mBAND analysis for high- and low-LET radiation-induced chromosome aberrations: A review

Hada, Megumi; Wu, Honglu; Cucinotta, Francis A.

doi:10.1016/j.mrfmmm.2010.12.018

Cited by 39 publications

(17 citation statements)

References 76 publications

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“…Possible explanation for these finding is that the light bands contain more active genes than do the dark bands. Our findings also support other several studies that found that breakages induced by radiation were more frequent in light bands that are considered as gene-rich regions [21,22].…”

Section: Resultssupporting

confidence: 92%

Comparison of Radiosensitivity of Human Chromosomes 1, 2 and 4 from One Healthy Donor

2016

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Section: Resultssupporting

confidence: 92%

Comparison of Radiosensitivity of Human Chromosomes 1, 2 and 4 from One Healthy Donor

2016

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“…The CCRs are unstable since they decrease with the turnover of peripheral blood lymphocytes [57]. The presence of CCRs is considered to be a signature for high LET and heavy ion exposure [58,59]. There have been several reports that past irradiation can leave a permanent signature in the genome even several years after the exposure, as evident in plutonium workers exposed in 1949 in the Mayak Production Association near Ozyorsk, Russia [23], New Zealand nuclear test veterans exposed in 1957-1958 [60], patients treated with X-ray irradiation for ankylosing spondylitis [61], Hodgkin lymphoma patients treated with chemotherapy associated to radiation therapy [62], Hiroshima atomic bomb survivors [63,64], and Chernobyl cleanup workers [65][66][67].…”

Section: Complex Chromosomal Rearrangementsmentioning

confidence: 99%

Ionizing radiation biomarkers for potential use in epidemiological studies

Pernot

Hall

Baatout

et al. 2012

Mutation Research/Reviews in Mutation Research

201

153

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Ionizing radiation is a known human carcinogen that can induce a variety of biological effects depending on the physical nature, duration, doses and dose-rates of exposure. However, the magnitude of health risks at low doses and dose-rates (below 100mSv and/or 0.1mSvmin(-1)) remains controversial due to a lack of direct human evidence. It is anticipated that significant insights will emerge from the integration of epidemiological and biological research, made possible by molecular epidemiology studies incorporating biomarkers and bioassays. A number of these have been used to investigate exposure, effects and susceptibility to ionizing radiation, albeit often at higher doses and dose rates, with each reflecting time-limited cellular or physiological alterations. This review summarises the multidisciplinary work undertaken in the framework of the European project DoReMi (Low Dose Research towards Multidisciplinary Integration) to identify the most appropriate biomarkers for use in population studies. In addition to logistical and ethical considerations for conducting large-scale epidemiological studies, we discuss the relevance of their use for assessing the effects of low dose ionizing radiation exposure at the cellular and physiological level. We also propose a temporal classification of biomarkers that may be relevant for molecular epidemiology studies which need to take into account the time elapsed since exposure. Finally, the integration of biology with epidemiology requires careful planning and enhanced discussions between the epidemiology, biology and dosimetry communities in order to determine the most important questions to be addressed in light of pragmatic considerations including the appropriate population to be investigated (occupationally, environmentally or medically exposed), and study design. The consideration of the logistics of biological sample collection, processing and storing and the choice of biomarker or bioassay, as well as awareness of potential confounding factors, are also essential.

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“…Notably, recently developed fluorescence in situ hybridizationpainting methodologies have revealed that HZE particles induce a high fraction of complex type exchanges, and possibly unique chromosome rearrangements relative to c rays (120). Assessment of cytogenetic damage in blood lymphocytes of 16 astronauts before and after space missions (of 3 months or more) revealed that the frequency of chromosome exchanges measured within a month of return from space was higher than their preflight yield (99).…”

Section: Ros and Damage To Macromoleculesmentioning

confidence: 99%

Health Risks of Space Exploration: Targeted and Nontargeted Oxidative Injury by High-Charge and High-Energy Particles

Gonon

Buonanno

et al. 2014

Antioxidants & Redox Signaling

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mBAND analysis for high- and low-LET radiation-induced chromosome aberrations: A review

Cited by 39 publications

References 76 publications

Comparison of Radiosensitivity of Human Chromosomes 1, 2 and 4 from One Healthy Donor

Comparison of Radiosensitivity of Human Chromosomes 1, 2 and 4 from One Healthy Donor

Ionizing radiation biomarkers for potential use in epidemiological studies

Health Risks of Space Exploration: Targeted and Nontargeted Oxidative Injury by High-Charge and High-Energy Particles

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