Maximum Standardized Uptake Value of Pelvic Lymph Nodes in [18F]-Fluorodeoxyglucose Positron Emission Tomography Is a Prognostic Factor for Para-Aortic Lymph Node Recurrence in Pelvic Node-Positive Cervical Cancer Treated With Definitive Chemoradiotherapy

Kim, Dong Hyun; Kim, Won Taek; Bae, Jin Suk; Ki, Yongkan; Park, Dahl; Suh, Dong Soo; Kim, Ki Hyung; Lee, Joo Hye; Lee, Ja Young; Jeon, Hosang; Nam, Jin Hyun

doi:10.1097/igc.0000000000000772

Cited by 12 publications

(7 citation statements)

References 22 publications

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“…Of these, 348 publications unrelated to the study were excluded by carefully reading the title and abstract, and the remaining 39 publications were further examined by screening the full text. Finally, 17 publications were studied, including 4 that simultaneously analyzed overall survival (OS) and progression-free survival (PFS) as prognostic indicators, 4 that analyzed OS and disease-free survival (DFS) as prognostic indicators, 5 studied with DFS alone, 3 articles with the most endpoints of OS alone, and 1 studied with PFS alone (Figure 1) [6–22]. The publication period of the literature was between 2003 and 2017.…”

Section: Resultsmentioning

confidence: 99%

Prognostic Role of Squamous Cell Carcinoma Antigen in Cervical Cancer: A Meta-analysis

Liu¹,

Shi

2019

Disease Markers

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Objective. To systematically evaluate the significance of squamous cell carcinoma antigen (SCC-Ag) in the prognosis of cervical cancer. Methods. Literature from Pubmed, Embase, and Cochrane Library was retrieved to collect all English literature on the correlation between SCC-Ag and cervical cancer prognosis, and the quality of literature collected was assessed based on evaluation criteria. The heterogeneity, sensitivity, and specificity were detected using the StataSE12.0 software, and the correlation between SCC-Ag and cervical cancer prognosis as the effect variables was assessed using the hazard ratio (HR) and 95% confidence interval (CI). Moreover, the forest map and funnel plot were drawn. Results. A total of 17 articles meeting the inclusion criteria were selected. The high expression of SCC-Ag was significantly correlated with the poor prognosis of cervical cancer (HR=2.22, 95% CI=1.38−3.57, P=0.002). The disease-free survival (DFS) was higher in low SCC-Ag expression patients than in high SCC-Ag expression patients (HR=2.17, 95% CI=1.84−2.57, P<0.001). The progression-free survival (PFS) was inferior in patients with a high SCC-Ag expression (HR=2.70, 95% CI=1.11−6.53, P=0.028). Conclusion. SCC-Ag is an important prognostic factor for cervical cancer, and its high expression is significantly correlated with a poor prognosis of the disease.

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Section: Resultsmentioning

confidence: 99%

Prognostic Role of Squamous Cell Carcinoma Antigen in Cervical Cancer: A Meta-analysis

Liu¹,

Shi

2019

Disease Markers

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“…Para-aortic nodal control can be addressed through pre-therapeutic laparoscopic para-aortic lymph node dissection or by increasing the use of para-aortic irradiation in selected patients with nodal involvement at diagnosis who are at higher risk of para-aortic and distant relapse. The number of nodes (≥3), location (common iliac), PET avidity [69] , [70] , [71] , and to a lesser extent size of nodes [72] , may be predictors of para-aortic and systemic failure. Systematic prophylactic para-aortic irradiation in node-positive patients has been shown to produce high levels of nodal control in mono-institutional reports [73] .…”

Section: The Embrace II Study – Rationale For Change Of Practicementioning

confidence: 99%

The EMBRACE II study: The outcome and prospect of two decades of evolution within the GEC-ESTRO GYN working group and the EMBRACE studies

Pötter

Tanderup

Kirisits

et al. 2018

Clinical and Translational Radiation Oncology

497

441

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“…Regarding the prognostic value of the size of lymph node metastasis measured by imaging modalities, Wang et al have reported that in patients treated with de nitive radiotherapy, the presence of three or more lymph nodes ≥ 1 cm in short axis diameter measured by CT or MRI was an independent prognostic factor for overall survival 17 21 . This nding suggests that 18 F-FDG PET might be also a prognostic biomarker in cervical cancer, although no previous study has compared its utility as a prognostic biomarker between size measured by imaging modalities and uptake of 18 F-FDG PET.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of 18F-FDG PET in uterine cervical cancer patients with stage IIICr allocated by imaging

Isaji

Tsuyoshi

Tsujikawa

et al. 2023

Preprint

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Background The effect on survival of radiographic lymph node metastasis in uterine cervical cancer patients is more important than before, even though its prognostic value not been well investigated. The aim of our study is to evaluate the prognostic potential of 18F-FDG PET imaging in uterine cervical cancer patients with stage IIICr allocated by imaging. Methods Fifty-five patients with biopsy-proven primary cervical cancer underwent definitive radiation therapy for stages IIB–IVB of the 2018 FIGO 2018 classifications. The prognostic performance of pretreatment 18F-FDG PET and CT for assessing lymph node metastasis was evaluated by two experienced readers. The PET and CT findings were correlated with the risk of progression-free survival (PFS) and overall survival (OS). Results Kaplan–Meier survival curves showed that PFS was significantly worse in patients with FDG uptake in lymph nodes than in those patients with no FDG uptake (p = 0.003), whereas there was no significant difference in PFS between patients with lymph nodes sized ≥ 1 cm and those sized < 1 cm (p = 0.140). Univariate analysis showed that FDG uptake in lymph nodes was significantly associated with poor PFS (p = 0.006), whereas lymph node size was not significantly associated with poor PFS (p = 0.145). In multivariate analysis, FDG uptake in lymph nodes was significantly associated with poor PFS (p = 0.006) and was an independent prognostic factor for PFS. Conclusions 18F-FDG PET offers high prognostic value for patients with stage IIICr allocated by imaging, suggesting that 18F-FDG PET might be useful in clinical staging decisions and thus promote optimal diagnostic and therapeutic strategies.

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Maximum Standardized Uptake Value of Pelvic Lymph Nodes in [18F]-Fluorodeoxyglucose Positron Emission Tomography Is a Prognostic Factor for Para-Aortic Lymph Node Recurrence in Pelvic Node-Positive Cervical Cancer Treated With Definitive Chemoradiotherapy

Abstract: SUVPLN is a statistically significant prognostic factor of PALN recurrence and survival after definitive CCRT for pelvic node-positive SCC of the uterine cervix.

Cited by 12 publications

References 22 publications

Prognostic Role of Squamous Cell Carcinoma Antigen in Cervical Cancer: A Meta-analysis

Prognostic Role of Squamous Cell Carcinoma Antigen in Cervical Cancer: A Meta-analysis

The EMBRACE II study: The outcome and prospect of two decades of evolution within the GEC-ESTRO GYN working group and the EMBRACE studies

Prognostic value of 18F-FDG PET in uterine cervical cancer patients with stage IIICr allocated by imaging

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