“…For most of the century and a half since Maxwell first proposed the thought experiment an entity that could sort molecules on the molecular scale was beyond the reach of technology, and Maxwell’s demon stood primarily as an abstract conceptual tool for understanding the statistical foundations of thermodynamics. In recent years, though, advances in nanotechnology have brought molecular machines into the realm of possibility, and devices approximating the function of Maxwell’s demon have now been made [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ]. Biochemical analogs of Maxwell’s demon are under development for molecular synthesis [ 31 , 32 ].…”