Abstract. The formulas presented in [Molinari, L.G. Determinants of block tridiagonal matrices. Linear Algebra Appl., 2008; 429, 2221-2226 for evaluating the determinant of block tridiagonal matrices with (or without) corners are used to derive the determinant of any multidiagonal matrices with (or without) corners with some specified non-zero minors. Algorithms for calculation the determinant based on this method are given and properties of the determinants are studied. Some applications are presented.