Maximum-Likelihood Joint Image Reconstruction/Motion Estimation in Attenuation-Corrected Respiratory Gated PET/CT Using a Single Attenuation Map

Bousse, Alexandre; Bertolli, Ottavia; Atkinson, David; Arridge, Simon; Ourselin, Sébastien; Hutton, Brian F.; Thielemans, Kris

doi:10.1109/tmi.2015.2464156

Cited by 46 publications

(90 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The motion-pattern can be estimated directly from the data, or can be obtained using an external motion-tracking device or MRI data. Motion correction can be incorporated in the reconstruction process [94][95][96].…”

Section: Accounting For Temporal Changesmentioning

confidence: 99%

Advances in clinical molecular imaging instrumentation

Hutton

Erlandsson

Thielemans

2018

Clin Transl Imaging

Self Cite

View full text Add to dashboard Cite

In this article, we describe recent developments in the design of both single-photon emission computed tomography (SPECT) and positron emission tomography (PET) instrumentation that have led to the current range of superior performance instruments. The adoption of solid-state technology for either complete detectors [e.g., cadmium zinc telluride (CZT)] or read-out systems that replace photomultiplier tubes [avalanche photodiodes (APD) or silicon photomultipliers (SiPM)] provide the advantage of compact technology, enabling flexible system design. In SPECT, CZT is well suited to multi-radionuclide and kinetic studies. For PET, SiPM technology provides MR compatibility and superior time-of-flight resolution, resulting in improved signal-to-noise ratio. Similar SiPM technology has also been used in the construction of the first SPECT insert for clinical brain SPECT/MRI.

show abstract

Section: Accounting For Temporal Changesmentioning

confidence: 99%

Advances in clinical molecular imaging instrumentation

Hutton

Erlandsson

Thielemans

2018

Clin Transl Imaging

Self Cite

View full text Add to dashboard Cite

show abstract

“…195 More in line with the topic of this review, in an integrated approach, others have formulated the likelihood as a function of warped activity and attenuation and deformation (maximum likelihood joint image reconstruction/motion estimation, ML-JRM); one then notes that only an arbitrarily warped µ-map is required to solve for λ and µ in all gates. 196 Using a similar algorithm (minimal MRI prior joint image reconstruction/motion estimation, MP-JRM), incomplete dynamic MRI information can also be integrated. 197 Reliance on prior information makes this approach resemble those in Sec.…”

Section: D Motion-aware Applicationsmentioning

confidence: 99%

Attenuation correction in emission tomography using the emission data—A review

Berker

2016

Medical Physics

View full text Add to dashboard Cite

The problem of attenuation correction (AC) for quantitative positron emission tomography (PET) had been considered solved to a large extent after the commercial availability of devices combining PET with computed tomography (CT) in 2001; single photon emission computed tomography (SPECT) has seen a similar development. However, stimulated in particular by technical advances toward clinical systems combining PET and magnetic resonance imaging (MRI), research interest in alternative approaches for PET AC has grown substantially in the last years. In this comprehensive literature review, the authors first present theoretical results with relevance to simultaneous reconstruction of attenuation and activity. The authors then look back at the early history of this research area especially in PET; since this history is closely interwoven with that of similar approaches in SPECT, these will also be covered. We then review algorithmic advances in PET, including analytic and iterative algorithms. The analytic approaches are either based on the Helgason-Ludwig data consistency conditions of the Radon transform, or generalizations of John's partial differential equation; with respect to iterative methods, we discuss maximum likelihood reconstruction of attenuation and activity (MLAA), the maximum likelihood attenuation correction factors (MLACF) algorithm, and their offspring. The description of methods is followed by a structured account of applications for simultaneous reconstruction techniques: this discussion covers organ-specific applications, applications specific to PET/MRI, applications using supplemental transmission information, and motion-aware applications. After briefly summarizing SPECT applications, we consider recent developments using emission data other than unscattered photons. In summary, developments using time-of-flight (TOF) PET emission data for AC have shown promising advances and open a wide range of applications. These techniques may both remedy deficiencies of purely MRI-based AC approaches in PET/MRI and improve standalone PET imaging. C

show abstract

“…Ideally, attenuation maps should be corrected for both cardiac and respiratory motion before the reconstruction of individual bins. However, this will require the use of more complex methods not yet available clinically (30).…”

