Maximal pericoronary adipose tissue thickness is associated with hypertension in nonobese patients with acute or chronic illness

Abstract

Background/AimsRecent studies have shown an association of epicardial fat thickness with diabetes and hypertension (HTN) in asymptomatic populations. However, there is lack of information as to whether there is similar association between pericoronary adipose tissue (PAT) and HTN in the patients who have acute or chronic illness.MethodsThis study included 214 nonobese patients hospitalized with acute or chronic noncardiogenic illness. PAT thicknesses were measured from fat tissues surrounding left and right coronary arteries in enhanced, chest computed tomography scans, yielding the maximal PAT value from left and right coronary arteries was used for analysis. Baseline data from hypertensive (n = 81) and normotensive (n = 133) patients were collected and compared.ResultsPAT is positively correlated with age (r = 0.377, p <0.001), body mass index (BMI; r = 0.305, p < 0.001), systolic blood pressure (r = 0.216, p = 0.001), and total cholesterol (r = 0.200, p = 0.006). The hypertensive group was older (69.58 ± 11.69 years vs. 60.29 ± 14.98 years), and had higher PAT content (16.30 ± 5.37 mm vs. 13.06 ± 5.58 mm) and BMI (23.14 ± 3.32 kg/m2 vs. 20.96 ± 3.28 kg/m) than the normotensive group (all p < 0.001). Multivariate analysis showed that age (odds ratio [OR], 2.193; p = 0.016), PAT thickness (OR, 1.065; p = 0.041), and BMI (25 ≤ BMI < 30 kg/m2 ; OR, 6.077; p = 0.001) were independent risk factors for HTN.ConclusionsIn nonobese patients with noncardiogenic acute or chronic illness, PAT thickness is independently correlated with HTN, age, and BMI.

Epicardial Adipose Tissue Accumulation and Essential Hypertension in Non-Obese Adults

“…Some previous studies conducted by other authors confirm the increase in size of EAT depots among the patients with EH [18,19,31,32,33,34,35]. The difference between our study and the majority of previous studies is that along with EAT thickness measurements we have also measured EAT volume.…”

“…Along with EH occurrence disparities, diverging results regarding the correlation between the size of EAT depots and blood pressure are presented in the literature [19,26]. We have found no studies where EAT depots would be assessed with respect to the grade of hypertension that describes the state of a patient more accurately than momentary blood pressure measurements.…”

“…On the other hand, determination of real hypertensive patients remains a clinical problem, and finding the imaging technique to distinguish hypertensive patients from those with normal blood pressure would be beneficial [18]. Few studies were performed in order to investigate the association between hypertension and the size of EAT depots, but different methods and diverging results do not provide clear evidence for such an association [13,14,18,19,20,21,22,23,24,25,26,27,28]. In addition to this, some studies indicate the association between the size of EAT depots and severity of hypertension [21,25,29].…”

Epicardial Adipose Tissue: A Piece of The Puzzle in Pediatric Hypertension

“…Many studies agree that the amount of EAT is higher in hypertensive adult patients [ 16 , 26 , 27 , 28 , 29 ]. There are fewer studies which propose this link in children and adolescents [ 19 ].…”

Environmental Tobacco Smoke Exposure Estimated Using the SHSES Scale and Epicardial Adipose Tissue Thickness in Hypertensive Patients

“…In a study by Özdil et al EAT thickness measured by echocardiography was an independent predictor of new diagnosis of hypertension [ 34 ]. Chang et al performed a study on 214 non-obese patients hospitalized with acute or chronic non-cardiogenic illness and found that EAT thickness was independently correlated with hypertension, age, and BMI [ 35 ]. Moreover, in another study on 80 patients who were diagnosed with hypertension EAT thickness showed a significant correlation with 24-h SBP ( r = 0.434, p < 0.001) [ 36 ].…”