Maximum standardised uptake value of quantitative bone SPECT/CT in patients with medial compartment osteoarthritis of the knee

Kim, J.; Lee, H. H.; Kang, Yusuhn; Kim, T. K.; Lee, S. W.; So, Young; Lee, Won Woo

doi:10.1016/j.crad.2017.03.009

Cited by 61 publications

(53 citation statements)

References 35 publications

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“…The choice to use mrBTU values instead of mean related BTU values was due to the fact that mrBTU values allow a direct comparability between SPECT/CT images of different patients and compensate for inter‐ and intra‐patient variability. Maximal relative BTU values are highly reproducible and do not depend from the volume and location of the region of interest . In this study mrBTUs showed excellent ICC scores and should be used as standard for further studies concerning the comparison of the BTU distribution and intensity on SPECT/CT of different patients …”

Section: Discussionmentioning

confidence: 59%

“…In a recent meta‐analysis of Zhang et al MRI images were seen to have an overall 75% sensitivity and a 94% specificity in diagnosing knee chondral lesions when compared with arthroscopic findings graded accorded to the ICRS . A major concern and limitation of classifying cartilage lesions on MRI is the subjectivity and variability of measurements such as T2 mapping, which might be different dependent from the system used and the individual observer …”

Section: Discussionmentioning

confidence: 99%

“…SPECT/CT on the contrary, measures the intensity and distribution of the bone tracer (BTU), an objective measure which is at least not observer dependent . The dependency on the system used has not been investigate yet.…”

Section: Discussionmentioning

confidence: 99%

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Good correlation between bone tracer uptake in SPECT/CT and intraoperative findings of chondral lesions graded with the ICRS scoring

Ammann

Schiapparelli

Moser

et al. 2018

Journal Orthopaedic Research

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The question if bone tracer uptake in SPECT/CT reflects the intraoperative cartilage status of the knee is still unanswered. In this study, thirty-three consecutive patients (male:female ¼ 11:22; mean age AE standard deviation 61 AE 15) with bi-or tri-compartmental knee osteoarthritis who underwent SPECT/CT before total knee arthroplasty (TKA) were collected. The knee was graded in eleven different anatomical regions. In each region, the maximal relative bone tracer uptake (mrBTU) was measured twice by two observers with a six weeks interval. The intraclass correlation coefficients (ICC) showed excellent correlations and mean values were used. Intraoperatively every region was assessed with the macroscopic International Cartilage Repair Society (ICRS) scoring. A factorial analysis and a non-parametrical Spearman's correlation were calculated among the 11 knee regions on both mrBTU and ICRS scores and significant correlations were seen between regions belonging to the same knee compartment (p < 0.05). A non-parametrical Spearman's correlation was also performed to investigate the correlation between rmBTU in SPECT/CT and intraoperative ICRS cartilage grading. Significant correlations were seen on the medial compartment, on the proximal femoral trochlea and on the medial patellar facet (p < 0.05). A significant correlation between SPECT/CT and intraoperative findings was so demonstrated in several regions. The low accuracy of the macroscopic ICRS scoring system on grade I-II lesions could have affected the missing correlations on the lateral compartment since the selected presented mainly a varus gonarthrosis. The use of an objective measure as the rmBTU could overcome the limit of the subjectivity of MRI findings in early osteoarthritis. ß

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

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Good correlation between bone tracer uptake in SPECT/CT and intraoperative findings of chondral lesions graded with the ICRS scoring

Ammann

Schiapparelli

Moser

et al. 2018

Journal Orthopaedic Research

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“…Цифрові параметри повинні бути точними, мати клінічне значення і бути специфічними для конкретних діагностичних умов. Візуальне сортування для визначення дискретних чисел для моделей поглинання є напівкількісним підходом, що може доповнювати клінічні звіти з числовими даними [1,22]. Однак це суб'єктивний метод, що не завжди відображає клінічну картину.…”

Section: рисунок 1 a -планарна остеосцинтиграфія всього тіла в передunclassified

Перспективы Количественной Оценки Результатов Однофотонной Эмиссионной Компьютерной Томографии Костной Системы (Обзор Литературы)

Korol¹,

Samokhin²,

Ткаченко³

2021

TRAUMA

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В обзоре литературы рассмотрены вопросы перспективы количественной оценки результатов однофотонной эмиссионной компьютерной томографии (ОФЭКТ) костной системы. Синтез функциональной информации, полученной с помощью ОФЭКТ в комплексе с высоким разрешением КТ, позволяет эффективно определять патологический метаболизм в костях с одновременной оценкой сосуществующих структурных изменений. Показатели максимального процента стандартизированного накопления (ПСН) радиофармпрепарата (РФП) и пикового процента стандартизированного накопления следует считать наиболее оптимальными параметрами количественного определения фокального поглощения РФП. В дальнейшем необходимо привлекать более узкие подгруппы больных (например, по возрасту, росту, массе, полу и т.д.), имеющих специфические условия, для того чтобы создать соответствующую доказательную базу. Однако необходимы дальнейшие технологические усовершенствования для того, чтобы расчет количественных параметров ОФЭКТ путем вычисления ПСН стал частью обычной медицинской практики.

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“…Regarding nuclear medicine, Kim et al 77 studied the uptake of Tc-99m-HDP radiotracer to bone in patients scheduled for TKA with comparison to radiographic and MRI evaluation. Operated knees had a higher maximum standardized uptake value (SUVmax) than nonoperated knees in the medial compartment.…”

Section: Ct and Nuclear Medicinementioning

confidence: 99%

Osteoarthritis year in review 2018: imaging

Nieminen

Casula

Nevalainen

et al. 2019

Osteoarthritis and Cartilage

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Purpose: To provide a narrative review of the most relevant original research published in 2017/2018 on osteoarthritis imaging. Methods: The PubMed database was used to recover all relevant articles pertaining to osteoarthritis and medical imaging published between 1 April 2017 and 31 March 2018. Review articles, case studies and in vitro or animal studies were excluded. The original publications were subjectively sorted based on relevance, novelty and impact. Results and conclusions: The publication search yielded 1,155 references. In the assessed publications, the most common imaging modalities were radiography (N ¼ 708) and magnetic resonance imaging (MRI) (355), followed by computed tomography (CT) (220), ultrasound (85) and nuclear medicine (17). An overview of the most important publications to the osteoarthritis (OA) research community is presented in this narrative review. Imaging studies play an increasingly important role in OA research, and have helped us to understand better the pathophysiology of OA. Radiography and MRI continue to be the most applied imaging modalities, while quantitative MRI methods and texture analysis are becoming more popular. The value of ultrasound in OA research has been demonstrated. Several multi-modality predictive models have been developed. Deep learning has potential for more automatic and standardized analyses in future OA imaging research.

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Maximum standardised uptake value of quantitative bone SPECT/CT in patients with medial compartment osteoarthritis of the knee

Cited by 61 publications

References 35 publications

Good correlation between bone tracer uptake in SPECT/CT and intraoperative findings of chondral lesions graded with the ICRS scoring

Good correlation between bone tracer uptake in SPECT/CT and intraoperative findings of chondral lesions graded with the ICRS scoring

Перспективы Количественной Оценки Результатов Однофотонной Эмиссионной Компьютерной Томографии Костной Системы (Обзор Литературы)

Osteoarthritis year in review 2018: imaging

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