2022
DOI: 10.3389/fonc.2022.1004324
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MCM4 is a novel prognostic biomarker and promotes cancer cell growth in glioma

Abstract: BackgroundGliomas account for 75% of all primary malignant brain tumors in adults and result in high mortality. Accumulated evidence has declared the minichromosome maintenance protein complex (MCM) gene family plays a critical role in modulating the cell cycle and DNA replication stress. However, the biological function and clinic characterization of nine MCM members in low-grade glioma are not yet clarified.MethodsIn this study, we utilized diverse public databases, including The Cancer Genome Atlas (TCGA), … Show more

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Cited by 11 publications
(10 citation statements)
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“…CCNB1 and MCM4 have previously been shown to play important roles in accelerating the cell cycle and promoting malignant tumor proliferation. 44,45 In bladder cancer, upregulated CRNKL1 expression has been identified as an important regulator of the cell cycle in bladder tumorigenesis, 46 while increased MCM4 expression has been observed and found to promote cell cycle progression and malignant proliferation. 47 However, an accelerated cell cycle is a critical factor that promotes tumor proliferation and progression.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…CCNB1 and MCM4 have previously been shown to play important roles in accelerating the cell cycle and promoting malignant tumor proliferation. 44,45 In bladder cancer, upregulated CRNKL1 expression has been identified as an important regulator of the cell cycle in bladder tumorigenesis, 46 while increased MCM4 expression has been observed and found to promote cell cycle progression and malignant proliferation. 47 However, an accelerated cell cycle is a critical factor that promotes tumor proliferation and progression.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, we observed a significant positive correlation between CRNKL1 expression and the expression of two genes ( CCNB1 and MCM4 ) involved in promoting the cell cycle. CCNB1 and MCM4 have previously been shown to play important roles in accelerating the cell cycle and promoting malignant tumor proliferation 44,45 . In bladder cancer, upregulated CRNKL1 expression has been identified as an important regulator of the cell cycle in bladder tumorigenesis, 46 while increased MCM4 expression has been observed and found to promote cell cycle progression and malignant proliferation 47 .…”
Section: Discussionmentioning
confidence: 99%
“…Minichromosome maintenance 8 (MCM8), a homologous recombination repair factor, plays a crucial role in regulating the initiation and extension of DNA replication [ 26 ]. MCM8 contributes to the progression of various cancers, such as cholangiocarcinoma, osteosarcoma, gastric cancer and glioma [ 48 51 ]. Abnormal upregulation of MCM8 expression is observed in glioma, and high expression of MCM8 is associated with poor prognosis [ 51 ].…”
Section: Discussionmentioning
confidence: 99%
“…While MCM8 has the standard domain structure, MCM9 contains an unusual C-terminal extension downstream of the AAA+ ATPase site 21 . In humans, defects associated with MCM8-9 were linked to primary ovarian failure and hence infertility 22 , 23 , and defects or overexpression of MCM8-9 may promote cancer 24 27 . Most reports to date suggest that MCM8-9 functions in meiosis and in DNA repair, particularly in homologous recombination (HR) in response to DNA interstrand crosslinks (ICLs), as well as to maintain replication fork stability 15 17 , 21 , 28 30 .…”
Section: Introductionmentioning
confidence: 99%