McArdle Disease and Exercise Physiology

Kitaoka, Yu

doi:10.3390/biology3010157

Cited by 20 publications

(19 citation statements)

References 55 publications

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“…An outlier was also located within the gene coding for nebulette, a cardiac-specific actin-binding protein essential in the structure of the sarcomere Z-disc (Bonzo et al 2008). Another marker was within the gene coding for muscle glycogen phosphorylase (PYGM), the enzyme responsible for breaking up glycogen into glucose subunits to power muscle cells (Kitaoka 2014).…”

Section: Evidence For Local Adaptation In Migratory Traitsmentioning

confidence: 99%

Genomics and telemetry suggest a role for migration harshness in determining overwintering habitat choice, but not gene flow, in anadromous Arctic Char

Moore

Harris

Luyer

et al. 2017

Preprint

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Migration is a ubiquitous life history trait with profound evolutionary and ecological consequences. Recent developments in telemetry and genomics, when combined, can bring significant insights on the migratory ecology of non-model organisms in the wild.Here, we used this integrative approach to document dispersal, gene flow and potential for local adaptation in anadromous Arctic Char from six rivers in the Canadian Arctic.Acoustic telemetry data from 124 tracked individuals indicated asymmetric dispersal, with a large proportion of fish (72%) tagged in three different rivers migrating up the same short river in the fall. Population genomics data from 6,136 SNP markers revealed weak, albeit significant, population differentiation (average pairwise F ST = 0.011) and asymmetric dispersal was also revealed by population assignments. Approximate Bayesian Computation simulations suggested the presence of asymmetric gene flow, although in the opposite direction to that observed from the telemetry data, suggesting that dispersal does not necessarily lead to gene flow. These observations suggested that Arctic Char home to their natal river to spawn, but may overwinter in rivers with the shortest migratory route to minimize the costs of migration in non-breeding years.Genome scans and genetic-environment associations identified 90 outlier markers putatively under selection, 23 of which were in or near a gene. Of these, at least four were involved in muscle and cardiac function, consistent with the hypothesis that migratory harshness could drive local adaptation. Our study illustrates the power of integrating genomics and telemetry to study migrations in non-model organisms in logistically challenging environments such as the Arctic.

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Section: Evidence For Local Adaptation In Migratory Traitsmentioning

confidence: 99%

Genomics and telemetry suggest a role for migration harshness in determining overwintering habitat choice, but not gene flow, in anadromous Arctic Char

Moore

Harris

Luyer

et al. 2017

Preprint

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“…Jaringan vital tertentu, seperti jaringan pada otak dan jantung, tidak dapat bertahan lama tanpa suplai oksigen kontinu (Behringer, et al, 2014;Citirak, et al, 2016). Sebagian hasil oksidasi tersebut harus di buang dari sel-sel untuk mencegah penumpukan produk sampah asam, proses pembuangan ini dilakukan oleh ginjal, jika pembuangan sisa metabolisme tubuh ini tidak sempurna, maka akan menjadi racun dan menumpuk pada tubuh, sehingga menyebabkan kerusakan organ yang lain, contohnya adalah hepar (Kitaoka, 2014;Zaman, 2015;S.A.M, et al, 2013).…”

Section: Pembahasanunclassified

“…Pada pasien hemodialisis karena ginjal tidak dapat berfungsi dengan baik maka terjadilah penumpukan asam sisa metabolisme, yang dapat mengganggu fungsi otot yaitu asam laktat (Kitaoka, 2014;Zang, et al, 2015). Satu sampai dengan dua jam pertama proses hemodialisis, terjadi pemecahan sel darah dalam jumlah besar sehingga terjadi kondisi stres oksidatif untuk sementara pada setiap sel otot, yang dapat menyebabkan asam laktat meningkat dan terjadilah kram (Mori, et al, 2014).…”

