2021
DOI: 10.1007/s00428-021-03232-0
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MCM3 is a novel proliferation marker associated with longer survival for patients with tubo-ovarian high-grade serous carcinoma

Abstract: Tubo-ovarian high-grade serous carcinomas (HGSC) are highly proliferative neoplasms that generally respond well to platinum/taxane chemotherapy. We recently identified minichromosome maintenance complex component 3 (MCM3), which is involved in the initiation of DNA replication and proliferation, as a favorable prognostic marker in HGSC. Our objective was to further validate whether MCM3 mRNA expression and possibly MCM3 protein levels are associated with survival in patients with HGSC. MCM3 mRNA expression was… Show more

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Cited by 13 publications
(10 citation statements)
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“…Separating prognostic information from predictive information requires controlled clinical trials and can often only be inferred from observational cohort studies. For example, the recently described favorable association of the proliferation marker MCM3 with survival is thought to be due to good response to standard platinum–taxane chemotherapy [ 66 ]. Another example is the prognostic association of BRCA1/2 mutations in patients, which could be at least partly due to a better response to platinum–taxane therapy [ 67 ].…”
Section: Molecular Subtypes Of Ovarian Carcinomasmentioning
confidence: 99%
“…Separating prognostic information from predictive information requires controlled clinical trials and can often only be inferred from observational cohort studies. For example, the recently described favorable association of the proliferation marker MCM3 with survival is thought to be due to good response to standard platinum–taxane chemotherapy [ 66 ]. Another example is the prognostic association of BRCA1/2 mutations in patients, which could be at least partly due to a better response to platinum–taxane therapy [ 67 ].…”
Section: Molecular Subtypes Of Ovarian Carcinomasmentioning
confidence: 99%
“…The six proteins form a heterohexameric complex with an 1:1:1:1:1:1 stoichiometry, which has DNA helicase activity (Das et al, 2014; Lee and Hurwitz, 2001; Miller et al, 2019; You et al, 1999). Independently, all these proteins have been reported to be upregulated in several cancers and associated with fast progression, proliferation, aggressiveness and short survival (Aporowicz et al, 2019; Cao et al, 2020; Das et al, 2014; Giaginis et al, 2009, 2011; Issac et al, 2019; Kang et al, 2022; Lee and Hurwitz, 2001; Stojkovic-Filipovic et al, 2016; Valverde et al, 2018; Wojnar et al, 2010; You et al, 1999). The relative abundances, extracted from MS data of the six elements of the MCM complex, were taken as a measurement of the proliferation rate of the cells in all samples included within the study.…”
Section: Resultsmentioning
confidence: 99%
“…Although the main function of CCNE1 is in cell‐cycle progression, the main oncogenic effect may be independent from proliferation. High proliferating HGSCs are associated with longer survival, likely because of better response to standard chemotherapy, 27,28 whereas CCNE1 alterations are associated with shorter survival and poor response to chemotherapy. CCNE1 protein expression is only weakly correlated with proliferation markers (Ki67, minichromosome maintenance complex component 3) 28 .…”
Section: Discussionmentioning
confidence: 99%
“…High proliferating HGSCs are associated with longer survival, likely because of better response to standard chemotherapy, 27,28 whereas CCNE1 alterations are associated with shorter survival and poor response to chemotherapy. CCNE1 protein expression is only weakly correlated with proliferation markers (Ki67, minichromosome maintenance complex component 3) 28 . Although uncontrolled cell‐cycle entry remains the main known function of CCNE1, overall, these data suggest that much of CCNE1's oncogenic function is related to a premature S‐phase entry resulting in chromosomal instability rather than increased proliferation 7,8 …”
Section: Discussionmentioning
confidence: 99%
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