MC1R Peptide Agonist Self-Assembles into a Hydrogel That Promotes Skin Pigmentation for Treating Vitiligo

Zhu, Ci; Li, Tingting; Wang, Zhuole; Li, Zenghui; Wei, Jiaying; Han, Ho Jae; Yuan, Dan; Cai, Minying; Shi, Junfeng

doi:10.1021/acsnano.3c01960

Cited by 18 publications

(5 citation statements)

References 52 publications

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“…However, after taVNS, the MDA concentration significantly decreased, and SOD and CAT activities were restored ( p < 0.05). Oxidative stress can induce apoptosis of melanocytes in the skin, resulting in reduced tyrosinase synthesis in apoptotic melanocytes [ 21 , 22 ]. We measured the level of tyrosinase in mouse skin, and the results showed a significant reduction in tyrosinase content in the skin of vitiligo mice.…”

Section: Resultsmentioning

confidence: 99%

Transcutaneous Auricular Vagus Nerve Stimulation Alleviates Monobenzone-Induced Vitiligo in Mice

Luo,

Meng,

et al. 2024

IJMS

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Vitiligo is a complex skin disorder that involves oxidative stress and inflammatory responses and currently lacks a definitive cure. Transcutaneous auricular vagus nerve stimulation (taVNS) is a noninvasive method for targeting the auricular branch of the vagus nerve and has gained widespread attention for potential intervention in the autonomic nervous system. Although previous research has suggested that vagus nerve stimulation can potentially inhibit inflammatory responses, its specific role and mechanisms in vitiligo treatment remain unknown. This study aimed to explore the therapeutic effects of taVNS in a mouse model of vitiligo induced by monobenzone. Initially, a quantitative assessment of the treatment effects on vitiligo mice was conducted using a scoring system, revealing that taVNS significantly alleviated symptoms, particularly by reducing the depigmented areas. Subsequent immunohistochemical analysis revealed the impact of taVNS treatment on melanocyte granules, mitigating pigment loss in the skin of monobenzone-induced vitiligo mice. Further analysis indicated that taVNS exerted its therapeutic effects through multiple mechanisms, including the regulation of oxidative stress, enhancement of antioxidant capacity, promotion of tyrosine synthesis, and suppression of inflammatory responses. The conclusions of this study not only emphasize the potential value of taVNS in vitiligo therapy, but also lay a foundation for future research into the mechanisms and clinical applications of taVNS.

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Section: Resultsmentioning

confidence: 99%

Transcutaneous Auricular Vagus Nerve Stimulation Alleviates Monobenzone-Induced Vitiligo in Mice

Luo,

Meng,

et al. 2024

IJMS

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“…Our experiments have shown that multiple cell lines can be cultured within the peptide hydrogel with high cell viability, enabling cells to grow into complex morphology. As a result, the peptide hydrogel developed shows great promise as a versatile tool for a variety of biomedical applications, including drug release, drug screening, and tissue engineering. ,− …”

Section: Discussionmentioning

confidence: 99%

A Dual-Responsive Peptide Hydrogel Protects Normal Cells from Anticancer Drug Treatments

Deng,

Xie,

Huang

et al. 2024

ACS Appl. Nano Mater.

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Enzyme-instructed self-assembly (EISA) represents a promising approach to generate functional biomaterials with unique properties for biomedical applications. While EISA has been extensively studied in the context of pericellular hydrogel formation for inhibiting cancer cells, its potential in protecting cells during antitumor drug treatment has remained unexplored. In this study, we designed a dualresponsive peptide 1p, which responds to both Ca 2+ and ALP, undergoing dephosphorylation on the cell surface. This process leads to the formation of a protective pericellular hydrogel that effectively shields cells from the harmful effects of anticancer drug cisplatin. Furthermore, our findings highlight the suitability of peptide hydrogel 1 for cell encapsulation and transplantation, thus broadening its potential applications in cell delivery. This study reports a peptide hydrogel capable of safeguarding normal cell during anticancer drug treatment and underscoring the great potential of the peptide hydrogel for diverse biomedical applications.

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“…Thus, MC1R emerges as a potential therapeutic target for vitiligo since MC1R plays a crucial role in regulating skin pigmentation. Recently, a novel MC1R peptide agonist is reported, and we will introduce it in the synthetic peptide modulators section [70].…”

Section: Melanomamentioning

confidence: 99%

“…Moreover, the peptide hydrogel shows potential for preventing UV-induced melanoma and other skin cancers. Consequently, Zhu et al suggest that this selective and potent MC1R agonist hydrogel presents an alternative for the treatment or prevention of skin pigmentation disorders such as EPP and melanoma [70].…”

Section: Peptide Agonist For Vitiligo Treatmentmentioning

confidence: 99%

Melanocortin 1 Receptor (MC1R): Pharmacological and Therapeutic Aspects

Mun

Kim

Shin

2023

IJMS

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Melanocortins play crucial roles in regulating the stress response, inflammation, and skin pigmentation. In this review, we focus on the melanocortin 1 receptor (MC1R), a G protein-coupled receptor primarily known for regulating skin pigmentation and exhibiting anti-inflammatory effects. First, we provide an overview of the structure, signaling pathways, and related diseases of MC1R. Next, we discuss the potential therapeutic use of synthetic peptides and small molecule modulators of MC1R, highlighting the development of various drugs that enhance stability through amino acid sequence modifications and small molecule drugs to overcome limitations associated with peptide characteristics. Notably, MC1R-targeted drugs have applications beyond skin pigmentation-related diseases, which predominantly affect MC1R in melanocytes. These drugs can also be useful in treating inflammatory diseases with MC1R expression present in various cells. Our review underscores the potential of MC1R-targeted drugs to treat a wide range of diseases and encourages further research in this area.

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MC1R Peptide Agonist Self-Assembles into a Hydrogel That Promotes Skin Pigmentation for Treating Vitiligo

Cited by 18 publications

References 52 publications

Transcutaneous Auricular Vagus Nerve Stimulation Alleviates Monobenzone-Induced Vitiligo in Mice

Transcutaneous Auricular Vagus Nerve Stimulation Alleviates Monobenzone-Induced Vitiligo in Mice

A Dual-Responsive Peptide Hydrogel Protects Normal Cells from Anticancer Drug Treatments

Melanocortin 1 Receptor (MC1R): Pharmacological and Therapeutic Aspects

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