Section: Pembahasanunclassified

Dampak Frekuensi Pernapasan Predialisis Terhadap Kram Otot Intradialisis Di Rsud Panembahan Senopati Bantul

Nekada

Judha

2019

Jurnal Keperawatan Indonesia

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Proses hemodialisis juga sering menimbulkan dampak kesakitan seperti terjadinya kram otot saat intradialisis. Tujuan penelitian ini untuk mengidentifikasi dampak meningkatnya frekuensi pernapasan terhadap kram otot intradialisis. Penelitian ini menggunakan metode kuantitatif dengan desain analitik cross sectional. Penelitian ini dilakukan di ruang hemodialisis RSUD Panembahan Senopati Bantul. Subyek penelitian ini diambil secara accidental sampling. Keseluruhan subyek penelitian ini adalah 91 responden. Peneliti mengukur frekuensi pernapasan predialisis dan mengkaji kram otot intradialisis. Penelitian ini menggunakan analisa bivariabel Chi-Square. Hasil analisa Chi-Square menunjukkan nilai p sebesar 0,020 yang berarti terdapat hubungan yang signifikan antara frekuensi napas predialisis terhadap kram otot intradialisis. Kram otot yang terjadi selama proses hemodialisis dapat terjadi karena adanya stress oksidatif selama intradialisis. Observasi frekuensi pernapasan dapat mengantisipasi adanya risiko stres oksidatif yang mungkin akan terjadi.

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“…Another marker was within the gene coding for muscle glycogen phosphorylase (PYGM), the enzyme responsible for breaking up glycogen into glucose subunits to power muscle cells (Kitaoka 2014). Finally, another marker was within the gene coding for fructose-1,6biphosphatase, which is involved in the conversion of glycerol into glucose (i.e., gluconeogenesis; Lamont et al 2006).…”

Section: Accepted Articlementioning

confidence: 99%

A method to address the non-random spatial distribution of on-board observer data to map landings and discards

et al. 2018

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Migration is a ubiquitous life history trait with profound evolutionary and ecological consequences. Recent developments in telemetry and genomics, when combined, can bring significant insights on the migratory ecology of non-model organisms in the wild. Here, we used this integrative approach to document dispersal, gene flow and potential for local adaptation in anadromous Arctic Char from six rivers in the Canadian Arctic. Acoustic telemetry data from 124 tracked individuals indicated asymmetric dispersal, with a large proportion of fish (72%) tagged in three different rivers migrating up the same short river in the fall. Population genomics data from 6,136 SNP markers revealed weak, albeit significant, population differentiation (average pairwise FST = 0.011) and asymmetric dispersal was also revealed by population assignments. Approximate Bayesian Computation simulations suggested the presence of asymmetric gene flow, although in the opposite direction to that observed from the telemetry data, suggesting that dispersal does not necessarily lead to gene flow. These observations suggested that Arctic Char home to their natal river to spawn, but may overwinter in rivers with the shortest migratory route to minimize the costs of migration in non-breeding years. Genome scans and genetic-environment associations identified 90 outlier markers putatively under selection, 23 of which were in or near a gene. Of these, at least four were involved in muscle and cardiac function, consistent with the hypothesis that migratory harshness could drive local adaptation. Our study illustrates the power of integrating genomics and telemetry to study migrations in non-model organisms in logistically challenging environments such as the Arctic.

show abstract

McArdle Disease and Exercise Physiology

Cited by 20 publications

References 55 publications

Genomics and telemetry suggest a role for migration harshness in determining overwintering habitat choice, but not gene flow, in anadromous Arctic Char

Genomics and telemetry suggest a role for migration harshness in determining overwintering habitat choice, but not gene flow, in anadromous Arctic Char

Dampak Frekuensi Pernapasan Predialisis Terhadap Kram Otot Intradialisis Di Rsud Panembahan Senopati Bantul

A method to address the non-random spatial distribution of on-board observer data to map landings and discards

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