2008
DOI: 10.1117/12.763833
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Maximum-likelihood position sensing and actively controlled electrokinetic transport for single-molecule trapping

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Cited by 13 publications
(7 citation statements)
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“…The need for large photon detection numbers has spurred the development of related methods, such as confocalized tracking with multiple point detectors ( 16 , 17 ), detection PSF engineering ( 18 ), Gaussian beam scanning schemes (i.e., orbital tracking) ( 19 24 ), and multiplexed excitation schemes ( 25 28 ). While all these methods provide specific advantages, none of them solved the need for large detection events , keeping the photon emission rate as the limiting factor for the obtainable spatiotemporal resolution.…”
mentioning
confidence: 99%
“…The need for large photon detection numbers has spurred the development of related methods, such as confocalized tracking with multiple point detectors ( 16 , 17 ), detection PSF engineering ( 18 ), Gaussian beam scanning schemes (i.e., orbital tracking) ( 19 24 ), and multiplexed excitation schemes ( 25 28 ). While all these methods provide specific advantages, none of them solved the need for large detection events , keeping the photon emission rate as the limiting factor for the obtainable spatiotemporal resolution.…”
mentioning
confidence: 99%
“…However, finite-volume time-domain numerical modeling has predicted that a simpler configuration of just four electrodes in a tetrahedral arrangement should suffice to form an electric field of controllable orientation and strength. 17,18 Thus, not only can a nanoparticle be trapped but its position may also be manipulated by adjusting the electrode voltages.…”
mentioning
confidence: 85%
“…The approach involves use of four laser foci arranged in a tetrahedron to provide 3-D spatial information and also four electrodes arranged in a tetrahedron to provide 3-D electrokinetic motion. 17 …”
Section: Discussionmentioning
confidence: 99%
“…13 Maximum-likelihood data analysis strategies for sensing the position of a single molecule within a trap have also been described. 17 This paper discusses Monte Carlo computer simulations of the successive delivery and 1-D trapping of single molecules within a nanochannel. The simulations provide a means for developing and testing algorithms that may be implemented in software within a field-programmable gate array ͑FPGA͒, which is a part of the hardware for controlling the electrokinetic voltages of the single-molecule trap.…”
Section: Introductionmentioning
confidence: 99%