Section: Tablementioning

confidence: 99%

Dual-Gated Motion-Frozen Cardiac PET with Flurpiridaz F 18

et al. 2015

View full text Add to dashboard Cite

A novel PET radiotracer, Flurpiridaz F 18, has undergone phase II clinical trial evaluation as a high-resolution PET cardiac perfusion imaging agent. In a subgroup of patients imaged with this agent, we assessed the feasibility and benefit of simultaneous correction of respiratory and cardiac motion. Methods: In 16 patients, PET imaging was performed on a 4-ring scanner in dual cardiac and respiratory gating mode. Four sets of data were reconstructed with high-definition reconstruction (HD•PET): ungated and 8-bin electrocardiographygated images using 5-min acquisition, optimal respiratory gating (ORG)-as developed for oncologic imaging-using a narrow range of breathing amplitude around end-expiration level with 35% of the counts in a 7-min acquisition, and 4-bin respiration-gated and 8-bin electrocardiography-gated images (32 bins in total) using the 7-min acquisition (dual-gating, using all data). Motion-frozen (MF) registration algorithms were applied to electrocardiography-gated and dual-gated data, creating cardiac-MF and dual-MF images. We computed wall thickness, wall/cavity contrast, and contrast-to-noise ratio for standard, ORG, cardiac-MF, and dual-MF images to assess image quality. Results: The wall/cavity contrast was similar for ungated (9.3 ± 2.9) and ORG (9.5 ± 3.2) images and improved for cardiac-MF (10.8 ± 3.6) and dual-MF images (14.8 ± 8.0) (P , 0.05). The contrast-to-noise ratio was 22.2 ± 9.1 with ungated, 24.7 ± 12.2 with ORG, 35.5 ± 12.8 with cardiac-MF, and 42.1 ± 13.2 with dual-MF images (all P , 0.05). The wall thickness was significantly decreased (P , 0.05) with dual-MF (11.6 ± 1.9 mm) compared with ungated (13.9 ± 2.8 mm), ORG (13.1 ± 2.9 mm), and cardiac-MF images (12.1 ± 2.7 mm). Conclusion: Dual (respiratory/cardiac)-gated perfusion imaging with Flurpiridaz F 18 is feasible and improves image resolution, contrast, and contrastto-noise ratio when MF registration methods are applied. (2) and better image quality, interpretative certainty, and diagnostic performance than SPECT in a phase 2 clinical trial (3). In particular, imaging with this 18 F-based radiotracer generated higher-resolution cardiac images (4).However, the high image resolution associated with an 18 F-based tracer can be degraded by cardiac and respiratory motion during PET acquisition, leading to image blurring. If such motion is not corrected, the full-potential imaging resolution of Flurpiridaz F 18 may not be realized. We have previously developed a motion-frozen (MF) technique for myocardial perfusion imaging, which recovers resolution lost due to cardiac motion, improving contrast and quantitative diagnostic accuracy (5,6). This technique was also successfully used for automatic coregistration of SPECT with CT angiography (CTA) (7,8) and for contrast improvement in cardiac PET (9).The aim of this study was to investigate the feasibility of myocardial perfusion imaging by Flurpiridaz F 18 PET with correction of both cardiac and respiratory motion. We hypothesized that the myocardial perfusion image quality for F...

show abstract

Maximum-Likelihood Joint Image Reconstruction/Motion Estimation in Attenuation-Corrected Respiratory Gated PET/CT Using a Single Attenuation Map

Cited by 46 publications

References 40 publications

Advances in clinical molecular imaging instrumentation

Advances in clinical molecular imaging instrumentation

Attenuation correction in emission tomography using the emission data—A review

Dual-Gated Motion-Frozen Cardiac PET with Flurpiridaz F 18

Contact Info

Product

Resources

About