Maximizing the strength of calcium sulfate for structural bone grafts

Cavelier, Sacha; Tänzer, Michael; Barthelat, François

doi:10.1002/jbm.a.36873

Cited by 11 publications

(9 citation statements)

References 28 publications

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“…The mechanical properties of gypsum cements are mainly measured in compression, and most of the reported values were measured in dry conditions, which do not represent the humid body environment . In this study, adding the l -enantiomer of tartaric acid increased the compressive strength of gypsum cements by about 40%, reaching a maximum compressive strength of 65 MPa.…”

Section: Resultsmentioning

confidence: 65%

“…The hemihydrates have two modifications, α and β. The β-phase is produced when the dehydration proceeds under dry condition, while the α-phase is formed by autoclaved heating. , Gypsum cement is synthetically made from calcium sulfate hemihydrate according to the following equation When CaSO 4 · H 2 O powder is combined with water, it forms a slurry in which gypsum crystals grow and interlock, resulting in a solid gypsum structure. The phase of CaSO 4 · H 2 O (α or β) determines the mechanical properties of the resulting gypsum cements.…”

Section: Introductionmentioning

confidence: 99%

“…The β-phase is produced when the dehydration proceeds under dry condition, while the α-phase is formed by autoclaved heating. 13,14 Gypsum cement is synthetically made from calcium sulfate hemihydrate according to the following equation 14 CaSO determines the mechanical properties of the resulting gypsum cements. The β-phase forms irregular crystals that yield mechanically weak gypsum cements with very fast resorption rates.…”

Section: Introductionmentioning

confidence: 99%

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Selective Crystal Growth Regulation by Chiral α-Hydroxycarboxylic Acids Improves the Strength and Toughness of Calcium Sulfate Cements

Moussa

Jiang

hadad

et al. 2020

ACS Appl. Bio Mater.

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Natural biominerals, such as bones and teeth, use acidic matrix biomolecules to control growth, morphology, and organization of the brittle hydroxyapatite crystals. This interplay provides biominerals with outstanding mechanical properties. Recently, we reported that the l-enantiomer of chiral tartaric acid has a potent regulatory effect on the crystal structure and mechanical performance of brushite cement, a mineral with a monoclinic crystal system. We hypothesized that this strategy could be applied using various chiral α-hydroxycarboxylic acids to enhance the mechanical performance of calcium sulfate dihydrate cements, another mineral belonging to the monoclinic crystal system. Calcium sulfate cements are widely used in dentistry, medicine, and construction, but these cements have low mechanical properties. In this work, we first determined the impact of different chiral α-hydroxycarboxylic acids on the properties of calcium sulfate cements. After that, we focused on identifying the regulation effect of chiral tartaric acid on gypsum crystals precipitated in a supersaturated solution. Here, we show that the selective effect of α-hydroxycarboxylic acid l-enantiomers on calcium sulfate crystals improved the mechanical performance of gypsum cements, while d-enantiomer had a weak impact. Compare to the calcium sulfate cements prepared without additives, the presence of l-enantiomer enhanced the compressive strength and the fracture toughness of gypsum cements by 40 and 70%, respectively. Thus, these results prove the generalizability of this approach and help us to fabricate high-strength cements.

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Section: Resultsmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Selective Crystal Growth Regulation by Chiral α-Hydroxycarboxylic Acids Improves the Strength and Toughness of Calcium Sulfate Cements

Moussa

Jiang

hadad

et al. 2020

ACS Appl. Bio Mater.

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“…The clinical application of CSH is limited because of its weak strength, fast curing, rapid dissolution, and lack of biological activity ( Cavelier et al, 2020 ; Xu et al, 2020 ). However, calcium sulfate can be applied in clinical practice mainly because its degradation rate and curing time can be delayed by optimizing its crystal phase, and better mechanical properties can be obtained.…”

Section: Discussionmentioning

confidence: 99%

A Composite of Cubic Calcium-Magnesium Sulfate and Bioglass for Bone Repair

Chen

Zhang²,

Zhang³

et al. 2022

Front. Bioeng. Biotechnol.

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Calcium sulfate (CS) bone cement has been shown to have good biocompatibility and can be used as a bone filler for repairing bone defects. However, its clinical application is limited due to its low compressive strength and weak bone repair activity. To this end, in this study, cubic crystalline magnesium-doped calcium sulfate (MgCS) was prepared and mixed with 45S5 bioglass (BG) to form a composite bone cement (MgCS/BG). The results show that cubic crystal calcium sulfate helps to increase the compressive strength of the composite bone cement to more than 60 MPa. More importantly, the obtained magnesium-doped composite bone cement can promote the adhesion and differentiation of mesenchymal stem cells and has good bioactivity. Through a skull defect model, it was found that MgCS/BG can significantly enhance bone defect repair and new bone formation. This new composite MgCS/BG is very promising for future translation into clinical applications.

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“…[ 247 ] Another bone graft material still in use is calcium sulfate because of its remarkable combination of biocompatibility, biodegradability, and osteoconductivity. [ 248 ] Calcium sulfate exists in three different forms; calcium sulfate anhydrate, calcium sulfate hemihydrate, and calcium sulfate dehydrate. The difference between them is the amount of water molecules residing within a molecule unit.…”

Section: Biomaterialsmentioning

confidence: 99%

Recent Advances in Synthetic and Natural Biomaterials‐Based Therapy for Bone Defects

Echazú

Perna

Olivetti

et al. 2022

Macromolecular Bioscience

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Synthetic and natural biomaterials are a promising alternative for the treatment of critical-sized bone defects. Several parameters such as their porosity, surface, and mechanical properties are extensively pointed out as key points to recapitulate the bone microenvironment. Many biomaterials with this pursuit are employed to provide a matrix, which can supply the specific environment and architecture for an adequate bone growth. Nevertheless, some queries remain unanswered. This review discusses the recent advances achieved by some synthetic and natural biomaterials to mimic the native structure of bone and the manufacturing technology applied to obtain biomaterial candidates. The focus of this review is placed in the recent advances in the development of biomaterial-based therapy for bone defects in different types of bone. In this context, this review gives an overview of the potentialities of synthetic and natural biomaterials: polyurethanes, polyesters, hyaluronic acid, collagen, titanium, and silica as successful candidates for the treatment of bone defects.

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Maximizing the strength of calcium sulfate for structural bone grafts

Cited by 11 publications

References 28 publications

Selective Crystal Growth Regulation by Chiral α-Hydroxycarboxylic Acids Improves the Strength and Toughness of Calcium Sulfate Cements

Selective Crystal Growth Regulation by Chiral α-Hydroxycarboxylic Acids Improves the Strength and Toughness of Calcium Sulfate Cements

A Composite of Cubic Calcium-Magnesium Sulfate and Bioglass for Bone Repair

Recent Advances in Synthetic and Natural Biomaterials‐Based Therapy for Bone Defects

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