Mayak Worker Study: An Improved Biokinetic Model for Reconstructing Doses from Internally Deposited Plutonium

Abstract

The plutonium production facility known as the Mayak Production Association was put into operation in June 1948. A high incidence of cancer in the Mayak workers has been related to the level of exposure to plutonium, but uncertainties in tissue doses have hampered development of dose-risk relationships. As part of an effort to improve dose estimates for these workers, the systemic biokinetic model for plutonium currently recommended by the International Commission on Radiological Protection (ICRP) has been modified to reflect recently developed data and facilitate interpretation of case-specific information. This paper describes the proposed model and discusses its implications for dose reconstruction for the Mayak workers.

Mortality from Circulatory System Diseases among French Uranium Miners: A Nested Case-Control Study

“…For example, for plutonium the main sites of deposition would be the lung, liver and bone with very little exposure to organs such as the heart (44). Thus, the choice of target organ for the analysis will influence the likely contribution of internal exposures to a worker's total radiation dose, but there is no consensus on the most appropriate target organ for use in the analysis of circulatory diseases.…”

Assessment of Dose to the Nursing Infant from Radionuclides in Breast Milk

“…The model used in the present report (Leggett et al, 2005) is an update of the model of ICRP Publication 67. This updated model is also adapted to include transfers from blood plasma to breast to milk and applied to the mother.…”

“…This updated model is also adapted to include transfers from blood plasma to breast to milk and applied to the mother. The structure and parameter values of the updated model are given in Appendix E. The reader is referred to the paper by Leggett et al (2005) for a discussion of the basis of the updated model.…”

“…The basis for the updated model is described in a publication by Leggett et al (2005). The model structure and parameter values are given below.…”

Modélisation de la décorporation du Pu/am par le dtpa

“…Cet article propose un premier outil logiciel couplant le modèle systémique de Leggett pour le Pu (Leggett et al, 2005) avec un modèle décrivant la formation des complexes Pu-DTPA et leur excrétion urinaire qui permettrait d'optimiser les protocoles thérapeutiques sur la base d'une réduction des doses efficaces. Il valide certaines hypothèses retenues pour la modélisation à partir de données animales récemment publiées, et précise la structure d'un nouveau modèle, mieux adapté, qui pourrait être applicable à la fois au Pu et à l'Am et qui serait transposable à l'homme pour différents protocoles de traitements par diverses posologies et formes galéniques de DTPA.…”