuropatia do nervo alveolar inferior causa parestesia permanente ou temporária (24 meses) 5 . A neuropatia deste nervo é mais vulnerável devido ao seu trajeto, no estreito canal mandibular 5,8,12,19,21 . A neuropatia do nervo mandibular é mais frequente em indivíduos do sexo feminino, podendo ser unilateral ou bilateral 13 .…”

Section: Introdução|unclassified

“…Consequentemente, há perda das finas e numerosas trabéculas ósseas e a substituição por poucas trabéculas dispostas horizontalmente, resultando na formação de amplos espaços medulares com padrão de um trabeculado ósseo grosseiro 11 . Tanto a maxila como a mandíbula (79%-100%) apresentam diminuição da radiodensidade (osteoporose) 2,5,12,21 . Na maxila, por se tratar de um osso predominantemente medular, as alterações são mais visíveis.…”

Section: Introdução|unclassified