Mayaro Virus Infection, Amazon Basin Region, Peru, 2010–2013

Halsey, Eric S.; Siles, Crystyan; Guevara, Carolina; Vilcarromero, Stalin; Jhonston, Erik J.; Ramal, Cesar; Aguilar, Patricia V.; Ampuero, Julia S.

doi:10.3201/eid1911.130777

Cited by 115 publications

(111 citation statements)

References 14 publications

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“…Our future work will focus on longer follow-up times and quality of life, as we have done for other arboviruses. 35 …”

Section: Discussionmentioning

confidence: 99%

“…The 7.7% frequency of symptom persistence in our DENV-infected subjects was less than what we observed in febrile controls and lower than what prior studies reported in infection with other arboviruses. 23,[33][34][35][36] However, assuming 96 million people suffer from acute, symptomatic DENV infection annually, this represents a potential disease burden of 7.4 million cases, a substantial number. 1 We hope that our results will better inform patients-and their family members, physicians, and employers-of what to expect in the weeks after DENV infection.…”

Section: Discussionmentioning

confidence: 99%

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Occurrence and Correlates of Symptom Persistence Following Acute Dengue Fever in Peru

Halsey¹,

Williams²,

Laguna-Torres³

et al. 2014

The American Society of Tropical Medicine and Hygiene

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Abstract. Dengue virus (DENV) infection causes an acute febrile illness generally considered to result in either complete recovery or death. Some reviews describe persistent symptoms after the febrile phase, although empirical data supporting this phenomenon is scarce. We evaluated symptom persistence in acute febrile DENV-infected and DENVnegative (controls) individuals from Peru. Self-reported solicited symptoms were evaluated at an acute and a follow-up visit, occurring 10-60 days after symptom onset. Rate of persistence of at least one symptom was 7.7% and 10.5% for DENV infected and control subjects, respectively (P 0.01). The DENV-infected individuals had lower rates of persistent respiratory symptoms, gastrointestinal symptoms, headache, and fatigue, but higher rates of persistent rash compared with controls. Older age and female gender were positively associated with symptom persistence. As dengue cases continue to increase annually, even a relatively low frequency of persistent symptoms may represent a considerable worldwide morbidity burden.

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“…Our future work will focus on longer follow-up times and quality of life, as we have done for other arboviruses. 35 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Occurrence and Correlates of Symptom Persistence Following Acute Dengue Fever in Peru

Halsey¹,

Williams²,

Laguna-Torres³

et al. 2014

The American Society of Tropical Medicine and Hygiene

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“…Human infections caused by MAYV have been described in several countries, including Trinidad, 12 Bolivia, 13,14 French Guiana, 15 Peru, 14,16 Venezuela, 17 and Brazil. 7,18,19 In 1978, during an epidemic in Belterra, Pará State, Brazil, the virus was isolated from 43 patients.…”

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confidence: 99%

Isolation and Characterization of Mayaro Virus from a Human in Acre, Brazil

Terzian¹,

Auguste²,

Vedovello³

et al. 2015

The American Society of Tropical Medicine and Hygiene

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Abstract. Mayaro virus (MAYV) is widely distributed throughout South America and is the etiologic agent of Mayaro fever, an acute febrile illness often presenting with arthralgic manifestations. The true incidence of MAYV infection is likely grossly underestimated because the symptomatic presentation is very similar to that of dengue fever and other acute febrile tropical diseases. We report the complete genome sequence of a MAYV isolate detected from an Acrelâ ndia patient presenting with fever, chills, and sweating, but with no arthralgia. Results show that this isolate belongs to genotype D and is closely related to Bolivian strains. Our results suggest that the Acre/Mayaro strain is closely related to the progenitor of these Bolivian strains that were isolated between 2002 and 2006.

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“…Samples were collected and archived as part of a study to determine the etiology of febrile illnesses in Latin America. The criteria for inclusion in this study required subjects to present to selected health facilities with an elevated temperature (Ն38°C oral, tympanic, or (Table 2) as previously described (11,17,23). For positive samples, convalescent-phase samples were collected within 10 to 30 days postdiagnosis and EIAs for IgM and IgG were performed as previously described (Table 2) (11,17).…”

Section: Methodsmentioning

confidence: 99%

Human Antibody Responses to Emerging Mayaro Virus and Cocirculating Alphavirus Infections Examined by Using Structural Proteins from Nine New and Old World Lineages

Smith

Pugh

Cisney

et al. 2018

mSphere

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Mayaro virus (MAYV), Venezuelan equine encephalitis virus (VEEV), and chikungunya virus (CHIKV) are vector-borne alphaviruses that cocirculate in South America. Human infections by these viruses are frequently underdiagnosed or misdiagnosed, especially in areas with high dengue virus endemicity. Disease may progress to debilitating arthralgia (MAYV, CHIKV), encephalitis (VEEV), and death. Few standardized serological assays exist for specific human alphavirus infection detection, and antigen cross-reactivity can be problematic. Therefore, serological platforms that aid in the specific detection of multiple alphavirus infections will greatly expand disease surveillance for these emerging infections. In this study, serum samples from South American patients with PCR-and/or isolation-confirmed infections caused by MAYV, VEEV, and CHIKV were examined by using a protein microarray assembled with recombinant capsid, envelope protein 1 (E1), and E2 from nine New and Old World alphaviruses. Notably, specific antibody recognition of E1 was observed only with MAYV infections, whereas E2 was specifically targeted by antibodies from all of the alphavirus infections investigated, with evidence of cross-reactivity to E2 of o'nyong-nyong virus only in CHIKV-infected patient serum samples. Our findings suggest that alphavirus structural protein microarrays can distinguish infections caused by MAYV, VEEV, and CHIKV and that this multiplexed serological platform could be useful for high-throughput disease surveillance.IMPORTANCE Mayaro, chikungunya, and Venezuelan equine encephalitis viruses are closely related alphaviruses that are spread by mosquitos, causing diseases that produce similar influenza-like symptoms or more severe illnesses. Moreover, alphavirus infection symptoms can be similar to those of dengue or Zika disease, leading to underreporting of cases and potential misdiagnoses. New methods that can be used to detect antibody responses to multiple alphaviruses within the same assay would greatly aid disease surveillance efforts. However, possible antibody cross-reactivity between viruses can reduce the quality of laboratory results. Our results demonstrate that antibody responses to multiple alphaviruses can be specifically quantified within the same assay by using selected recombinant protein antigens and further show that Mayaro virus infections result in unique responses to viral envelope proteins.

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Mayaro Virus Infection, Amazon Basin Region, Peru, 2010–2013

Cited by 115 publications

References 14 publications

Occurrence and Correlates of Symptom Persistence Following Acute Dengue Fever in Peru

Occurrence and Correlates of Symptom Persistence Following Acute Dengue Fever in Peru

Isolation and Characterization of Mayaro Virus from a Human in Acre, Brazil

Human Antibody Responses to Emerging Mayaro Virus and Cocirculating Alphavirus Infections Examined by Using Structural Proteins from Nine New and Old World Lineages

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