Maximal Voluntary Ventilation Should Not Be Estimated From the Forced Expiratory Volume in the First Second in Healthy People and COPD Patients

Abstract

Purpose: To evaluate the concordance between the value of the actual maximum voluntary ventilation (MVV) and the estimated value by multiplying the forced expiratory volume in the first second (FEV 1 ) and a different value established in the literature.Methods: A retrospective study was conducted with healthy subjects and patients with stable chronic obstructive pulmonary disease (COPD). Five prediction formulas MVV were used for the comparison with the MVV values. Agreement between MVV measured and MVV obtained from five prediction equations were studied. FEV 1 values were used to estimate MVV. Correlation and agreement analysis of the values was performed in two groups using the Pearson test and the Bland-Altman method; these groups were one group with 207 healthy subjects and the second group with 83 patients diagnosed with COPD, respectively.Results: We recruited 207 healthy subjects (105 women, age 47 ± 17 years) and 83 COPD patients (age 66 ± 6 years; 29 GOLD II, 30 GOLD III, and 24 GOLD IV) for the study. All prediction equations presented a significant correlation with the MVV value (from 0.38 to 0.86, p < 0.05) except for the GOLD II subgroup, which had a poor agreement with measured MVV. In healthy subjects, the mean difference of the value of bias (and limits of agreement) varied between -3.9% (-32.8 to 24.9%), and 27% (-1.4 to 55.3%). In COPD patients, the mean difference of value of bias (and limits of agreement) varied between -4.4% (-49.4 to 40.6%), and 26.3% (-18.3 to 70.9%). The results were similar in the subgroup analysis.

Calculated Maximal Volume Ventilation (cMVV) as a Marker of Early Respiratory Failure in Amyotrophic Lateral Sclerosis (ALS)

“…In many papers on the differences between measured MVV (mMVV) and calculated MVV (cMVV), which is obtained by multiplying the MVV with measured FEV1, a standardized and reproducible maneuver, with an appropriate factor (generally 35 or 40), has been observed to be significant [16,17,19,[21][22][23]37]. Preferences regarding the use of cMVV versus mMVV for ventilator capacity calculation are dependent on the studied cohort: for example, in pediatric populations, cMVV has been shown to be a more accurate surrogate measure of maximum ventilator capacity, most likely due to inadequate effort and inability to perform MVV maneuvers [38].…”

Inspiratory muscle training in patients with obesity: a systematic review and meta-analysis

“…On the other hand, only one study evaluated maximal voluntary ventilation (MVV) and showed improvement suggesting that this intervention could be effective for this outcome ( 30 ). Although this test measures ventilation, it has been described in the literature as an assessment scale for the endurance of respiratory muscles ( 45 ).…”

Effect of different conditioning methods of traditional Chinese health exercise on lung function in healthy middle-aged and elderly people: study protocol for a randomized controlled trial

“…MVV is the ventilation volume obtained by repeating the maximum spontaneous breathing as fast and as deep as possible in a period of time and is a reliable index for the comprehensive evaluation of the pulmonary ventilation reserve [ 39 , 45 ]. It is related to the strength of the respiratory muscles, the elasticity of the thorax and lung tissue, and airway resistance.…”