Maximum human lifespan may increase to 125 years

Beer, Joop de; Bardoutsos, Anastasios; Janssen, Fanny

doi:10.1038/nature22792

Cited by 47 publications

(30 citation statements)

References 6 publications

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“…We estimated the value of this bound for common model organisms and humans. The human bound (~138 years) is higher than that recently reported (Brown et al, 2017;De Beer et al, 2017;Dong et al, 2016b;Hughes and Hekimi, 2017;Rozing et al, 2017) based on the data for the oldest old. It should be noted that our results for the bound are more general, as they follow from a statistical analysis of survival functions of entire cohorts rather than on the analysis of outliers.…”

Section: Discussioncontrasting

confidence: 64%

The landscape of longevity across phylogeny

Podolskiy

Avanesov

Tyshkovskiy

et al. 2020

Preprint

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Lifespan of model organisms can be extended by genetic, dietary and pharmacological interventions, but these effects may be negated by other factors. To understand robustness of longevity interventions within and across species, we analyzed age-dependent mortality of yeast, fruit flies, nematodes and mice subjected to thousands of genetic, pharmacological or dietary interventions, and applied the principles learned to other organisms. Across phylogeny, the accessible space of lifespan distribution functions, the "landscape of longevity", has a distinct structure of a fiber bundle, with individual fibers given by Strehler-Mildvan degeneracy manifolds. Within species, most interventions perturb parameters of survival curves along particular degeneracy manifolds. Transitions across manifolds are difficult to achieve, but they may lead to robust lifespan-modulating effects. Analyses of intraspecific degeneracy manifolds revealed soft bounds on achievable longevity. For humans, this bound is ~138 years.

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Section: Discussioncontrasting

confidence: 64%

The landscape of longevity across phylogeny

Podolskiy

Avanesov

Tyshkovskiy

et al. 2020

Preprint

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“…The heterogeneity in population and the dynamics of heterogeneous populations would become important in interpreting human lifespan [37,38]. The question about whether the upper limit to the maximum lifespan is fixed or flexible has been topics of continuous debate [34,[39][40][41][42][43][44][45]. The decrease of the ω estimate in Figure 4 means that more people can reach the biological lifespan limit as expected to be 125 years [12].…”

Section: Discussionmentioning

confidence: 99%

Stretched Exponential Survival Analysis for South Korean Females

Weon

2019

Applied Sciences

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South Korea has recently exhibited a remarkable rapid increase in female lifespan. Here, a mathematical analysis is suggested for a clear interpretation of current trends in female lifespan in South Korea. To mathematically analyze life tables, a modified stretched exponential function is employed and demonstrated to estimate current trends of female lifespan in South Korea based on reliable life tables from 1987 to 2016 taken from the Korean Statistical Information Service. This methodology enables us to perform quantitative and comparative analyses of female lifespan in South Korea with representative industrialized countries such as Japan, France, Australia, Switzerland, UK, Sweden, and USA. This analysis provides quantitative and comparative evidence that South Korea has the highest increase rate of female lifespan over the past three decades. Further application would be feasible for a better estimation of human aging statistics.

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“…There are scientists predicting that human life expectancy will be of 125 years by 2070 (De Beer, Bardoutsos, & Janssen, ). However, to get older in healthy conditions and with good life quality is even more important than living longer.…”

Section: Health‐promoting Potential Of Stbsmentioning

confidence: 99%

Resveratrol and Related Stilbenoids, Nutraceutical/Dietary Complements with Health‐Promoting Actions: Industrial Production, Safety, and the Search for Mode of Action

Navarro

Pinilla

Ortiz

et al. 2018

Comp Rev Food Sci Food Safe

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This paper reviews the potential of stilbenoids as nutraceuticals. Stilbenoid compounds in wine are considered key factors in health-promoting benefits. Resveratrol and resveratrol-related compounds are found in a large diversity of vegetal products. The stilbene composition varies from wine to wine and from one season to another. Therefore, the article also reviews how food science and technology and wine industry may help in providing wines and/or food supplements with efficacious concentrations of stilbenes. The review also presents results from clinical trials and those derived from genomic/transcriptomic studies. The most studied stilbenoid, resveratrol, is a very safe compound. On the other hand, the potential benefits of stilbene intake are multiple and are apparently due to downregulation more than upregulation of gene expression. The field may take advantage from identifying the mechanism of action(s) and from providing useful data to show evidence for specific health benefits in a given tissue or for combating a given disease.

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Maximum human lifespan may increase to 125 years

Cited by 47 publications

References 6 publications

The landscape of longevity across phylogeny

The landscape of longevity across phylogeny

Stretched Exponential Survival Analysis for South Korean Females

Resveratrol and Related Stilbenoids, Nutraceutical/Dietary Complements with Health‐Promoting Actions: Industrial Production, Safety, and the Search for Mode of Action

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