McKittrick-Wheelock syndrome: rectal villous adenoma as a cause of acute renal failure

Díaz, Carlos Ordieres; Valle, Isabel Pérez; Varga, Molly; Martín, Pedro Amor; Posadilla, Marta Álvarez; Abascal, Ángel Cano; Fernández, Adrián Huergo

doi:10.17235/reed.2022.8518/2021

Cited by 2 publications

(2 citation statements)

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“…This last stage of decompensation is usually the cause of admission and investigation for hydroelectrolytic and metabolic imbalances, specifically acute kidney injury with hyponatremia and hypokalemia, if the tumor mass was not detected or addressed in previous evaluations. 1 2 3 4 5 6…”

Section: Discussionmentioning

confidence: 99%

McKittrick Wheelock Syndrome Secondary to Adenocarcinoma of the Rectum. Case Report and Diagnostic Considerations

Quintero,

Pacheco,

Sarmiento

2023

Journal of Coloproctology

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Introduction McKittrick-Wheelock syndrome is a rare entity characterized by chronic diarrhea, acute kidney injury, and hydroelectrolytic imbalance associated with a large rectal tumor, frequently a villous adenoma. Case report A 69-year-old male with chronic diarrhea with mucus. He underwent a colonoscopy with biopsies, reporting adenocarcinoma of the rectum in situ, and underwent a robot assisted intersphincteric resection with colo-anal anastomosis and a protecitive ileostomy. Discussion Described in 1954, this syndrome is manifested by electrolyte imbalance and acute renal injury secondary to diarrhea associated with a rectal villous adenoma, often with long lasting symptoms. The most frequent symptom being watery diarrhea with mucus. The definitive treatment consists of surgical resection. Conclusion Although this is a rare pathology, it should be considered as a differential diagnosis in cases of chronic diarrhea associated with water and electrolyte disorders.

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Section: Discussionmentioning

confidence: 99%

McKittrick Wheelock Syndrome Secondary to Adenocarcinoma of the Rectum. Case Report and Diagnostic Considerations

Quintero,

Pacheco,

Sarmiento

2023

Journal of Coloproctology

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“…29,31 Because it is an uncommon diagnosis, it is important to differentiate it from other conditions that have hydroelectrolytic disorders and secretory diarrhea in their presentation, since only when the syndrome is identified is the appropriate endoscopic or surgical treatment performed, thus being able to avoid its high lethality. 10,26,28…”

Section: 192428mentioning

confidence: 99%

McKittrick-Wheelock Syndrome: A Rare Cause of Potentially Fatal Chronic Diarrhea

Michelini¹,

Alvarez²

2023

JHS

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McKittrick-Wheelock syndrome is characterized by a state of extreme fluid and electrolyte depletion secondary to large colorectal tumors, often benign villous adenoma. It was first reported in 1954 by McKittrick and Wheelock. Patients present with chronic diarrhea, severe hyponatremia, hypokalemia, and/or acute kidney injury. This work consists of an elaborate bibliographic review, in order to elucidate what is known about this pathology classified as rare. It aims to improve the diagnosis and management of this potentially lethal syndrome and to understand its presentation and pathophysiology, in order to allow the physician to anticipate the patient's deterioration. Pathophysiologically, there is hypersecretion of prostaglandin E2 in secretory tubulovillous adenomas. However, it remains an uncommon and poorly recognized disease, presenting significant morbidity if not properly treated. Due to the long period between the onset of symptoms and diagnosis, therapy ends up being delayed. Definitive treatment, which often proves to be curative, must be performed after the patient has stabilized, by means of tumor resection. After fluid and electrolyte replacement and early definitive surgery, the prognosis tends to be good.

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McKittrick-Wheelock syndrome: rectal villous adenoma as a cause of acute renal failure

Cited by 2 publications

References 5 publications

McKittrick Wheelock Syndrome Secondary to Adenocarcinoma of the Rectum. Case Report and Diagnostic Considerations

McKittrick Wheelock Syndrome Secondary to Adenocarcinoma of the Rectum. Case Report and Diagnostic Considerations

McKittrick-Wheelock Syndrome: A Rare Cause of Potentially Fatal Chronic Diarrhea

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