May Ultrasonography Diagnosed Hepatic Steatosis Be Predictor of Metabolic Syndrome Among Aviators?

Tanoğlu, Alpaslan; Aparcı, Mustafa; Aktas, Gokcen Okur; Karaduman, Mehmet; Öztürk, Cengiz; Kaplan, Mustafa; Okutucu, Sercan

doi:10.5455/dmm.20160126121441

Cited by 2 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 8 ] Interestingly, a previous report suggested that hepatic steatosis could serve as a reliable marker of MS and could be non-invasively screened in aviators using abdominal ultrasound. [ 26 ] The authors concluded that liver steatosis could play a crucial role in identifying aviators who require further cardiovascular evaluation and guiding lifestyle modifications. [ 26 ] In the future, a rigorous cost-effectiveness analysis comparing these two techniques should be conducted.…”

Section: Discussionmentioning

confidence: 99%

“…[ 26 ] The authors concluded that liver steatosis could play a crucial role in identifying aviators who require further cardiovascular evaluation and guiding lifestyle modifications. [ 26 ] In the future, a rigorous cost-effectiveness analysis comparing these two techniques should be conducted. Thirdly, due to the specific focus of our research project on APs volunteering for TE, we lacked data on lipid parameters and serum aminotransferases, which are necessary for diagnosing MS.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of hepatic steatosis and fibrosis in apparently healthy airline pilots: a transient elastography study

Minoretti

2023

Hepatology Forum

View full text Add to dashboard Cite

Background and Aim Airline pilots (APs) are often characterized by a sedentary lifestyle, predisposing them to adverse cardiometabolic consequences. In this cross-sectional study, we used transient elastography (TE) to investigate the prevalence of hepatic steatosis and fibrosis among apparently healthy APs. Materials and Methods The study cohort consisted of 137 male APs of Caucasian descent who voluntarily underwent TE. To evaluate the extent and severity of hepatic steatosis and fibrosis, we employed established cutoff values for the controlled attenuation parameter (CAP) and liver stiffness measurement (LSM). Results Of the APs, 34 (24.8%) were diagnosed with TE-defined steatosis. Specifically, 25 APs (18.2%) exhibited mild steatosis, 6 (4.4%) moderate steatosis, and 3 (2.2%) severe steatosis. The majority of participants (80 APs or 58.4%) showed no signs of liver fibrosis based on LSM values. However, 49 APs (35.8%) were diagnosed with mild fibrosis (F1), 7 (5.1%) with significant fibrosis (F2), and one (0.7%) with advanced fibrosis (F3). None of the pilots had F4 (cirrhosis). In multivariable linear regression analysis, BMI was the sole independent predictor of both CAP (β=0.34, p<0.001) and LSM (β=0.41, p<0.001) values in our sample of male APs. Conclusion TE is a straightforward and convenient non-invasive method for detecting hepatic steatosis and fibrosis in high-risk occupational groups such as APs.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prevalence of hepatic steatosis and fibrosis in apparently healthy airline pilots: a transient elastography study

Minoretti

2023

Hepatology Forum

View full text Add to dashboard Cite

show abstract

“…NAFLD has the potential to progress from simple liver steatosis (nonalcoholic fatty liver, NAFL) to nonalcoholic steatohepatitis (NASH), hepatic fibrosis, cirrhosis, and liver cancer. This risk is highest in people with liver fibrosis, and fibrosis is a precursor to the risk of morbidity [5,6]. The main aim is to early detect and treat individuals with progressive disease among NAFLD patients, which are commonly observed in the society.…”

Section: Introductionmentioning

confidence: 99%

In the Diagnosis of Liver Fibrosis Developing in Nonalcoholic Fatty Liver Patients; Could Serum Fetuin A Be a Candidate Biomarker

Akyol

2023

lms

View full text Add to dashboard Cite

Previous studies have reported in the literature that fetuin A, released from the liver, may be a useful serum biomarker in the diagnosis of nonalcoholic fatty liver disease (NAFLD). However, results are not consistent in predicting nonalcoholic steatohepatitis (NASH) and fibrosis, which are indicative of progressive NAFLD patients. The aim of this study was to investigate the importance of serum fetuin A in detecting NASH and fibrosis, which are determinants of morbidity, in patients with liver biopsy-proven NAFLD. This observational case-control study included 40 NAFLD patients diagnosed by liver biopsy and 25 healthy volunteer controls. The demographic characteristics of the patients and healthy volunteers were recorded, biochemical tests were done, and the serum fetuin A levels of the participants were determined by the enzyme-linked immunosorbent assay method. Serum fetuin A levels were significantly higher in both the nonalcoholic fatty liver (NAFL) (608.30 μg/mL; p<0.001) and NAFLD (536.58 μg/mL; p=0.008) groups compared to the control group (345.07 μg/mL). However, no significant difference was detected in the NASH group (417.06 μg/mL; p=0.740). When patients with and without fibrosis were compared, the mean serum fetuin A levels of patients with fibrosis were significantly lower (708 μg/mL and 380 μg/mL, respectively; p<0.001). When receiver operating characteristic (ROC) analysis was performed, the best cut-off point for patients with fibrosis was 510.98 μg/mL with 94.7% sensitivity and 66.7% specificity (p<0.001). Serum fetuin A may be a useful biomarker in the diagnosis of NAFLD patients and in predicting liver fibrosis.

show abstract

May Ultrasonography Diagnosed Hepatic Steatosis Be Predictor of Metabolic Syndrome Among Aviators?

Cited by 2 publications

References 0 publications

Prevalence of hepatic steatosis and fibrosis in apparently healthy airline pilots: a transient elastography study

Prevalence of hepatic steatosis and fibrosis in apparently healthy airline pilots: a transient elastography study

In the Diagnosis of Liver Fibrosis Developing in Nonalcoholic Fatty Liver Patients; Could Serum Fetuin A Be a Candidate Biomarker

Contact Info

Product

Resources

About