May polyenthesitis follow COVID-19?

Ciaffi, Jacopo; Mancarella, Luana; Borlandelli, Elena; Facchini, Giancarlo; Melicòni, Riccardo; Ursini, Francesco

doi:10.1016/j.jbspin.2021.105158

Cited by 3 publications

(5 citation statements)

References 8 publications

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“…was positive in 5 cases out of 8 [3,5,7,9]. Individuals with the HLA-B27 allele or with a family history of SpA have a higher The transcriptomic profiling has not drawn any conclusion in our analysis, and the result might be attributable to inter-individual differences and medication status.…”

Section: Discussionmentioning

confidence: 63%

“…To study more about SpA after COVID-19, we performed a comprehensive review of the literature. A total 8 cases from 7 papers were classified as SpA according to ASAS criteria ( Table 1 ) [ 3 , 5 - 10 ]. The median age of these cases was 44 years old (range: 21~65 years).…”

Section: Discussionmentioning

confidence: 99%

“…Enthesitis was reported in one case. There were no cases with dactylitis [ 9 ]. Psoriasis was present in 2 cases [ 6 , 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…Our two cases were also males with axial involvement and elevated CRP. HLA-B27 was positive in 5 cases out of 8 [ 3 , 5 , 7 , 9 ]. Individuals with the HLA-B27 allele or with a family history of SpA have a higher risk of developing reactive arthritis [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

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Development of Spondyloarthritis After COVID-19 in HLAB27-Positive Monozygotic Twins: Case Reports With Single Cell Transcriptome Profiling

Kim

Baek³

2022

J Rheum Dis

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A subset of spondyloarthritis (SpA) called 'reactive arthritis' is triggered by causal pathogens, usually bacteria related to venereal disease or gastrointestinal infection. During the outbreak of coronavirus disease 2019 (COVID-19), there have been case reports about SpA after COVID-19, but the causality is still elusive. We described cases of 23-year-old monozygotic twins both diagnosed with SpA after COVID-19. The probable linkage between SpA and COVID-19 was elaborated with our cases as well as literature reviews. Of note, shared genetic traits by monozygotic twins, particularly HLA-B27 positivity, might have contributed to their susceptibility to COVID-19-induced SpA. Moreover, single-cell transcriptome analysis revealed that the transcriptomic profile of peripheral compartment of SpA after COVID-19 was distinctive from that of typical radiographic axial SpA as shown by differential expression of ribosomal protein S26 (RPS26) and small nucleolar RNA host gene 5 (SNHG5) in nearly all subsets of peripheral blood mononuclear cells.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

“…Enthesitis was reported in one case. There were no cases with dactylitis [ 9 ]. Psoriasis was present in 2 cases [ 6 , 10 ].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Development of Spondyloarthritis After COVID-19 in HLAB27-Positive Monozygotic Twins: Case Reports With Single Cell Transcriptome Profiling

Kim

Baek³

2022

J Rheum Dis

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“…Not surprisingly, musculoskeletal symptoms are reported in a significant proportion of post-COVID-19 patients [8]. A growing number of articles described new-onset rheumatic musculoskeletal diseases developing in close temporal association with COVID-19, including rheumatoid arthritis (RA) [9], polymyalgia rheumatica (PMR) [10], reactive arthritis [11], axial spondyloarthritis [12], polyenthesitis [13] and connective tissue diseases [14][15][16]. Furthermore, current evidence suggests not only that various autoantibodies can be found in the sera of individuals recovered from SARS-CoV-2 infection [17][18][19], but also that the long-lasting presence of autoantibodies might be associated with persisting symptoms and residual inflammation [20].…”

Section: Introductionmentioning

confidence: 99%

Post-Acute COVID-19 Joint Pain and New Onset of Rheumatic Musculoskeletal Diseases: A Systematic Review

et al. 2023

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As the number of reports of post-acute COVID-19 musculoskeletal manifestations is rapidly rising, it is important to summarize the current available literature in order to shed light on this new and not fully understood phenomenon. Therefore, we conducted a systematic review to provide an updated picture of post-acute COVID-19 musculoskeletal manifestations of potential rheumatological interest, with a particular focus on joint pain, new onset of rheumatic musculoskeletal diseases and presence of autoantibodies related to inflammatory arthritis such as rheumatoid factor and anti-citrullinated protein antibodies. We included 54 original papers in our systematic review. The prevalence of arthralgia was found to range from 2% to 65% within a time frame varying from 4 weeks to 12 months after acute SARS-CoV-2 infection. Inflammatory arthritis was also reported with various clinical phenotypes such as symmetrical polyarthritis with RA-like pattern similar to other prototypical viral arthritis, polymyalgia-like symptoms, or acute monoarthritis and oligoarthritis of large joints resembling reactive arthritis. Moreover, high figures of post-COVID-19 patients fulfilling the classification criteria for fibromyalgia were found, ranging from 31% to 40%. Finally, the available literature about prevalence of rheumatoid factor and anti-citrullinated protein antibodies was largely inconsistent. In conclusion, manifestations of rheumatological interest such as joint pain, new-onset inflammatory arthritis and fibromyalgia are frequently reported after COVID-19, highlighting the potential role of SARS-CoV-2 as a trigger for the development of autoimmune conditions and rheumatic musculoskeletal diseases.

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Achilles tendinopathy following severe acute respiratory syndrome coronavirus 2 infection and COVID-19 vaccination

Adwan,

Asfour,

Abuhelal

2024

Arab Journal of Rheumatology

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Musculoskeletal symptoms are commonly reported following SARS-CoV-2 infection, with fatigue, arthralgia, and myalgia being the most common manifestations. Severe cases may include conditions like arthritis and rhabdomyolysis. Similarly, post-vaccination musculoskeletal symptoms have been documented. However, tendinopathy, particularly Achilles tendinopathy, remains underreported in both contexts. We present two cases of Achilles tendinopathy, one following SARS-CoV-2 infection and the other post-vaccination, to highlight potential musculoskeletal complications associated with COVID-19 and vaccination. In the first case, a 48-year-old male developed bilateral ankle pain eight weeks after a confirmed COVID-19 infection. The second case involves a 27-year-old male who experienced sudden, intense left Achilles tendon pain following SARS-CoV-2 vaccination. Case 1: The 48-year-old patient exhibited bilateral ankle pain and swelling, with MRI confirming Achilles enthesitis. Laboratory tests showed elevated ESR and CRP, with other parameters within normal ranges. Treatment with sulfasalazine led to significant improvement. Case 2: The 27-year-old patient demonstrates Achilles tendon rupture post-vaccination. Detailed findings and treatment outcomes were discussed to emphasize the rarity and significance of this condition. These two cases underscore the need for awareness and further research on the relatively serious musculoskeletal complications like Achilles tendinopathy following COVID-19 infection and vaccination. Enhanced medical understanding is crucial for optimizing patient care and addressing potential side effects effectively.

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May polyenthesitis follow COVID-19?

Cited by 3 publications

References 8 publications

Development of Spondyloarthritis After COVID-19 in HLAB27-Positive Monozygotic Twins: Case Reports With Single Cell Transcriptome Profiling

Development of Spondyloarthritis After COVID-19 in HLAB27-Positive Monozygotic Twins: Case Reports With Single Cell Transcriptome Profiling

Post-Acute COVID-19 Joint Pain and New Onset of Rheumatic Musculoskeletal Diseases: A Systematic Review

Achilles tendinopathy following severe acute respiratory syndrome coronavirus 2 infection and COVID-19 vaccination

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